FlyBase Aberration Report: Dmel\Df(2R)M41A4

General Information

Symbol

Df(2R)M41A4

Species

D. melanogaster

Name

Deficiency (2R) Minute 41A

FlyBase ID

FBab0001993

Feature type

chromosomal_deletion

Also Known As

Df(2R)M-S2⁴, Df(2R)MS2⁴, M41 A4

Computed Breakpoints include

h44-h46;42A1-42A2

Features within h44--42A2

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

X ray

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Duffy et al., 1996, Koryakov and Zhimulev, 1996, Koryakov et al., 1996, Pauli et al., 1995, Dimitri, 1991)

Breakpoints

[];h46

(Dimitri, 1991)

41A;41A

(Duffy et al., 1996, Pauli et al., 1995)

41A;[]

(Harbecke and Lengyel, 1995)

41C;42A1-42A2

(Koryakov and Zhimulev, 1996)

[];42A1--2

(Koryakov et al., 1996)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

uex << bk1 << RpL38 << ap << bk2 << mle

Genetic mapping information

Comments

This deletion removes a single ribosomal protein-coding gene (though other genes are also removed).

(Marygold et al., 2007)

Comments on Cytology

Euchromatic breakpoint not reported.

(Dimitri, 1991)

Left limit of break 1 from non-inclusion of uex (FBrf0028786) Right limit of break 1 from inclusion of l(2)41Ae (FBrf0027524) Limits of break 2 from polytene analysis (FBrf0091444)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

(Koryakov and Zhimulev, 1996, Eberl et al., 1993, Dimitri, 1991, Cicchetti and Loverre, 1988, Sharp et al., 1985, Ganetzky, 1977, Hilliker and Holm, 1975)

IntS3

(Marygold et al., 2005)

l(2)41Ae

(Duffy et al., 1996, Koryakov and Zhimulev, 1996, Eberl et al., 1993, Sharp et al., 1985, Ganetzky, 1977, Hilliker, 1976, Hilliker and Holm, 1975)

l(2)NC204

(Marygold et al., 2005)

Nipped-A

(Duffy et al., 1996, Koryakov and Zhimulev, 1996, Eberl et al., 1993, Ganetzky, 1977, Hilliker, 1976)

Nipped-B

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

p120ctn

(Myster et al., 2004)

RpL38

(Marygold et al., 2005, Duffy et al., 1996, Eberl et al., 1993, Cicchetti and Loverre, 1988, Ganetzky, 1977, Hilliker, 1976, Hilliker and Holm, 1975)

stw

(Koryakov and Zhimulev, 1996, Eberl et al., 1993, Dimitri, 1991, Cicchetti and Loverre, 1988, Ganetzky, 1977, Hilliker and Holm, 1975)

sxc

(Sinclair et al., 2009)

uex

(Marygold et al., 2005, Hilliker and Holm, 1975)

vlc

(Gates and Thummel, 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Partially deleted / disrupted

Molecular Data

Completely deleted

RpL38

(Marygold et al., 2007)

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

(Cicchetti and Loverre, 1988)

BubR1

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

(Cicchetti and Loverre, 1988)

crc

(Hilliker and Holm, 1975)

EcR

(BDGP Project Members, 1994-1999)

l(2)40Fa

(Hilliker and Holm, 1975)

l(2)40Fg

(Hilliker and Holm, 1975)

l(2)41Ab

(Eberl et al., 1993, Ganetzky, 1977, Hilliker, 1976)

l(2)42Aa

(Roote and Ashburner, 2005.6)

l(2)42Ab

(Roote and Ashburner, 2005.6)

l(2)42Ac

(Roote and Ashburner, 2005.6)

l(2)05315

(BDGP Project Members, 1994-1999)

l(2)09851

(Spradling et al., 1999)

l(2)Co

(Cicchetti and Loverre, 1988)

l(2)gl

(Mason et al., 2004)

l(2)k03002a

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

l(2)k07312b

(BDGP Project Members, 1994-1999)

(Cicchetti and Loverre, 1988, Hilliker and Holm, 1975)

mle

(Cicchetti and Loverre, 1988)

Pal1

(Bien-Willner et al., 1997)

(Cicchetti and Loverre, 1988)

ptc

(Sturtevant, 1948)

