FlyBase Allele Report: Dmel\TER94[26-8]

General Information

Symbol

Dmel\TER94^26-8

Species

D. melanogaster

Name

FlyBase ID

FBal0104711

Feature type

allele

Associated gene

Dmel\TER94

Associated Insertion(s)

Carried in Construct

Also Known As

VCP^26-8

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Goldstein et al., 2001, Ruden et al., 2000)

diepoxybutane

(Goldstein et al., 2001)

gamma ray

(Goldstein et al., 2001)

Progenitor genotype

Cytology

Description

Amino acid replacement: E437A. This substitution is in the first ATPase motif.

(Ruden et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:9,991,849..9,991,849 [+]

Nucleotide change:

A9991849C

Amino acid change:

E437A | TER94-PA; E462A | TER94-PC; E395A | TER94-PD; E462A | TER94-PE

Reported amino acid change:

E450A

Comment:

TER94^26-8 is reported as a missense mutation that converts amino acid 450, glutamic acid, to alanine (IDAEV to IDAAV in the first ATPase motif. However this sequence of amino acids maps to 434 to 438 in the sequence (GB:AF202034) placing the mutation at amino acid 437.

(Ruden et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of frontotemporal dementia

CEA

(Rumpf et al., 2014)

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 6

CEA

(Rumpf et al., 2014)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates retinitis pigmentosa

modeled by ninaE^D1

(Griciuc et al., 2010)

modeled by ninaE^P37H

(Griciuc et al., 2010)

ameliorates neurodegenerative disease

modeled by Zzzz\CAG^{Q92.GMR.Tag:FLAG}

(Higashiyama et al., 2002)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

Contrary to expection, TER94^26-8 does not suppress polyQ-induced neurodegeneration by inhibiting polyQ aggregation.

(Higashiyama et al., 2002)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(2R)BSC158)

(Kahsai and Cook, 2018)

lethal (with Df(2R)X1)

(Goldstein et al., 2001)

Phenotype Manifest In

oocyte | germline clone

(Ruden et al., 2000)

Detailed Description

Statement

Reference

TER94^26-8/+ mutant adults do not exhibit significant defects in phototaxis at 20 days of light exposure (dle), nor any defects in geotaxis at 20 or 30 dle, and display normal photoreceptor depolarization following light stimulation, as compared to controls.

(Griciuc et al., 2010)

Germline clones arrest early in oogenesis.

(Ruden et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

TER94[+]/TER94^26-8 is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PF, atl^UAS.Tag:MYC

(O'Sullivan et al., 2013)

TER94[+]/TER94^26-8 is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PF, atl^UAS.Tag:MYC

(O'Sullivan et al., 2013)

TER94[+]/TER94^26-8 is a suppressor of abnormal neuroanatomy | adult stage phenotype of ninaE^D1

(Griciuc et al., 2010)

TER94[+]/TER94^26-8 is a suppressor of decreased cell number | adult stage phenotype of ninaE^D1

(Griciuc et al., 2010)

TER94[+]/TER94^26-8 is a suppressor of abnormal phototaxis | adult stage phenotype of ninaE^D1

(Griciuc et al., 2010)

TER94[+]/TER94^26-8 is a suppressor of abnormal neuroanatomy | adult stage | progressive phenotype of ninaE^P37H

(Griciuc et al., 2010)

TER94[+]/TER94^26-8 is a suppressor of decreased cell number | adult stage | progressive phenotype of ninaE^P37H

(Griciuc et al., 2010)

TER94[+]/TER94^26-8 is a suppressor of abnormal phototaxis | adult stage phenotype of ninaE^P37H

(Griciuc et al., 2010)

TER94[+]/TER94^26-8 is a suppressor of abnormal neurophysiology | adult stage phenotype of ninaE^P37H

(Griciuc et al., 2010)

TER94[+]/TER94^26-8 is a suppressor | partially of visible phenotype of Zzzz\CAG^{Q92.GMR.Tag:FLAG}

(Higashiyama et al., 2002)

NOT Suppressor of

Statement

Reference

TER94[+]/TER94^26-8 is a non-suppressor of visible phenotype of Cele\ced-4^GMR.PK

(Higashiyama et al., 2002)

TER94[+]/TER94^26-8 is a non-suppressor of visible phenotype of Hsap\TP53^UAS.cYa

