FlyBase Allele Report: Dmel\pnt[07825Δ78]

General Information

Symbol

Dmel\pnt^07825Δ78

Species

D. melanogaster

Name

FlyBase ID

FBal0035453

Feature type

allele

Associated gene

Dmel\pnt

Associated Insertion(s)

Carried in Construct

Also Known As

pnt^Δ78, pnt^7825Δ78

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Okabe and Okano, 1997)

Mutagen

P-element activity

(O'Neill et al., 1994)

Progenitor genotype

pnt⁰⁷⁸²⁵

(O'Neill et al., 1994)

Cytology

Description

Imprecise excision of P{PZ}pnt⁰⁷⁸²⁵ has caused a deletion that includes sequence of the P2 isoform specific exon 'iv'.

(O'Neill et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | embryonic stage 15

(Wang et al., 2017)

lethal | recessive

(O'Neill et al., 1994)

Phenotype Manifest In

abdominal 1 lateral pentascolopidial chordotonal organ lch5

(Okabe and Okano, 1997)

abdominal 1 ventral monoscolopidial chordotonal organ vch1

(Okabe and Okano, 1997)

abdominal 2 lateral pentascolopidial chordotonal organ lch5

(Okabe and Okano, 1997)

abdominal 2 ventral monoscolopidial chordotonal organ vch1

(Okabe and Okano, 1997)

abdominal 3 lateral pentascolopidial chordotonal organ lch5

(Okabe and Okano, 1997)

abdominal 3 ventral monoscolopidial chordotonal organ vch1

(Okabe and Okano, 1997)

abdominal 4 lateral pentascolopidial chordotonal organ lch5

(Okabe and Okano, 1997)

abdominal 4 ventral monoscolopidial chordotonal organ vch1

(Okabe and Okano, 1997)

abdominal 5 lateral pentascolopidial chordotonal organ lch5

(Okabe and Okano, 1997)

abdominal 5 ventral monoscolopidial chordotonal organ vch1

(Okabe and Okano, 1997)

abdominal 6 lateral pentascolopidial chordotonal organ lch5

(Okabe and Okano, 1997)

abdominal 6 ventral monoscolopidial chordotonal organ vch1

(Okabe and Okano, 1997)

abdominal 7 lateral pentascolopidial chordotonal organ lch5

(Okabe and Okano, 1997)

abdominal 7 ventral monoscolopidial chordotonal organ vch1

(Okabe and Okano, 1997)

dorsal air sac primordium | somatic clone

(Cabernard and Affolter, 2005)

dorsal appendage | maternal effect | somatic clone

(Lachance et al., 2009, Morimoto et al., 1996)

embryonic/larval oenocyte | embryonic stage 15

(Wang et al., 2017)

eye

(Kurada and White, 1998)

Detailed Description

Statement

Reference

Oenocytes are completely absent in pnt^07825Δ78 homozygous, but not pnt^07825Δ78/pnt^MI03880 transheterozygous stage 15 embryos, unlike in controls.

(Wang et al., 2017)

Adult midgut intestinal stem cell somatic MARCM clones homozygous for pnt^07825Δ78 do not display any growth defects. The rate of mitosis upon infection with Pseudomonas entomophila in the mosaic midgut is comparable to controls.

(Jin et al., 2015)

Eggs derived from egg chambers containing complete homozygous follicle cell clones have a single thick dorsal appendages.

(Lachance et al., 2009)

pnt^07825Δ78 homozygous clones in the dorsal air sac primordium grow and normally but never contribute to the tip of the primordium.

(Cabernard and Affolter, 2005)

In somatic clones mutant for pnt^05484Δ33 in third instar eye discs, some R2-5 photoreceptors undergo G1 arrest, but none differentiate.

(Yang and Baker, 2003)

Homozygous and pnt^07825Δ78/pnt^Δ88 embryos have wild-type midgut development.

(Bilder et al., 1998)

Homozygous embryos show a loss of 3 chordotonal organs per abdominal hemisegment (VChA and two in LCh5).