(Eberl et al., 1993, Ganetzky, 1977, Hilliker, 1976, Hilliker and Holm, 1975)

Rsp

(Eberl et al., 1993)

S(CycE^JP)2.10

(Brumby et al., 2004)

Src42A

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

(Cicchetti and Loverre, 1988)

tri

(Hilliker and Holm, 1975)

uex

(Eberl et al., 1993, Sharp et al., 1985, Ganetzky, 1977, Hilliker, 1976)

Yeti

(Eberl et al., 1993, Ganetzky, 1977, Hilliker, 1976)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location

Related Comments

Phenotypic Data

In combination with other aberrations

The z¹ In(1)w^is eye colour phenotype is enhanced by Df(2R)M41A4.

(Rasmuson-Lestander et al., 1993)

Lethal in combination with Df(2R)M41A10.

(Hilliker and Holm, 1975, Curry, 1939)

NOT in combination with other aberrations

Flies heterozygous for the deletion show a Minute bristle phenotype.

(Marygold et al., 2007)

Has no effect on viability of Asx¹² or Asx¹⁴, and homeotic transformations in double mutants are mild. Anterior transformations of A5 to A4 do occur, similar to those seen in trx-G group mutants.

(Milne et al., 1999)

Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

(Coyne et al., 1998)

Weak second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1 : malformed phenotype penetrance 10-24%.

(Halsell and Kiehart, 1998)

Shows no maternal enhancement of dpp^hr4.

(Nicholls and Gelbart, 1998)

Acts as a dosage sensitive maternal modifier of run : causes tergite defects in greater than 64% of run³ heterozygotes.

(Duffy et al., 1996)

Midgut development of mutant embryos is wild type.

(Bilder and Scott, 1995)

Homozygous embryos are very abnormal compared to wild-type. Formation of the gut is variable.

(Harbecke and Lengyel, 1995)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Heterozygotes show a Minute phenotype. Homozygous lethal.

(Hilliker and Holm, 1975)

homozygous lethal Medium Minute bristles. Large pale body with heavy, malformed, bloated abdomen. Female fertility low.

Stocks (3)

739

108912

103281

Df(2R)M41A4 / SM1, al² Duox^Cy cn² speck²

Notes on Origin

Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

The Df(2R)M41A4 chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is assumed to be a false positive result (the suppressor may not be within the bounds of the deficient region) because the 2L TAS array on the chromosome is reduced (as assayed by in situ hybridization) and it has previously been shown (FBrf0137248, FBrf0158986) that partial or complete deficiency of the 2L TAS array on the homologue suppresses silencing of brown-red variants of P{3'WP-2,w^var}2Lt.

(Mason et al., 2004)

Synonyms and Secondary IDs (21)

Reported As

Symbol Synonym

41A4

(Dimitri et al., 2005)

Df(2)M-S4

(Curry, 1939)

Df(2R)M-S2-4

(Harbecke and Lengyel, 1995)

Df(2R)M-S2⁴

(Collett, 2008.2.16, Abrell et al., 2000, Duffy et al., 1996, Ganetzky, 1977, Hilliker, 1976)

Df(2R)M-S4

(Sharp et al., 1985)

Df(2R)M41

(Coyne et al., 1998)

Df(2R)M41A4

(Tan et al., 2020, Clough et al., 2014, Galindo et al., 2014, Sinclair et al., 2009)

Df(2R)MS2-4

(Cicchetti and Loverre, 1988)

Df(2R)MS24

(Koryakov and Zhimulev, 1996)

Df(2R)MS2⁴

(Milne et al., 1999, Koryakov and Zhimulev, 1996, Koryakov et al., 1996, Eberl et al., 1993)

Df(2R)m41A4

(Gildea et al., 2000)

DfMS4

(Sturtevant, 1948)

M(2)S-4

(Hilliker, 1976)

M(2)S2⁴

M(2)S4

(Ganetzky, 1977)

M(2R)S24

(Rasmuson-Lestander et al., 1993)

M-S2⁴

(Dimitri, 1991)

M41 A4

(Yamaguchi et al., 2001, Yamaguchi et al., 1999)

M41A4

(Hirose et al., 2001)

MS2-4

(Hilliker and Holm, 1975)

Name Synonyms

Deficiency (2R) Minute 41A

Secondary FlyBase IDs

References (61)

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