(Higashiyama et al., 2002)

TER94[+]/TER94^26-8 is a non-suppressor of visible phenotype of hid^GMR.PG

(Higashiyama et al., 2002)

TER94[+]/TER94^26-8 is a non-suppressor of visible phenotype of grim^GMR.PC

(Higashiyama et al., 2002)

TER94[+]/TER94^26-8 is a non-suppressor of visible phenotype of rpr^GMR.PW

(Higashiyama et al., 2002)

Phenotype Manifest In

Suppressor of

Statement

Reference

TER94[+]/TER94^26-8 is a suppressor | partially of eye phenotype of Scer\GAL4^ey.PH, atl^UAS.Tag:MYC

(O'Sullivan et al., 2013)

TER94[+]/TER94^26-8 is a suppressor of retina | adult stage phenotype of ninaE^D1

(Griciuc et al., 2010)

TER94[+]/TER94^26-8 is a suppressor of eye photoreceptor cell | adult stage phenotype of ninaE^D1

(Griciuc et al., 2010)

TER94[+]/TER94^26-8 is a suppressor of retina | adult stage | progressive phenotype of ninaE^P37H

(Griciuc et al., 2010)

TER94[+]/TER94^26-8 is a suppressor of eye photoreceptor cell | adult stage | progressive phenotype of ninaE^P37H

(Griciuc et al., 2010)

TER94[+]/TER94^26-8 is a suppressor | partially of eye phenotype of Zzzz\CAG^{Q92.GMR.Tag:FLAG}

(Higashiyama et al., 2002)

NOT Suppressor of

Statement

Reference

TER94[+]/TER94^26-8 is a non-suppressor of eye phenotype of Cele\ced-4^GMR.PK

(Higashiyama et al., 2002)

TER94[+]/TER94^26-8 is a non-suppressor of eye phenotype of Hsap\TP53^UAS.cYa

(Higashiyama et al., 2002)

TER94[+]/TER94^26-8 is a non-suppressor of eye phenotype of hid^GMR.PG

(Higashiyama et al., 2002)

TER94[+]/TER94^26-8 is a non-suppressor of eye phenotype of grim^GMR.PC

(Higashiyama et al., 2002)

TER94[+]/TER94^26-8 is a non-suppressor of eye phenotype of rpr^GMR.PW

(Higashiyama et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The small eye phenotype characteristic for adult flies expressing atl^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PF is significantly ameliorated by combination with a single copy of TER94^26-8.

(O'Sullivan et al., 2013)

TER94^26-8/+ partially suppresses the retinal degeneration and photoreceptor neuron loss after 30 days, but not after 20 days, of light exposure; rescues the visual processing defects after 20 days of light exposure; and rescues the photoreceptor depolarization defect seen in flies expressing ninaE^P37H.

TER94^26-8/+ partially suppresses the retinal degeneration, loss of photoreceptor neurons and fully suppresses the defective phototaxis seen in ninaE^D1/+ mutant flies.

Expression of ninaE^+t2.747 in a TER94^26-8/+ background does not result in defects in phototaxis or geotaxis after 20 or 30 days of light exposure, and does not result in a defect in photoreceptor depolarization after 30 or 45 days of light exposure, as compared to controls.

(Griciuc et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9872

Adh^fn23 pr¹ cn¹ TER94^26-8/CyO

Notes on Origin

Discoverer

Comments

Phenotypic analysis suggests an allelic series, starting from the strongest: TER94^k15502, TER94^26-8, TER94⁰³⁷⁷⁵, TER94^22-30, TER94^14-23, TER94^22-26, TER94^7-12 and TER94^43-8.

(Ruden et al., 2000)

"ethyl methanesulfonate" was stated as tentative. "diepoxybutane" was stated as tentative. "γ ray" was stated as tentative.

(Goldstein et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

26-8

(Goldstein et al., 2001)

TER94^26-28

(O'Sullivan et al., 2013)

TER94^26-8

(Kahsai and Cook, 2018)

VCP^26-28

(O'Sullivan et al., 2013)

VCP^26-8

(Griciuc et al., 2010)

dvcp^26-8

(Rumpf et al., 2011)

ter94^26-8

(Higashiyama et al., 2002, Ruden et al., 2000)

vcp^26-8

(Rumpf et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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