FlyBase Allele Report: Dmel\rl[S-135]

General Information

Symbol

Dmel\rl^S-135

Species

D. melanogaster

Name

FlyBase ID

FBal0050337

Feature type

allele

Associated gene

Dmel\rl

Associated Insertion(s)

Carried in Construct

Also Known As

rl^s135

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Karim et al., 1996)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Karim et al., 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

rl^S-135 is an enhancer of visible phenotype of PTP-ER^hs.sev

(Karim and Rubin, 1999)

rl^S-135 is an enhancer of lethal phenotype of Raf¹²

(Karim et al., 1996)

rl^S-135 is an enhancer of visible phenotype of Dsor1^XS520

(Karim et al., 1996)

NOT Enhancer of

Statement

Reference

rl^S-135 is a non-enhancer of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

rl^S-135 is a non-enhancer of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

NOT Suppressor of

Statement

Reference

rl^S-135 is a non-suppressor of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

rl^S-135 is a non-suppressor of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Other

Statement

Reference

Egfr^f24, pnt^p2, rl^S-135 has visible | adult stage phenotype

(Wu et al., 2020)

Egfr^f24, pnt^p3/pnt^p2, rl^S-135 has decreased cell number phenotype

(Wu et al., 2020)

Egfr^f24, pnt^p3/pnt^p2, rl^S-135 has visible | adult stage phenotype

(Wu et al., 2020)

Egfr^f24, pnt^p3, rl^S-135 has visible | adult stage phenotype

(Wu et al., 2020)

Egfr^f24, pnt^p3, rl^S-135 has lethal - all die before end of P-stage | temperature conditional phenotype

(Wu et al., 2020)

Phenotype Manifest In

Enhancer of

Statement

Reference

rl^S-135 is an enhancer of eye phenotype of PTP-ER^hs.sev

(Karim and Rubin, 1999)

rl^S-135 is an enhancer of ommatidium phenotype of PTP-ER^hs.sev

(Karim and Rubin, 1999)

rl^S-135 is an enhancer of eye phenotype of Raf¹²

(Karim et al., 1996)

rl^S-135 is an enhancer of eye phenotype of Dsor1^XS520

(Karim et al., 1996)

NOT Enhancer of

Statement

Reference

rl^S-135 is a non-enhancer of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

rl^S-135 is a non-enhancer of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Suppressor of

Statement

Reference

rl[+]/rl^S-135 is a suppressor | partially of eye | ectopic phenotype of Scer\GAL4^dpp.blk1, eya^S-A.UAS

(Hsiao et al., 2001)

rl^S-135 is a suppressor of eye | ectopic phenotype of Scer\GAL4^dpp.blk1, eya^UAS.cHa

(Hsiao et al., 2001)

rl^S-135 is a suppressor of wing phenotype of Scer\GAL4^dpp.PH, eya^UAS.cHa

(Hsiao et al., 2001)

rl^S-135 is a suppressor of phenotype of Ras85D^V12.sev

(Karim et al., 1996)

NOT Suppressor of

Statement

Reference

rl^S-135 is a non-suppressor of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

rl^S-135 is a non-suppressor of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Other

Statement

Reference

Egfr^f24, pnt^p2, rl^S-135 has wing margin phenotype

(Wu et al., 2020)

Egfr^f24, pnt^p3/pnt^p2, rl^S-135 has wing margin phenotype

(Wu et al., 2020)

Egfr^f24, pnt^p3/pnt^p2, rl^S-135 has eye photoreceptor cell | decreased number phenotype

(Wu et al., 2020)

Egfr^f24, pnt^p3, rl^S-135 has wing margin phenotype

(Wu et al., 2020)

da², rl^S-135 has follicle cell phenotype

(Smith et al., 2002)

da², rl[+]/rl^S-135 has follicle cell phenotype

(Smith et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The penetrance of ectopic eye induction in eya^Scer\UAS.cHa; Scer\GAL4^dpp.blk1 flies is reduced from 98% (n=298) to 50% (n=313) by heterozygosity for rl^S-135 and to 58% (n=313) (data from a single, 'strong' P{UAS-eya.H} insertion). The penetrance of ectopic eye induction in eya^S-A.Scer\UAS; Scer\GAL4^dpp.blk1 flies is reduced from 42% (n=306) to 13% (n=310) by heterozygosity for rl^S-135 (data from a single, 'strong' P{UAS-eya^S-A} insertion). The penetrance of ectopic eye induction in eya^S-A.Scer\UAS; Scer\GAL4^dpp.blk1 flies is reduced from 42% (n=306) to 20% (n=304) by heterozygosity for eya^G130 (data from a single, 'strong' P{UAS-eya^S-A} insertion). The proportion of eya^Scer\UAS.cHa; Scer\GAL4^dpp.PH flies with blistered wings (76%) is decreased by heterozygosity for rl^S-135 to 10%, while the proprotion with only mild wing defects is increased from 24% to 90%. (All data from experiments with a single, 'strong' P{UAS-eya.H} insertion; n=approximately 300 in each case).

(Hsiao et al., 2001)

Double heterozygotes rl^S-135/PTP-ER^hs.sev give a stronger eye phenotype than PTP-ER^hs.sev alone.

(Karim and Rubin, 1999)

Suppresses the rough eye phenotype of Ras85D^V12.sev. Enhances the phenotype of Ras85D^N17.sev. Suppresses the phenotype of phl::tor^13D.hs.sev. Suppresses the phenotype of Ras85D::Src64B^{V12.ΔCAAX.sev}. Enhances the lethality of phl¹². Enhances the phl¹² eye phenotype. Enhances the Dsor1^XS520 eye phenotype. Enhances the aop^S2382 eye phenotype.

(Karim et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

rl^S-135

rl^S135

(Wu et al., 2020)

rl^SR135

(Hsiao et al., 2001)

rl^s135

(Sullivan and Rubin, 2002)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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