FlyBase Allele Report: Dmel\Dsor1[XS520]

General Information

Symbol

Dmel\Dsor1^XS520

Species

D. melanogaster

Name

FlyBase ID

FBal0034021

Feature type

allele

Associated gene

Dmel\Dsor1

Associated Insertion(s)

Carried in Construct

Also Known As

Dsor1^XS-520

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Karim et al., 1996)

Mutagen

X ray

(Karim et al., 1996)

Progenitor genotype

Cytology

Description

6bp in frame deletion removing M308 and A309 of the kinase subdomain X, both of which are conserved in mammalian MEK.

(Karim et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:9,249,555..9,249,560 [+]

Comment:

Reported as in frame deletion of M308 and A309 in FBrf0087493. Maps to M311 and A312 in the CDS encoded by the reference sequence. The difference is due to the use of an upstream splice acceptor in an upstream intron. The annotated version is supported by full length cDNA LD41207 (GB:AY058692).

(Karim et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Karim et al., 1996)

some die during immature adult stage | recessive

(Karim et al., 1996)

visible

(Lai et al., 1996)

visible | dominant

(Karim et al., 1996)

visible | recessive

(Karim and Rubin, 1999, Lu and Li, 1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

Dsor1^XS520 is a weak mutation which results in a loss of R7 and some outer photoreceptor cells causing mild eye roughness.

(Karim and Rubin, 1999)

Rough eye phenotype resulting from a failure of a proportion of R7 cells and outer photoreceptor cells to differentiate. Parts of some wing veins are missing.

(Karim et al., 1996)

Some ommatidia lack R7 cells. ttk mutations have no significant effect on the severity of the rough eye phenotype.

(Lai et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Dsor1^XS520 has visible phenotype, enhanceable by hh^XE-2134

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, enhanceable by hh^XE-3161

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, enhanceable by ksr^S-627

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, enhanceable by ksr^XS-337

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, enhanceable by mam^S-639

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, enhanceable by mam^XS-2295

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, enhanceable by rl^S-135

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, enhanceable by rl^XS-324

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, enhanceable by SR3-6^S-122

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, enhanceable by SR3-6^XS-328

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, enhanceable by Taf6^XS-922

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, enhanceable by ER2-7B^XE-2337

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, enhanceable by ER2-7B^XE-2457

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, enhanceable by ER3-4^XE-2178

(Karim et al., 1996)

Suppressed by

Statement

Reference

Dsor1^XS520 has visible | recessive phenotype, suppressible by Src42A^Su(Raf)1-1

(Lu and Li, 1999)

Dsor1^XS520 has visible phenotype, suppressible by ER2-1^E-203

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, suppressible by ER2-1^E-33

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, suppressible by ER2-3^XE-2542

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, suppressible by ER2-4^XE-2171

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, suppressible by ER2-4^XE-2866

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, suppressible by ER3-2^XE-2795

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, suppressible by mts^XE-2202

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, suppressible by mts^XE-2258

(Karim et al., 1996)

Dsor1^XS520 has visible phenotype, suppressible by PTP-ER^XE12N

(Karim et al., 1996)

NOT Enhancer of

Statement

Reference

Dsor1^XS520 is a non-enhancer of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Suppressor of

Statement

Reference

Dsor1^XS520 is a suppressor of increased cell number | third instar larval stage phenotype of hop^Tum

(Luo et al., 2002)

NOT Suppressor of

Statement

Reference

Dsor1^XS520 is a non-suppressor of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

Dsor1^XS520 has eye phenotype, enhanceable by hh^XE-2134

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, enhanceable by hh^XE-3161

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, enhanceable by ksr^S-627

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, enhanceable by ksr^XS-337

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, enhanceable by mam^S-639

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, enhanceable by mam^XS-2295

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, enhanceable by rl^S-135

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, enhanceable by rl^XS-324

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, enhanceable by SR3-6^S-122

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, enhanceable by SR3-6^XS-328

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, enhanceable by Taf6^XS-922

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, enhanceable by ER2-7B^XE-2337

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, enhanceable by ER2-7B^XE-2457

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, enhanceable by ER3-4^XE-2178

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, enhanceable by pnt^07825Δ78

(O'Neill et al., 1994)

Dsor1^XS520 has photoreceptor neuron phenotype, enhanceable by pnt^07825Δ78

(O'Neill et al., 1994)

Suppressed by

Statement

Reference

Dsor1^XS520 has ommatidium phenotype, suppressible by PTP-ER^XE-3022

(Karim and Rubin, 1999)

