The defects seen in embryos derived from females expressing mtrm^{Scer\UAS.FL.T:Zzzz\FLAG} under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} show higher penetrance and are more severe if the females are also heterozygous for polo¹¹.

No adult progeny are recovered from polo¹¹/+ gwl^scant/+ double heterozygous females mated to wild-type males.

The embryos resulting from the cross between polo¹¹/+, Df(3R)ED5474/+ mothers and wild-type fathers fail to hatch.

Compared with wild-type controls, a lower than expected proportion of the embryos hatch resulting from the cross between polo¹¹/+, Df(2L)ED12527/+ mothers and wild-type fathers.

Compared with wild-type controls, a lower than expected proportion of the embryos hatch resulting from the cross between polo¹¹/+, Df(2L)ED1315/+ mothers and wild-type fathers.

Compared with wild-type controls, a lower than expected proportion of the embryos hatch resulting from the cross between polo¹¹/+, Df(3L)ED4483/+ mothers and wild-type fathers.

Compared with wild-type controls, a lower than expected proportion of the embryos hatch resulting from the cross between polo¹¹/+, Df(3L)ED4486/+ mothers and wild-type fathers.

Compared with wild-type controls, a lower than expected proportion of the embryos hatch resulting from the cross between polo¹¹/+, Df(3R)ED5330/+ mothers and wild-type fathers.

The embryos resulting from the cross between polo¹¹/+, tws^j11C8 mothers and wild-type fathers fail to hatch. These embryos abort very early during syncitial divisions with most or all centrosomes detached already in the first few cycles.

The embryos resulting from the cross between polo¹¹/+, tws^aar-1 mothers and wild-type fathers fail to hatch.

Compared with wild-type controls, a lower than expected proportion of the embryos hatch resulting from the cross between polo¹¹/+, mts^XE-2258/+ mothers and wild-type fathers.

The embryos from mothers heterozygous polo¹¹ and mts^XE-2258, of which a minority are able to hatch into larvae, show a high frequency of detached centrosomes at any stage of the mitotic cycles.

The embryos resulting from the cross between polo¹¹/+, Pp2A-29B^EP2332/+ mothers and wild-type fathers hatch at wild-type rates.

gwl^6a/+ partially rescues the viability of embryos from mts^XE-2258/+, polo¹¹/+ mothers.

gwl^Sr18/+ partially rescues the viability of embryos from mts^XE-2258/+, polo¹¹/+ mothers.

The majority of embryos laid by mothers heterozygous for polo¹¹ and overexpressing Map205^{Scer\UAS.T:Hsap\MYC} in the germ-line driven by Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} fail to hatch. These embryos display a very high percentage of mitoses in which a single centrosome is detached from the nuclear envelope in prophase. This defect is extremely rare in wild-type embryos.

Embryos laid by mothers heterozygous for polo¹¹ and overexpressing Map205^{S283E.Scer\UAS.T:Hsap\MYC} in the germ-line driven by Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} hatch at a normal rate compared to wild-type controls. These embryos display a low but significant percentage of mitoses in which a single centrosome is detached from the nuclear envelope in prophase. This defect is extremely rare in wild-type embryos.

The majority of embryos laid by mothers heterozygous for polo¹¹ and overexpressing Map205^{S283A.Scer\UAS.T:Hsap\MYC} in the germ-line driven by Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} fail to hatch. These embryos display a very high percentage of mitoses in which a single centrosome is detached from the nuclear envelope in prophase. This defect is extremely rare in wild-type embryos.

The frequency of single centrosome detachment observed in embryos laid by mothers heterozygous for polo¹¹ is suppressed by heterozygosity for Df(3R)A4-4L8.

Females heterozygous for both polo¹¹ and gwl^scant lay eggs that die during development. These females lay normal numbers of eggs that do not hatch but do begin to develop and turn brown.

polo¹¹ gwl^scant mitotic nuclei exhibit centrosomal loss in approximately 90% of syncytial embryos.

polo¹¹ gwl^scant double heterozygous females produce embryos that frequently display centrosome disassociation from one pole. There is a slight but significant increase in defective spindles in embryos derived from polo¹¹ gwl^scant mutants compared to controls, indicating that a single mutant copy of these genes in mothers leads to mitotic defects at a low frequency.

polo¹¹ gwl^scant double heterozygous-derived embryos show an initial detachment of one centrosome early in mitosis, before nuclear envelope breakdown. The free centrosome drifts away from the nucleus, and astral microtubule formation usually appears normal, though there is no asymmetric microtubule enhancement. A half-spindle is established by microtubules forming connections between the chromosomes and the centrosome still associated with the nuclear envelope. However, spindle bipolarity is often attained by microtubules growing from the chromosomes outwards. If a free centrosome is sufficiently close to this second half-spindle, it can reattach it to form a normal bipolar spindle containing two centrosomes and nuclear division completes normally. However, if the free centrosome drifts too far away from its spindle, it cannot be recaptured, and the monoastral spindle that forms initially is unfocussed at the pole lacking a centrosome. In some cases, monoastral bipolar spindles fuse with neighboring spindles and degenerate to give interconnecting arrays of microtubules. In other cases, the acentrosomal pole eventually focuses and anaphase occurs.

Female germline expression of gwl^L.Scer\UAS (under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16}) in polo¹¹ heterozygous females allows partial egg hatch (around 4%), and these embryos also show loss of centrosomes from spindles in early syncytial divisions.

Female germline expression of gwl^{K97M.Scer\UAS} (under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16}) in polo¹¹ heterozygotes causes complete sterility. These embryos show loss of centrosomes from very early mitotic spindles.