FlyBase Allele Report: Dmel\ebi[E90]

General Information

Symbol

Dmel\ebi^E90

Species

D. melanogaster

Name

FlyBase ID

FBal0096972

Feature type

allele

Associated gene

Dmel\ebi

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Dong et al., 1999)

Mutagen

ethyl methanesulfonate

(Dong et al., 1999)

Progenitor genotype

Cytology

Description

Amino acid replacement: C510Y. Nucleotide substitution: the TGC codon encoding C510 is changed to TAC.

(Dong et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:417,060..417,060 [+]

Nucleotide change:

G417060A

Amino acid change:

C510Y | ebi-PA

(Dong et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oxidative stress response (with ebi^P7)

(Lim et al., 2012)

cell lethal | larval stage | somatic clone

(Marygold et al., 2011)

female semi-sterile | recessive

(Dong et al., 1999)

lethal (with ebi^CCS-8)

(Marygold et al., 2011)

lethal (with ebi^P7)

(Marygold et al., 2011)

lethal (with ebi^WKS-24)

(Marygold et al., 2011)

lethal | recessive

(Marygold et al., 2011)

visible | recessive

(Dong et al., 1999)

Phenotype Manifest In

embryo

(Dong et al., 1999)

eye

(Dong et al., 1999)

macrochaeta

(Dong et al., 1999)

photoreceptor neuron

(Dong et al., 1999)

wing vein

(Dong et al., 1999)

Detailed Description

Statement

Reference

ebi^P7/ebi^E90 escaper flies are more sensitive to paraquat treatment than controls.

(Lim et al., 2012)

No or very few ebi^E90 clones survive to late third instar stage when induced at 48 hours after egg deposition (AED), and survival is not improved by inducing clones in a Minute/+ background. Clones induced at 72 hours AED do survive, but are very small.

(Marygold et al., 2011)

ebi^P7/ebi^E90 flies are viable and show phenotypes similar to weak loss of function Egfr alleles including partial female sterility resulting from partially ventralized eggs, wing vein defects, short bristles and rough eyes.

(Dong et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

ebi^E90/ebi^P7 has abnormal oxidative stress response phenotype, suppressible by Jra¹/Jra[+]

(Lim et al., 2012)

Enhancer of

Statement

Reference

ebi^E90/ebi[+] is an enhancer of abnormal size phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Marygold et al., 2011)

ebi^E90/ebi[+] is an enhancer of abnormal size phenotype of Scer\GAL4^Bx-MS1096, aos^UAS.cMa

(Marygold et al., 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

ebi^E90/ebi[+] is an enhancer of wing phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Marygold et al., 2011)

ebi^E90/ebi[+] is an enhancer of wing vein phenotype of Scer\GAL4^Bx-MS1096, aos^UAS.cMa

(Marygold et al., 2011)

ebi^E90/ebi[+] is an enhancer of wing margin phenotype of sd^ETX4

(Marygold et al., 2011)

ebi^E90/ebi[+] is an enhancer of ommatidium phenotype of Sos^JC2, sev⁶

(Dong et al., 1999)

ebi^E90/ebi[+] is an enhancer of photoreceptor cell R7 phenotype of Sos^JC2, sev⁶

(Dong et al., 1999)

ebi^E90/ebi[+] is an enhancer of ommatidium phenotype of Sos^JC2/Sos[+], sev⁶

(Dong et al., 1999)

ebi^E90/ebi[+] is an enhancer of photoreceptor cell R7 phenotype of Sos^JC2/Sos[+], sev⁶

(Dong et al., 1999)

ebi^E90 is an enhancer of eye phenotype of rux³

(Dong et al., 1999)

Suppressor of

Statement

Reference

ebi^E90 is a suppressor of sex comb phenotype of Pc¹

(Strübbe et al., 2011)

ebi^E90 is a suppressor of metathoracic leg phenotype of Pc¹

(Strübbe et al., 2011)

ebi^E90 is a suppressor of mesothoracic leg phenotype of Pc¹

(Strübbe et al., 2011)

ebi^E90 is a suppressor of eye phenotype of Egfr::tor^{t4021E.hs.sev}

(Dong et al., 1999)

ebi^E90 is a suppressor of photoreceptor cell R7 phenotype of Egfr::tor^{t4021E.hs.sev}

(Dong et al., 1999)

NOT Suppressor of

Statement

Reference

ebi^E90 is a non-suppressor of eye phenotype of sev::tor^13D.hs.sev

(Dong et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for ebi^E90 enhances the small wing phenotype induced by Scer\GAL4^Bx-MS1096-mediated expression of Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}.

Heterozygosity for ebi^E90 enhances the small wing and wing vein loss phenotypes induced by Scer\GAL4^Bx-MS1096-mediated expression of aos^Scer\UAS.cMa.

Heterozygosity for ebi^E90 enhances the notched wing margin phenotype seen in sd^ETX4 hemizygous males.

(Marygold et al., 2011)

In sev⁶ hemizygotes that are also heterozygous for Sos^JC2, 14.7% of ommatidia contain R7 cells. This phenotype is dominantly enhanced by ebi^E90.

(Dong et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

ebi^E90 is rescued by ebi^+t7.5

(Marygold et al., 2011)

Comments

ebi^+t7.5 rescues the homozygous lethality of ebi^E90.

(Marygold et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

30720

ebi^E90/CyO, P{en1}wg^en11

Notes on Origin

Discoverer

Comments

Strong allele.

(Dong et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ebi E90

(Strübbe et al., 2011)

ebi⁹⁰

(Lim et al., 2012)

ebi^E90

(Sarov et al., 2016, Marygold et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (6)

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