Dsor1^XS520 has eye phenotype, suppressible by PTP-ER^XE-3022

(Karim and Rubin, 1999)

Dsor1^XS520 has eye photoreceptor cell phenotype, suppressible by PTP-ER^XE-2776

(Karim and Rubin, 1999)

Dsor1^XS520 has photoreceptor cell R7 phenotype, suppressible by PTP-ER^XE-2776

(Karim and Rubin, 1999)

Dsor1^XS520 has ommatidium phenotype, suppressible by PTP-ER^XE-2776

(Karim and Rubin, 1999)

Dsor1^XS520 has eye phenotype, suppressible by PTP-ER^XE-2776

(Karim and Rubin, 1999)

Dsor1^XS520 has ommatidium phenotype, suppressible by PTP-ER[-]

(Karim and Rubin, 1999)

Dsor1^XS520 has eye phenotype, suppressible by PTP-ER[-]

(Karim and Rubin, 1999)

Dsor1^XS520 has eye photoreceptor cell phenotype, suppressible by PTP-ER[-]

(Karim and Rubin, 1999)

Dsor1^XS520 has photoreceptor cell R7 phenotype, suppressible by PTP-ER[-]

(Karim and Rubin, 1999)

Dsor1^XS520 has eye photoreceptor cell phenotype, suppressible by PTP-ER^XE-3022

(Karim and Rubin, 1999)

Dsor1^XS520 has photoreceptor cell R7 phenotype, suppressible by PTP-ER^XE-3022

(Karim and Rubin, 1999)

Dsor1^XS520 has eye phenotype, suppressible by Src42A^Su(Raf)1-1

(Lu and Li, 1999)

Dsor1^XS520 has phenotype, suppressible by aop^E-867

(Karim et al., 1996)

Dsor1^XS520 has phenotype, suppressible by aop^yan-XE18

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, suppressible by ER2-1^E-203

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, suppressible by ER2-1^E-33

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, suppressible by ER2-3^XE-2542

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, suppressible by ER2-4^XE-2171

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, suppressible by ER2-4^XE-2866

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, suppressible by ER3-2^XE-2795

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, suppressible by mts^XE-2202

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, suppressible by mts^XE-2258

(Karim et al., 1996)

Dsor1^XS520 has eye phenotype, suppressible by PTP-ER^XE12N

(Karim et al., 1996)

NOT Enhancer of

Statement

Reference

Dsor1^XS520 is a non-enhancer of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Suppressor of

Statement

Reference

Dsor1^XS520 is a suppressor of hemocyte | increased number phenotype of hop^Tum

(Luo et al., 2002)

Dsor1^XS520 is a suppressor of lamellocyte | increased number phenotype of hop^Tum

(Luo et al., 2002)

Dsor1^XS520 is a suppressor of phenotype of Ras85D^V12.sev

(Karim et al., 1996)

Dsor1^XS520 is a suppressor of eye phenotype of Ras85D^V12.sev

(O'Neill et al., 1994)

NOT Suppressor of

Statement

Reference

Dsor1^XS520 is a non-suppressor of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Dsor1^XS520 blocks differentiation of hop^Tum blood cells into lamellocytes and the increased accumulation of blood cells seen in hop^Tum larvae is strongly inhibited in the double mutant larvae.

(Luo et al., 2002)

Heterozygous PTP-ER^XE-3022, PTP-ER^XE-2776 as well as deficiency alleles of PTP-ER suppress the rough eyes and loss of photoreceptor cells seen in hemizygous Dsor1^XS520.

(Karim and Rubin, 1999)

Src42A^Su(phl)1-1 dominantly suppresses the rough eye phenotype of Dsor1^XS520.

(Lu and Li, 1999)

Suppresses the rough eye phenotype of Ras85D^V12.sev. Enhances the phenotype of Ras85D^N17.sev. Suppresses the phenotype of phl::tor^13D.hs.sev. Suppresses the phenotype of Ras85D::Src64B^{V12.ΔCAAX.sev}. Enhances the aop^S2382 eye phenotype.

(Karim et al., 1996)

Acts as a dominant suppressor of the activated Ras85D^V12.sev. Halving the gene dosage of pnt enhances both the rough eye and missing photoreceptor phenotypes of Dsor1^XS520 and phl¹².

(O'Neill et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Dsor1^XS-520

(Luo et al., 2002, Therrien et al., 2000, Karim and Rubin, 1999, Karim et al., 1996)

Dsor1^XS520

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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