(Okabe and Okano, 1997)

Eggs laid by mosaic females (generated using Scer\FRT/Scer\FLP1 recombination system) that have a clone of mutant follicle cells in the dorsal-anterior region or a clone that covers the entire follicle cell layer exhibit a single broad dorsal appendage 4 times wider than a wild type appendage. This is not a fusion of the two appendages but cells from the middle region taking on an appendage-producing cell fate.

(Morimoto et al., 1996)

Clones in the eye are missing photoreceptors.

(O'Neill et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

pnt^07825Δ78 is an enhancer of visible phenotype of BacA\p35^GMR.PH, Dp^GMR.PD, E2f1^GMR.PD

(Staehling-Hampton et al., 1999)

Phenotype Manifest In

Enhancer of

Statement

Reference

pnt^07825Δ78 is an enhancer of eye phenotype of hid^GMR.PG

(Kurada and White, 1998)

pnt^07825Δ78 is an enhancer of eye phenotype of Raf¹²

(O'Neill et al., 1994)

pnt^07825Δ78 is an enhancer of photoreceptor neuron phenotype of Raf¹²

(O'Neill et al., 1994)

pnt^07825Δ78 is an enhancer of eye phenotype of Dsor1^XS520

(O'Neill et al., 1994)

pnt^07825Δ78 is an enhancer of photoreceptor neuron phenotype of Dsor1^XS520

(O'Neill et al., 1994)

Suppressor of

Statement

Reference

pnt^07825Δ78 is a suppressor of ommatidium phenotype of aop^A141

(Rohrbaugh et al., 2002)

pnt^07825Δ78 is a suppressor of photoreceptor cell R1 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

pnt^07825Δ78 is a suppressor of photoreceptor cell R2 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

pnt^07825Δ78 is a suppressor of photoreceptor cell R3 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

pnt^07825Δ78 is a suppressor of photoreceptor cell R4 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

pnt^07825Δ78 is a suppressor of photoreceptor cell R5 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

pnt^07825Δ78 is a suppressor of photoreceptor cell R6 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

pnt^07825Δ78 is a suppressor of eye phenotype of Ras85D^V12.sev

(O'Neill et al., 1994)

NOT Suppressor of

Statement

Reference

pnt^07825Δ78 is a non-suppressor of photoreceptor cell R7 phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The growth of intestinal stem cell somatic MARCM clones expressing cic^KK100838 under the control of Scer\GAL4^tub.PU in the adult midgut is not reduced by combination with pnt^07825Δ78.

(Jin et al., 2015)

Weakly enhances the phenotype of E2f^GMR.PD Dp^GMR.PD BacA\p35^GMR.PH flies.

(Staehling-Hampton et al., 1999)

pnt^07825Δ78 significantly suppresses the formation of extra outer photoreceptors caused by B-H1^sev.PH, although it does not affect the loss of R7 cell phenotype caused by B-H1^sev.PH.

(Hayashi et al., 1998)

Enhances the eye reduction phenotype caused by W^GMR.PG.

(Kurada and White, 1998)

pnt^07825Δ78 acts as a dominant suppressor of the eye phenotype of the activated Ras85D^V12.sev. Halving the gene dosage of pnt enhances both the rough eye and missing photoreceptor phenotypes of Dsor1^XS520 and phl¹².

(O'Neill et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

pnt^ksh-14

(Staehling-Hampton et al., 1999)

pnt^pjc-5

(Staehling-Hampton et al., 1999)

pnt^pjc-6

(Staehling-Hampton et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

pnt-P2

(Yang and Baker, 2003)

pnt^07825Δ78

pnt^7825Δ78

(Rebay et al., 2000, Hayashi et al., 1998, Okabe, 1998.10.3)

pnt^7848Δ78

pnt^P2

(Okabe and Okano, 1997)

pnt^Δ78

(Wang et al., 2017, Jin et al., 2015, Shwartz et al., 2013, Lachance et al., 2009, Yang and Baker, 2003, Rohrbaugh et al., 2002, Bilder et al., 1998, Kurada and White, 1998, Morimoto et al., 1996)

pnt^ΔP78

(Cabernard and Affolter, 2005)

Name Synonyms

Secondary FlyBase IDs

FBal0059967

References (16)

Report Sections

Open Close