FlyBase Allele Report: Dmel\mts[XE-2258]

General Information

Symbol

Dmel\mts^XE-2258

Species

D. melanogaster

Name

FlyBase ID

FBal0048909

Feature type

allele

Associated gene

Dmel\mts

Associated Insertion(s)

Carried in Construct

Also Known As

mts^XE2258

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Karim et al., 1996, Wassarman et al., 1996)

Progenitor genotype

Cytology

Description

16bp deletion, bases -7 to 9, that spans the translation start site. The next in-frame methionine does not occur for another 66 amino acids.

(Wassarman et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2L:7,828,045..7,828,060 [+]

Comment:

A 16 bp deletion that spans the translation start site.

(Wassarman et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^UAS.cBa

(Tziortzouda et al., 2024)

modeled by Hsap\FUS^{R521G.UAS.cBa}

(Tziortzouda et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy (with mts²⁹⁹)

(Wang et al., 2009)

lethal (with Df(2L)BSC142)

(Kahsai and Cook, 2018, Kahsai et al., 2016)

lethal | recessive

(Kotadia et al., 2008, Karim et al., 1996)

lethal - all die during embryonic stage | recessive

(Wassarman et al., 1996)

some die during embryonic stage | recessive

(Wassarman et al., 1996)

Phenotype Manifest In

neuroblast | increased number (with mts²⁹⁹)

(Wang et al., 2009)

Detailed Description

Statement

Reference

mts^XE-2258/+ mutants do not display any apparent phenotype in the thorax or wings of adult flies, nor any significant difference in survival rate, as compared to controls.

(Wang et al., 2012)

mts⁰²⁴⁹⁶/mts^XE-2258 mutant embryos do not exhibit any defects in neuroblast division at stage 10 of embryogenesis.

mts⁰²⁴⁹⁶/mts^XE-2258 mitotic neuroblasts display normal mira localisation.

(Ogawa et al., 2009)

Homozygous clones are not recovered in the eye. Germ line clones reveal that oogenesis is blocked at stage 5.

(Wassarman et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

mts^XE-2258/mts[+], polo¹¹ has partially lethal - majority die | dominant | maternal effect | embryonic stage phenotype, suppressible by gwl[+]/gwl^6a

(Wang et al., 2011)

mts^XE-2258/mts[+], polo¹¹ has partially lethal - majority die | dominant | maternal effect | embryonic stage phenotype, suppressible by gwl[+]/gwl^Sr18

(Wang et al., 2011)

Enhancer of

Statement

Reference

mts^XE-2258 is an enhancer of abnormal cell polarity phenotype of Scer\GAL4^GMR.PF, aPKC^{UAS.Tag:CAAX(Unk)}

(Ogawa et al., 2009)

mts^XE-2258 is an enhancer of visible phenotype of Scer\GAL4^ptc-559.1, smo^RNAi.UAS.WIZ

(Casso et al., 2008)

mts^XE-2258/mts[+] is an enhancer of lethal | embryonic stage phenotype of SV40\ST^{UASp.Tag:FLAG}, Scer\GAL4^{VP16.nanos.UTR}

(Kotadia et al., 2008)

Suppressor of

Statement

Reference

mts^XE-2258/mts[+] is a suppressor | partially of visible phenotype of Scer\GAL4^ap-md544, Tap42^GD8900

(Wang et al., 2012)

mts^XE-2258/mts[+] is a suppressor of partially lethal - majority die phenotype of Scer\GAL4^ap-md544, Tap42^GD8900

(Wang et al., 2012)

mts^XE-2258/mts[+] is a suppressor of visible | dominant phenotype of hh^Mrt

(Casso et al., 2008)

mts^XE-2258/mts[+] is a suppressor of abnormal neurophysiology | semidominant phenotype of inaC²

(Wang et al., 2008)

mts^XE-2258 is a suppressor of visible phenotype of Dsor1^XS520

(Karim et al., 1996)

NOT Suppressor of

Statement

Reference

mts^XE-2258/mts[+] is a non-suppressor of abnormal neurophysiology | semidominant phenotype of inaC²

(Wang et al., 2008)

mts^XE-2258/mts[+] is a non-suppressor of abnormal neurophysiology | recessive phenotype of inaC²

(Wang et al., 2008)

mts^XE-2258/mts[+] is a non-suppressor of abnormal neurophysiology phenotype of norpA^P16

(Wang et al., 2008)

Other

Statement

Reference

mts^XE-2258/mts[+], polo¹¹ has partially lethal - majority die | dominant | maternal effect | embryonic stage phenotype

(Wang et al., 2011)

gwl^scant, mts^XE-2258/mts[+] has lethal | dominant | maternal effect | embryonic stage phenotype

(Wang et al., 2011)

l(2)gl^ts3/l(2)gl⁴, mts^XE-2258 has abnormal eclosion rhythm phenotype

(Ogawa et al., 2009)

Phenotype Manifest In

Enhancer of

Statement

Reference

mts^XE-2258/mts[+] is an enhancer of centrosome | embryonic stage 4 | maternal effect phenotype of polo¹¹

(Wang et al., 2011)

mts^XE-2258 is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, aPKC^{UAS.Tag:CAAX(Unk)}

(Ogawa et al., 2009)

mts^XE-2258 is an enhancer of mechanosensory chaeta | heat sensitive phenotype of l(2)gl^ts3/l(2)gl⁴

(Ogawa et al., 2009)

mts^XE-2258 is an enhancer of wing vein phenotype of Scer\GAL4^ptc-559.1, smo^RNAi.UAS.WIZ

