FB2024_02 , released April 23, 2024
Gene: Dmel\Rsp
Open Close
General Information
Symbol
Dmel\Rsp
Species
D. melanogaster
Name
Responder to Sd
Annotation Symbol
Feature Type
repeat_region
FlyBase ID
FBgn0003284
Gene Model Status
Unannotated
Stock Availability
12 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Responder

Function
Gene Ontology (GO) Annotations (0 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Phenotypic Description (Red Book; Lindsley and Zimm 1992)
    Rsp: Responder
    The region of the chromosome upon which Sd acts to cause dysfunction of sperm that receive it; the sensitivity of Rsp is unaffected by its position in the genome, being equally responsive to Sd either in repulsion or coupling with Sd, or when located ectopically as in Dp(2;f)Rsp (Brittnacher and Ganetzky, 1989, Genetics 121: 739-50) or in Dp(2;Y)Rsp (Lyttle and Ault, 1985, Genetics 110: s23; Lyttle, 1989, Genetics 121: 751-63).
    Gene Model and Products
    Number of Transcripts
    0
    Number of Unique Polypeptides
    0
    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Structure
    Experimentally Determined Structures
    Crossreferences
    Comments on Gene Model
    Sequence Ontology: Class of Gene
    repeat_region
    Transcript Data
    Annotated Transcripts
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Polypeptides with Identical Sequences

     

    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Nucleotide / Polypeptide Records
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rsp using the Feature Mapper tool.

    External Data
    Crossreferences
    Linkouts
    Expression Data
    Testis-specificity index

    The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

    NA

    Transcript Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    JBrowse - Visual display of RNA-Seq signals

    View Dmel\Rsp in JBrowse
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Bulk Downloads
    RNA-Seq RPKM values for all genes
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Alleles, Insertions, Transgenic Constructs, and Aberrations
    Classical and Insertion Alleles ( 16 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 0 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of Rsp
    Transgenic constructs containing regulatory region of Rsp
    Aberrations (Deficiencies and Duplications) ( 22 )
    Variants
    Variant Molecular Consequences
    Alleles Representing Disease-Implicated Variants
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Lethality
    Allele
    viable
    Sterility
    Allele
    fertile
    Phenotype manifest in
    Allele
    Orthologs
    Downloads
    Download All DIOPT Orthologs
    Human Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    Domainoid
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Complementation?
    Transgene?
    Homo sapiens (Human) (0)
    Model Organism Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    Domainoid
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Complementation?
    Transgene?
    Rattus norvegicus (Norway rat) (0)
    Mus musculus (laboratory mouse) (0)
    Xenopus tropicalis (Western clawed frog) (0)
    Danio rerio (Zebrafish) (0)
    Caenorhabditis elegans (Nematode, roundworm) (0)
    Anopheles gambiae (African malaria mosquito) (0)
    Arabidopsis thaliana (thale-cress) (0)
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    Schizosaccharomyces pombe (Fission yeast) (0)
    Escherichia coli (enterobacterium) (0)
    Other Organism Orthologs (via OrthoDB)
    Data provided directly from OrthoDB:Rsp. Refer to their site for version information.
    Paralogs
    Downloads
    Download All DIOPT Paralogs
    Paralogs (via DIOPT v9.1)
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Other Interaction Browsers
      Summary of Genetic Interactions
      esyN Network Diagram
      Other Interaction Browsers
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      Recombination map
      2-56.61
      Cytogenetic map
      h38-h38
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      h38-h38
      Left limit from inclusion within Tp(2;Y)cb25-24 (FBrf0049925) Right limit from inclusion within Tp(2;Y)cb25-24 (FBrf0049925)
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      h39-h39
      (Marsano, 2002.9.16)
      Experimentally Determined Recombination Data
      Location

      2-56.61

      Left of (cM)
      (Sharp et al., 1985)
      (Ganetzky, 1977)
      Right of (cM)
      (Sharp et al., 1985)
      Notes

      Mapping based on 122 pr-cn recombinants.

