FlyBase Allele Report: Dmel\PTP-ER[hs.sev]

General Information

Symbol

Dmel\PTP-ER^hs.sev

Species

D. melanogaster

Name

FlyBase ID

FBal0098353

Feature type

allele

Associated gene

Dmel\PTP-ER

Associated Insertion(s)

Carried in Construct

P{hs.sev-PTP-ER.K}

Key Links

Transgenic product class

cDNA

(Karim and Rubin, 1999)

wild_type

(Karim and Rubin, 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Karim and Rubin, 1999)

wild_type

(Karim and Rubin, 1999)

Mutagen

in vitro construct

(Karim and Rubin, 1999)

Progenitor genotype

Carried in construct

P{hs.sev-PTP-ER.K}

Cytology

Description

Wild type PTP-ER cDNA is expressed under the control of the sev enhancer.

(Karim and Rubin, 1999)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

sev

Encoded product / tool

PTP-ER

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | adult stage

(Kim et al., 2004)

decreased size | adult stage

(Kim et al., 2004)

visible

(Karim and Rubin, 1999)

visible | adult stage

(Kim et al., 2004)

Phenotype Manifest In

eye

(Kim et al., 2004, Karim and Rubin, 1999)

eye photoreceptor cell

(Karim and Rubin, 1999)

eye photoreceptor cell | adult stage | decreased number

(Kim et al., 2004)

ommatidium

(Karim and Rubin, 1999)

ommatidium | adult stage

(Kim et al., 2004)

photoreceptor cell R7

(Karim and Rubin, 1999)

Detailed Description

Statement

Reference

Overexpression of PTP-ER^hs.sev gives a small rough eye phenotype, the severity of which varies with the P{hs.sev-PTP-ER.K} line used. The rough exterior morphology is caused by the failure of photoreceptor differentiation, with nearly every ommatidia missing R7 and one or more of the outer photoreceptor cells.

(Karim and Rubin, 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

PTP-ER^hs.sev has decreased cell number | adult stage phenotype, enhanceable by Mkp3^UAS.cKa/Scer\GAL4^sev.PU

(Kim et al., 2004)

PTP-ER^hs.sev has decreased size | adult stage phenotype, enhanceable by Mkp3^UAS.cKa/Scer\GAL4^sev.PU

(Kim et al., 2004)

PTP-ER^hs.sev has visible | adult stage phenotype, enhanceable by Mkp3^UAS.cKa/Scer\GAL4^sev.PU

(Kim et al., 2004)

PTP-ER^hs.sev has visible phenotype, enhanceable by rl^S-135

(Karim and Rubin, 1999)

Suppressed by

Statement

Reference

PTP-ER^hs.sev has visible phenotype, suppressible by rl^Sem

(Karim and Rubin, 1999)

Enhancer of

Statement

Reference

PTP-ER^hs.sev is an enhancer of visible | adult stage phenotype of Mkp3^UAS.cKa, Scer\GAL4^sev.PU

(Kim et al., 2004)

PTP-ER^hs.sev is an enhancer of decreased cell number | adult stage phenotype of Mkp3^UAS.cKa, Scer\GAL4^sev.PU

(Kim et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

PTP-ER^hs.sev has eye phenotype, enhanceable by Mkp3^UAS.cKa/Scer\GAL4^sev.PU

(Kim et al., 2004)

PTP-ER^hs.sev has eye photoreceptor cell | adult stage | decreased number phenotype, enhanceable by Mkp3^UAS.cKa/Scer\GAL4^sev.PU

(Kim et al., 2004)

PTP-ER^hs.sev has ommatidium | adult stage phenotype, enhanceable by Mkp3^UAS.cKa/Scer\GAL4^sev.PU

(Kim et al., 2004)

PTP-ER^hs.sev has eye phenotype, enhanceable by rl^S-135

(Karim and Rubin, 1999)

PTP-ER^hs.sev has ommatidium phenotype, enhanceable by rl^S-135

(Karim and Rubin, 1999)

PTP-ER^hs.sev has phenotype, enhanceable by Ras85D^unspecified

(Karim and Rubin, 1999)

PTP-ER^hs.sev has phenotype, enhanceable by ksr^unspecified

(Karim and Rubin, 1999)

PTP-ER^hs.sev has phenotype, enhanceable by Raf^unspecified

(Karim and Rubin, 1999)

Suppressed by

Statement

Reference

PTP-ER^hs.sev has eye phenotype, suppressible by rl^Sem

(Karim and Rubin, 1999)

PTP-ER^hs.sev has ommatidium phenotype, suppressible by rl^Sem

(Karim and Rubin, 1999)

PTP-ER^hs.sev has photoreceptor cell R7 phenotype, suppressible by rl^Sem

(Karim and Rubin, 1999)

PTP-ER^hs.sev has photoreceptor neuron phenotype, suppressible by rl^Sem

(Karim and Rubin, 1999)

Enhancer of

Statement

Reference

PTP-ER^hs.sev is an enhancer of eye phenotype of Mkp3^UAS.cKa, Scer\GAL4^sev.PU

(Kim et al., 2004)

PTP-ER^hs.sev is an enhancer of eye photoreceptor cell | adult stage | decreased number phenotype of Mkp3^UAS.cKa, Scer\GAL4^sev.PU

(Kim et al., 2004)

Suppressor of

Statement

Reference

PTP-ER^hs.sev is a suppressor of photoreceptor cell R7 phenotype of PTP-ER^XE-3022, Ras85D^V12.sev

(Karim and Rubin, 1999)

PTP-ER^hs.sev is a suppressor of photoreceptor neuron phenotype of PTP-ER^XE-3022, Ras85D^V12.sev

(Karim and Rubin, 1999)

PTP-ER^hs.sev is a suppressor of photoreceptor cell R7 phenotype of Ras85D^V12.sev

(Karim and Rubin, 1999)

PTP-ER^hs.sev is a suppressor of photoreceptor neuron phenotype of Ras85D^V12.sev

(Karim and Rubin, 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Ectopic expression of PTP-ER^hs.sev in this way completely blocks the Ras85D^V12.sev rough eye phenotype even in the presence of PTP-ER^XE-3022. Double heterozygotes rl^S-135/PTP-ER^hs.sev give a stronger eye phenotype than PTP-ER^hs.sev alone. rl^Sem completely suppresses the PTP-ER^hs.sev phenotype, to the point of producing ectopic R7 cells as seen in mutants in rl^Sem alone.

(Karim and Rubin, 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

5775

P{hs.sev-PTP-ER.K}101, w^*

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

PTP-ER^hs.sev

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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