FlyBase Aberration Report: Dmel\Df(4)M101-62f

General Information

Symbol

Df(4)M101-62f

Species

D. melanogaster

Name

Deficiency (4) Minute

FlyBase ID

FBab0002960

Feature type

chromosomal_deletion

Also Known As

Df(4)M62f, Df(4)M^62f, M^62f

Computed Breakpoints include

[<101F1];102B

Features within 101F1--102B

Genomic Maps

JBrowse

Sequence coordinates

4:1..43,778 (Df(4)M101-62f:bk1)

(Cook, 2016.2.8)

4:69,326..441,648 (Df(4)M101-62f:bk2)

(Cook, 2016.2.8)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

gamma ray

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Dooijes et al., 1998, Locke and Hanna, 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Eaton and Kornberg, 1990)

Breakpoints

101E-101F;102B2-102B5

(Eaton and Kornberg, 1990)

101E;102B

(Dooijes et al., 1998, Ayme-Southgate et al., 1995)

101E;102B10-102B17

(Locke and Hanna, 1996, Pauli et al., 1995)

101E;102D13-102E1

(Harbecke and Lengyel, 1995)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

bk1 << ci << pan << bk2 << bt

Genetic mapping information

Comments

The 4:1..43778 release 6 coordinates of the left breakpoint are estimates. The left extent corresponds to the left end of the chromosome 4 genome assembly, because the breakpoint may reside in 4th chromosome centric heterochromatin. The right extent corresponds to the right end of PlexB, which published results say is deleted.

(Cook, 2016.2.8)

The 4:69326..441648 release 6 coordinates of the right breakpoint are estimates. The left extent corresponds to the left end of pan, which published results say is deleted. The right extent corresponds to the estimated position of the right end of polytene band 102B8, because published cytologies indicate the breakpoint lies in subdivision 102B.

(Cook, 2016.2.8)

Comments on Cytology

Restriction mapping suggests that the Df(4)M101-62f chromosome is rearranged rather than deleted.

(Ayme-Southgate et al., 1995)

Right limit of break 1 from inclusion of ci (FBrf0073755) Limits of break 2 from polytene analysis (FBrf0079869)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

(Kronhamn and Rasmuson-Lestander, 1999, Cavallo et al., 1998, Dominguez et al., 1996, Harbecke and Lengyel, 1995, Johnson et al., 1995, Slusarski et al., 1995, Locke and Tartof, 1994)

pan

(Kronhamn and Rasmuson-Lestander, 1999, Cavallo et al., 1998, Dooijes et al., 1998, Brunner et al., 1997, van de Wetering et al., 1997)

PlexB

(Ayoob et al., 2006)

RpS3A

(Kronhamn and Rasmuson-Lestander, 1999)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

(Ayme-Southgate et al., 1995)

l(4)B6-C1

(Sousa-Neves et al., 2005)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location

Related Comments

Phenotypic Data

In combination with other aberrations

Lethal in combination with Df(4)M101-63a, Df(4)Δ3M or Df(4)Δ9M. Inferred to overlap with: Df(4)M101-63a. Inferred to overlap with: Df(4)Δ3M. Inferred to overlap with: Df(4)Δ9M.

(Kronhamn and Rasmuson-Lestander, 1999)

NOT in combination with other aberrations

Df(4)M101-62f uncovers hybrid sterility when heterozygous in males containing the D.simulans 4th chromosome introgressed into an otherwise D.melanogaster background.

(Masly et al., 2006)

en^-/en⁺ in combination with an unpaired wild type ci⁺ allele shows a ci phenotype.

(Locke and Hanna, 1996)

Homozygous embryos have disconnected tracheae and the oesophagus and pharynx are abnormal. Midgut constrictions do not form, the hindgut is shorter than normal and Malpighian tubules do not elongate normally.

(Harbecke and Lengyel, 1995)

In a Df(4)M101-62f genetic background the mutant phenotype of P{UAS-ptc.J} expressed from Scer\GAL4^71B is enhanced, wing veins L3 and L4 are extensively deleted.

(Johnson et al., 1995)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Stocks (2)

Bloomington

9433

w^*; Df(4)M101-62f/Dp(2;4)ey^D, Ablp^eyD: ey^D

Kyoto

103322

Df(4)M101-62f / Dp(2;4)ey^D, Ablp^eyD ; ey^D

Notes on Origin

Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

Df(4)62f

Df(4)^62f

(Locke et al., 2004)

Df(4)M101-62f

(Li et al., 2020, Sawyer et al., 2020, Gilliland et al., 2015, Ayoob et al., 2006, Masly et al., 2006)

Df(4)M62F

(Smith et al., 1993)

Df(4)M62f

(Apionishev et al., 2005, Cox et al., 2000, Cavallo et al., 1998, Dooijes et al., 1998, Ohlmeyer and Kalderon, 1998, Ohlmeyer and Kalderon, 1997, van de Wetering et al., 1997, Von Ohlen et al., 1997, Leyns et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Dambly-Chaudiere and Leyns, 1992, Orr, 1992)

Df(4)M^62f

(Brunner et al., 1997, Dominguez et al., 1996, Locke and Hanna, 1996, Ayme-Southgate et al., 1995, Locke and Tartof, 1994)

Df-62f

(Kronhamn and Rasmuson-Lestander, 1999)

M101-62f

(Yamaguchi et al., 1999)

M62f

(Leyns et al., 1991)

M^62f

(Hepker et al., 1999, Slusarski et al., 1995, Eaton and Kornberg, 1990)

ci^M62f

(Johnson et al., 1995)

df(4)M62f

(van Beest et al., 1998)

Name Synonyms

Deficiency (4) Minute

Secondary FlyBase IDs

References (41)

Report Sections

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