FlyBase Allele Report: Dmel\PTP-ER[XE-3022]

General Information

Symbol

Dmel\PTP-ER^XE-3022

Species

D. melanogaster

Name

FlyBase ID

FBal0098354

Feature type

allele

Associated gene

Dmel\PTP-ER

Associated Insertion(s)

FB{}PTP-ER^XE-3022

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Karim and Rubin, 1999)

Progenitor genotype

Associated Insertion(s)

FB{}PTP-ER^XE-3022

Cytology

Description

Created by a 4kb foldback (FB) insertion into the catalytic domain of PTP-ER, just downstream of the invariant aspartate residue on the WPD loop. The insertion also generates a 9bp duplication (TCATCACTC) at its insertion site. The insertion creates a stop codon, terminating the PTP-ER 14 residues into the insertion.

(Karim and Rubin, 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:21,620,639..21,620,647 [-]

(Baril and Therrien, 2006, Karim and Rubin, 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Karim and Rubin, 1999)

visible

(Rintelen et al., 2003)

visible | recessive

(Karim and Rubin, 1999)

Phenotype Manifest In

eye

(Karim and Rubin, 1999)

eye photoreceptor cell

(Rintelen et al., 2003, Karim and Rubin, 1999)

ommatidium

(Rintelen et al., 2003, Karim and Rubin, 1999)

photoreceptor cell R7 | ectopic

(Karim and Rubin, 1999)

photoreceptor cell R7 | increased number

(Baril and Therrien, 2006, Rintelen et al., 2003)

Detailed Description

Statement

Reference

PTP-ER^XE-3022 flies have a rough eye phenotype due to ommatidia occasionally containing one or more extra R7 cells, which may be accompanied by loss of an outer photoreceptor cell. R3 and R4 cells are unaffected.

(Rintelen et al., 2003)

Displays a very mild eye roughness due to the recruitment of ectopic R7 cells either when homozygous or when hemizygous with a deficiency for the 57F--58A region.

(Karim and Rubin, 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

PTP-ER[+]/PTP-ER^XE-3022 is an enhancer of visible phenotype of Mkp3¹/Mkp3²

(Rintelen et al., 2003)

PTP-ER^XE-3022 is an enhancer of visible phenotype of Ras85D^V12.sev

(Karim and Rubin, 1999)

Suppressor of

Statement

Reference

PTP-ER^XE-3022 is a suppressor of visible | recessive phenotype of Raf¹²

(Karim and Rubin, 1999)

PTP-ER^XE-3022 is a suppressor of visible | recessive phenotype of ksr^S-548

(Karim and Rubin, 1999)

Other

Statement

Reference

PTP-ER^XE-3022, alph^S-331 has lethal phenotype

(Baril and Therrien, 2006)

Mkp3¹/Mkp3^5J4, PTP-ER^XE-3022, rl^10a has viable phenotype

(Rintelen et al., 2003)

Mkp3¹/Mkp3², PTP-ER^XE-3022 has lethal | pharate adult stage phenotype

(Rintelen et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

PTP-ER^XE-3022/PTP-ER^XE-2776 has photoreceptor cell R7 | increased number phenotype, enhanceable by alph^S-331

(Baril and Therrien, 2006)

Suppressed by

Statement

Reference

PTP-ER^XE-3022, Ras85D^V12.sev has photoreceptor cell R7 phenotype, suppressible by PTP-ER^hs.sev

(Karim and Rubin, 1999)

PTP-ER^XE-3022, Ras85D^V12.sev has photoreceptor neuron phenotype, suppressible by PTP-ER^hs.sev

(Karim and Rubin, 1999)

Enhancer of

Statement

Reference

PTP-ER^XE-3022/PTP-ER^XE-2776 is an enhancer of photoreceptor cell R7 | increased number phenotype of alph^S-331

(Baril and Therrien, 2006)

PTP-ER[+]/PTP-ER^XE-3022 is an enhancer of wing vein | increased number phenotype of Mkp3¹/Mkp3²

(Rintelen et al., 2003)

PTP-ER^XE-3022 is an enhancer of ommatidium phenotype of Ras85D^V12.sev

(Karim and Rubin, 1999)

PTP-ER^XE-3022 is an enhancer of eye phenotype of Ras85D^V12.sev

(Karim and Rubin, 1999)

Suppressor of

Statement

Reference

PTP-ER^XE-3022 is a suppressor of eye phenotype of Raf¹²

(Karim and Rubin, 1999)

PTP-ER^XE-3022 is a suppressor of ommatidium phenotype of Raf¹²

(Karim and Rubin, 1999)

PTP-ER^XE-3022 is a suppressor of photoreceptor neuron phenotype of Raf¹²

(Karim and Rubin, 1999)

PTP-ER^XE-3022 is a suppressor of eye photoreceptor cell phenotype of Dsor1^XS520

(Karim and Rubin, 1999)

PTP-ER^XE-3022 is a suppressor of photoreceptor cell R7 phenotype of Dsor1^XS520

(Karim and Rubin, 1999)

PTP-ER^XE-3022 is a suppressor of ommatidium phenotype of Dsor1^XS520

(Karim and Rubin, 1999)

PTP-ER^XE-3022 is a suppressor of eye phenotype of Dsor1^XS520

(Karim and Rubin, 1999)

PTP-ER^XE-3022 is a suppressor of eye phenotype of ksr^S-548

(Karim and Rubin, 1999)

PTP-ER^XE-3022 is a suppressor of ommatidium phenotype of ksr^S-548

(Karim and Rubin, 1999)

PTP-ER^XE-3022 is a suppressor of photoreceptor neuron phenotype of ksr^S-548

(Karim and Rubin, 1999)

Additional Comments

Genetic Interactions

Statement

Reference

PTP-ER^XE-3022, in a double homozygote combination with alph^S-331 exhibits a synthetic lethality.

PTP-ER^XE-3022/PTP-ER^XE-2776 do not show synthetic lethality when placed in an alph^S-331 homozygous background, however, a significant increase of extra R7 cells is observed compared to the respective single homozygotes.

(Baril and Therrien, 2006)

PTP-ER^XE-3022 ; Mkp3¹/Mkp3² pharate adults have ommatidia characteristic of either single mutant.

(Rintelen et al., 2003)

Dominant enhancer of the Ras85D^V12.sev rough eye phenotype. Heterozygous PTP-ER^XE-3022 suppresses the rough eyes and loss of photoreceptor cells seen in either hemizygous Dsor1^XS520, hemizygous phl¹² or homozygous ksr^S-548. Ectopic expression of PTP-ER^hs.sev in the eye completely blocks the Ras85D^V12.sev rough eye phenotype even in the presence of PTP-ER^XE-3022.

(Karim and Rubin, 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

PTP-ER^XE-3022

(Baril and Therrien, 2006)

PTP-ER^XE3022

(Rintelen et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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