(Casso et al., 2008)

mts^XE-2258/mts[+] is an enhancer of centrosome | increased number phenotype of SV40\ST^{UASp.Tag:FLAG}, Scer\GAL4^{VP16.nanos.UTR}

(Kotadia et al., 2008)

mts^XE-2258 is an enhancer of phenotype of Ras85D^V12.sev

(Karim et al., 1996)

mts^XE-2258 is an enhancer of eye phenotype of Ras85D^V12.sev

(Wassarman et al., 1996)

mts^XE-2258 is an enhancer of eye phenotype of Raf¹²

(Wassarman et al., 1996)

Suppressor of

Statement

Reference

mts^XE-2258/mts[+] is a suppressor | partially of adult thorax phenotype of Scer\GAL4^ap-md544, Tap42^GD8900

(Wang et al., 2012)

mts^XE-2258/mts[+] is a suppressor | partially of wing | adult stage phenotype of Scer\GAL4^ap-md544, Tap42^GD8900

(Wang et al., 2012)

mts^XE-2258/mts[+] is a suppressor of wing phenotype of hh^Mrt

(Casso et al., 2008)

mts^XE-2258 is a suppressor of wing hair | increased number phenotype of Scer\GAL4^ap-md544, wdb^EP3559

(Hannus et al., 2002)

mts^XE-2258 is a suppressor of eye phenotype of Dsor1^XS520

(Karim et al., 1996)

mts^XE-2258 is a suppressor of eye phenotype of Raf¹²

(Karim et al., 1996)

mts^XE-2258 is a suppressor of eye phenotype of Raf::tor^13D.hs.sev

(Wassarman et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

mts^XE-2258/+ partially rescues the cleft thorax and wing phenotypes, and rescues survival of flies expressing Tap42^GD8900 under the control of Scer\GAL4^ap-md544.

(Wang et al., 2012)

Compared with wild-type controls, a lower than expected proportion of the embryos hatch resulting from the cross between polo¹¹/+, mts^XE-2258/+ mothers and wild-type fathers.

The embryos from mothers heterozygous polo¹¹ and mts^XE-2258, of which a minority are able to hatch into larvae, show a high frequency of detached centrosomes at any stage of the mitotic cycles.

The embryos resulting from the cross between gwl^scant/+, mts^XE-2258/+ mothers and wild-type fathers fail to hatch.

gwl^6a/+ partially rescues the viability of embryos from mts^XE-2258/+, polo¹¹/+ mothers.

gwl^Sr18/+ partially rescues the viability of embryos from mts^XE-2258/+, polo¹¹/+ mothers.

(Wang et al., 2011)

The addition of one copy of mts^XE-2258 to l(2)gl⁴/l(2)gl^ts3 flies reduces the eclosion rate to 72% and 42% respectively.

The presence of one copy of mts^XE-2258 in l(2)gl⁴/l(2)gl^ts3 flies increases the frequency of defective bristle formation to 33% and 64% respectively (compared to 28% in l(2)gl⁴/l(2)gl^ts3 mutants).

(Ogawa et al., 2009)

The deactivation defect seen in inaC² heterozygotes is rescued in a mts^XE-2258 heterozygous background. Contrarily, heterozygosity of mts^XE-2258 fails to rescue the inactivation defect of inaC² homozygotes. inaC² heterozygotes and homozygotes display a deficiency in light adaptation, which fails to be rescued in both genotypes when in combination with mts^XE-2258/+.

The homozygous norpA³⁵ deactivation defects are not rescued when in combination with mts^XE-2258/+.

(Wang et al., 2008)

Enhances the rough eye phenotype of Ras85D^V12.sev. Has little or no effect on the phenotype of Ras85D^N17.sev. Enhances the phenotype of phl::tor^13D.hs.sev. Enhances the phenotype of Ras85D::Src64B^{V12.ΔCAAX.sev}. Has little or no effect on the lethality of phl¹². Suppresses the phl¹² eye phenotype. Suppresses the Dsor1^XS520 eye phenotype.

(Karim et al., 1996)

Weak enhancer of rough eye phenotype of Ras85D^V12.sev. Weakly suppresses the rough eye phenotype of phl::tor^13D.hs.sev. Dominantly enhances the phenotype of phl¹².

(Wassarman et al., 1996)

Xenogenetic Interactions

Statement

Reference

The neuronal degeneration phenotype and decreased survival of animals expressing Hsap\HD^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155 is modestly suppressed in a mts^XE-2258/+ mutant background, but the effect is not statistically significant.

(Maher et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

5684

mts^XE-2258/CyO, P{sevRas1.V12}FK1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Pp2A-28D²²⁵⁸

(Wassarman et al., 1996)

Pp2A-28D^XE-2258

mts2258

(Hannus et al., 2002)

mts^EX2258

(Zhang et al., 2016)

mts^XE-2258

(Gil-Ranedo et al., 2019, Kim et al., 2019, Kahsai and Cook, 2018, Chen et al., 2016, Zhang et al., 2016, White-Grindley et al., 2014, Maher et al., 2011, Wang et al., 2011, Salzer et al., 2010, Ogawa et al., 2009, Wang et al., 2009, Casso et al., 2008, Christensen and Cook, 2006.8.29, Christensen and Cook, 2006.8.29, Christensen and Cook, 2006.8.29, Christensen and Cook, 2006.12.5)

mts^XE2258

(Tziortzouda et al., 2024, Gil-Ranedo et al., 2019, Wang et al., 2012, Wang et al., 2008)

mts^xe2258

(Rui et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (27)

Report Sections

Open Close