FB2024_03 , released June 25, 2024
Allele: Dmel\atlUAS.Tag:MYC
Open Close
General Information
Symbol
Dmel\atlUAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0244004
Feature type
allele
Associated gene
Dmel\atl
Associated Insertion(s)
Carried in Construct
P{UAS-atl.myc}
Key Links
Transgenic product class
wild_type
(Orso et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Orso et al., 2009)
Mutagen
in vitro construct
(Orso et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-atl.myc}
Cytology
Description

UASt regulatory sequences drive expression of a Tag:MYC-tagged atl.

(Orso et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
atl
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of atlScer\UAS.T:Hsap\MYC driven by Scer\GAL4arm.PS does not affect mEJP amplitude at the NMJ of third instar larvae.

      Overexpression of atlScer\UAS.T:Hsap\MYC driven by Scer\GAL4Toll-6-D42 causes accumulation of large endoplasmic reticulum punctae in motor neuron cell bodies and axons in third instar larvae; excitatory junction potential (EJP) amplitude is significantly decreased (at 0.1 mM Ca[2+], accompanied by a significant decrease in frequency of synaptic transmission successes); corrected quantal content at 1.5 mM Ca[2+] significantly decreases compared to controls at the neuromuscular junction of third instar larvae.

      (Summerville et al., 2016)

      Expression of atlScer\UAS.T:Hsap\MYC under the control of Scer\GAL4ey.PH or Scer\GAL4GMR.PF results in a rough eye or a small eye phenotype, respectively.

      (O'Sullivan et al., 2013)

      Ultrastructural analysis shows considerable disruption of endoplasmic reticulum (ER) networks in neurons as a result of atlScer\UAS.T:Hsap\MYC] overexpression driven by Scer\GAL4D42. Normal tubular ER profiles are absent in atlScer\UAS.T:Hsap\MYC] overexpressing motoneurons where ER membranes form expanded cisternae.

      (Orso et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Suppressed by
      Phenotype Manifest In
      Enhanced by
      Suppressed by
      Statement
      Reference

      Scer\GAL4ey.PH, atlUAS.Tag:MYC has eye phenotype, suppressible | partially by TER94[+]/TER94k15502

      (O'Sullivan et al., 2013)

      Scer\GAL4ey.PH, atlUAS.Tag:MYC has eye phenotype, suppressible | partially by TER94[+]/TER9426-8

      (O'Sullivan et al., 2013)

      Scer\GAL4ey.PH, atlUAS.Tag:MYC has eye phenotype, suppressible | partially by TER9403775/TER94[+]

      (O'Sullivan et al., 2013)

      Scer\GAL4ey.PH, atlUAS.Tag:MYC has eye phenotype, suppressible | partially by TER94[+]/TER9422-30

      (O'Sullivan et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The small eye phenotype characteristic for adult flies expressing atlScer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PF is exacerbated further by co-expression of TER94Scer\UAS.cRa and is significantly ameliorated by combination with a single copy of any of the following alleles: TER9403775, TER9422-30, TER94k15502 or TER9426-8. The rough eye phenotype of flies expressing atlScer\UAS.T:Hsap\MYC driven by Scer\GAL4ey.PH is also worsened by TER94Scer\UAS.cRa co-expression leading to rough eyes of reduced size.

      (O'Sullivan et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4arm.PS/atlUAS.Tag:MYC rescues atl2

      (Summerville et al., 2016)
      Comments

      Expression of atlScer\UAS.T:Hsap\MYC driven by Scer\GAL4arm.PS significantly rescues decreased EJP amplitude at the NMJ of atl2/atl2 third instar larvae.

      (Summerville et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      atlScer\UAS.T:Hsap\MYC
      atlScer\UAS.T:Hsap\MYC</up>
      atlUAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (5)