      Stocks and Reagents
      Stocks (12)
      Genomic Clones (0)
       
        cDNA Clones (0)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
                Other clones
                  RNAi and Array Information
                  Linkouts
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Cell Line Information
                  Publicly Available Cell Lines
                   
                    Other Stable Cell Lines
                     
                      Other Comments

                      All naturally occurring SD chromosomes carry RanGapSD and Rspi. Typical SD+ chromosomes carry Rsps and its presence is sufficient to render a chromosome sensitive to the action of RanGapSD. Some SD+ chromosomes carry Rspi. To cause high levels of distortion, RanGapSD requires the presence of a series of upward modifiers known as E(SD)unspecified, St-SDunspecified and M(Sd)unspecified.

                      (Kusano et al., 2003)

                      Analysis of the large scale molecular structure of Rsp reveals that Rsp repeats isolated from one chromosome are not more similar than those from a different chromosome, the repeats usually have a dimeric structure and frequent unequal crossover events can obscure the phylogenetic relationships between repeats.

                      (Cabot et al., 1993)

                      The recessive semi-lethality caused by Df(2R)Rsp16, and previously suggested to be due to the deletion of Rsp, may actually be at least partly due to the deletion of closely linked Bari1.

                      (Caizzi et al., 1993)

                      Structural role of Rsp is determined by preferentially perturbing the locus using Hoechest 33258.

                      (Doshi et al., 1991)

                      Rsp is the target for the action of RanGapSD and can exist in a sensitive or insensitive state. E(SD)unspecified distortion is mediated via Rsp, whether Rsp is on the Y or second chromosome. E(SD)unspecified is independently capable of acting on Rsp and is not a simple modifier of RanGapSD.

                      (Temin, 1991)

                      A possible relationship between the SD system of segregation distortion and the P, I and hobo transposable element systems has been suggested.

                      (Golic, 1990)

                      Rsp is the most proximal known locus within the 2R heterochromatin: determined by free duplications for the centromeric region of the second chromosome and their sensitivity to distortion.

                      (Brittnacher and Ganetzky, 1989)

                      Rsp has been mapped as the most proximal locus in 2R heterochromatin by cytology and lethal complementation tests of autosomal insertions into the long arm of the Y chromosome. This suggests that Rsp is separable from the second chromosome centromere and its behaviour does not depend on gross chromosomal position.

                      (Lyttle, 1989)

                      The sensitivity of Rsp to RanGapSD depends on the size of the h39 band: this demonstrates that the Rsp locus is composed of repeated DNA.

                      (Pimpinelli and Dimitri, 1989)

                      In flies without SD, deletion of the Rsp region results in flies (both male and female) that are less fit than Rsp+ flies.

                      (Wu et al., 1989)

                      Dp(2;Y)Sd causes dysfunction of Rsps bearing sperm indicating that Rsp activity does not depend on pairing with a normal autosomal homologue.

                      (Lyttle, 1986)

                      Spontaneous and radiation-induced recombination analyses and deficiency studies of the SD-5 chromosome provide evidence that the Rsp locus lies within the proximal heterochromatin of the right arm of chromosome 2.

                      (Sharp et al., 1985)

                      To investigate how SD behaves and is maintained in nature the major components of the SD system have been examined in two natural populations.

                      (Temin and Marthas, 1984)
                      Relationship to Other Genes
                      Source for database merge of
                      Additional comments
                      Nomenclature History
                      Source for database identify of
                      Nomenclature comments
                      Etymology
                      Synonyms and Secondary IDs (11)
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      Study result (0)
                      Result
                      Result Type
                      Title
                      External Crossreferences and Linkouts ( 9 )
                      Sequence Crossreferences
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      Linkouts
                      DroID - A comprehensive database of gene and protein interactions.
                      References (104)