FlyBase Allele Report: Dmel\TER94[03775]

General Information

Symbol

Dmel\TER94⁰³⁷⁷⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0008040

Feature type

allele

Associated gene

Dmel\TER94

Associated Insertion(s)

P{PZ}TER94⁰³⁷⁷⁵

Carried in Construct

Also Known As

l(2)03775

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}TER94⁰³⁷⁷⁵

Cytology

Description

Insertion in the 5' non-coding region.

(Higashiyama et al., 2002)

Insertion in the 5' UTR of TER94. Site of insertion in TER94^k15502 and TER94⁰³⁷⁷⁵ are identical.

(Ruden et al., 2000)

P{PZ} insertion in the 5' untranslated region.

(Leon and McKearin, 1999)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:9,989,185..9,989,185 [-]

(Higashiyama et al., 2002, Beaton, 2000.1.31, Leon and McKearin, 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates amyotrophic lateral sclerosis

modeled by caz^VDRC.cUa

(Azuma et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

egg chamber | germline clone

(Ruden et al., 2000)

endoplasmic reticulum & egg chamber

(Ruden et al., 2000)

germarium | germline clone

(Ruden et al., 2000)

Detailed Description

Statement

Reference

Female germ-line clones do not produce germaria or egg chambers. TER94⁰³⁷⁷⁵ mutant egg chambers have abnormal endoplasmic reticulum. DiO-C₆ staining is weaker and more particulate than seen in wildtype. The fusome is wild-type in these embryos.

(Ruden et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

TER94⁰³⁷⁷⁵/TER94[+] is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^GMR.PS, caz^VDRC.cUa

(Azuma et al., 2014)

Suppressor of

Statement

Reference

TER94⁰³⁷⁷⁵/TER94[+] is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PF, atl^UAS.Tag:MYC

(O'Sullivan et al., 2013)

TER94⁰³⁷⁷⁵/TER94[+] is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PF, atl^UAS.Tag:MYC

(O'Sullivan et al., 2013)

TER94⁰³⁷⁷⁵/TER94[+] is a suppressor | partially of visible phenotype of Zzzz\CAG^{Q92.GMR.Tag:FLAG}

(Higashiyama et al., 2002)

Phenotype Manifest In

Enhancer of

Statement

Reference

TER94⁰³⁷⁷⁵/TER94[+] is an enhancer of eye phenotype of Scer\GAL4^GMR.PS, caz^VDRC.cUa

(Azuma et al., 2014)

TER94⁰³⁷⁷⁵/TER94[+] is an enhancer of ommatidium phenotype of Scer\GAL4^GMR.PS, caz^VDRC.cUa

(Azuma et al., 2014)

TER94⁰³⁷⁷⁵/TER94[+] is an enhancer of interommatidial bristle phenotype of Scer\GAL4^GMR.PS, caz^VDRC.cUa

(Azuma et al., 2014)

Suppressor of

Statement

Reference

TER94⁰³⁷⁷⁵/TER94[+] is a suppressor | partially of eye phenotype of Scer\GAL4^ey.PH, atl^UAS.Tag:MYC

(O'Sullivan et al., 2013)

TER94⁰³⁷⁷⁵/TER94[+] is a suppressor | partially of eye phenotype of Zzzz\CAG^{Q92.GMR.Tag:FLAG}

(Higashiyama et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygous TER94⁰³⁷⁷⁵ enhances the rough-eye phenotype induced by Scer\GAL4^GMR.PS>caz^VDRC.cUa.

(Azuma et al., 2014)

The small eye phenotype characteristic for adult flies expressing atl^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PF is significantly ameliorated by combination with a single copy of TER94⁰³⁷⁷⁵.

(O'Sullivan et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

TER94^k15502

(Leon and McKearin, 1999)

TER94^k15502

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11349

cn¹ P{PZ}TER94⁰³⁷⁷⁵/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

Comments

Phenotypic analysis suggests an allelic series, starting from the strongest: TER94^k15502, TER94^26-8, TER94⁰³⁷⁷⁵, TER94^22-30, TER94^14-23, TER94^22-26, TER94^7-12 and TER94^43-8.

(Ruden et al., 2000)

After six generations of outcrossing the lethality continued to segragate with the P{PZ} insertion.

(Beaton, 2000.1.31)

Complements: 14-3-3ζ⁰⁷¹⁰³. Complements: l(2)k08601^k08601. Complements: Adam^k13906.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

TER94⁰³⁷⁷⁵

(Kahsai and Cook, 2018, O'Sullivan et al., 2013)

VCP⁰³⁷⁷⁵

(O'Sullivan et al., 2013)

l(2)03775

(Higashiyama et al., 2002, Goldstein et al., 2001, Leon and McKearin, 1999, Spradling et al., 1999)

l(2)03775⁰³⁷⁷⁵

(Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)

ter94⁰³⁷⁷⁵

(Azuma et al., 2014, Ruden et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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