FlyBase Allele Report: Dmel\Sos[JC2]

General Information

Symbol

Dmel\Sos^JC2

Species

D. melanogaster

Name

FlyBase ID

FBal0034023

Feature type

allele

Associated gene

Dmel\Sos

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

gain of function allele

Mutagen

Nature of the Allele

Allele class

gain of function allele

(Butler et al., 1997, Lim et al., 1997, Begemann et al., 1995, Greenwald and Rubin, 1992)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

photoreceptor cell R7

(Meisner et al., 1997, Sawamoto et al., 1996)

Detailed Description

Statement

Reference

Sos^JC2/+ mutants do not exhibit any discernible axon debris clearing defect.

Sos^JC2/+ mutants do not exhibit an increase in the total number of glial vesicles, nor an increase in the number of vesicles internalizing degenerating axons.

(Lu et al., 2014)

Partially rescues the sev⁶ R7 photoreceptor phenotype.

(Butler et al., 1997)

Heterozygotes and homozygotes have the normal number of 1 R7 cell per ommatidium.

(Lim et al., 1997)

In sev⁶; Sos^JC2 double heterozygotes an R7 cell develops in only 17% of the ommatidia. Raising the level of Cbl using Cbl^hs.2sev essentially eliminates development of R7 cells.

(Meisner et al., 1997)

Some homozygous ommatidia exhibit supernumerary R7 cells. Sos^JC2; argos¹⁵² flies exhibit extra R7-like cells in 25% of ommatidia.

(Sawamoto et al., 1996)

Suppresses the loss of R7 cells caused by sev⁶. In sev⁶/Y;Sos^JC2/+, 17% of ommatidia have R7 cells.

(Karlovich et al., 1995)

sev⁶/Sos^JC2 is a sensitive genetic background that can be used to analyse the effect on R7 development of aop alleles. In this flies only 16% of R7 cells in the ommatidia develop. Removal of one copy of aop causes an increase in the number of R7 cells.

(Rogge et al., 1995)

R7 cells develop in only 17% of sev⁶/sev⁶; Sos^JC2/Sos⁺ ommatidia. Loss of one wild type copy of boss or Ras85D reduces the suppression to 0%. Loss of a single copy of Gap1 causes R7 cells to develop in half the ommatidia.

(Rogge et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Dsor1^Su1, Sos^JC2 has visible phenotype, enhanceable by cln[+]/cln^SF3-2

(Taguchi et al., 2000)

Other

Statement

Reference

Dsor1^Su1, Sos^JC2 has visible phenotype

(Taguchi et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, enhanceable by rin¹/rin[+]

(Pazman et al., 2000)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, enhanceable by rin²/rin[+]

(Pazman et al., 2000)

Dsor1^Su1, Sos^JC2 has wing vein | ectopic phenotype, enhanceable by cln[+]/cln^SF3-2

(Taguchi et al., 2000)

Dsor1^Su1, Sos^JC2 has wing phenotype, enhanceable by cln[+]/cln^SF3-2

(Taguchi et al., 2000)

Sos^JC2, sev⁶ has ommatidium phenotype, enhanceable by cnk^sag13L

(Zhang and Lu, 2000)

Sos^JC2/Sos[+], sev⁶ has ommatidium phenotype, enhanceable by Egfr[+]/Egfr^f2

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has photoreceptor cell R7 phenotype, enhanceable by Egfr[+]/Egfr^f2

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has ommatidium phenotype, enhanceable by ebi[+]/ebi^E4

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has photoreceptor cell R7 phenotype, enhanceable by ebi[+]/ebi^E4

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has ommatidium phenotype, enhanceable by ebi^E90/ebi[+]

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has photoreceptor cell R7 phenotype, enhanceable by ebi^E90/ebi[+]

(Dong et al., 1999)

Sos^JC2, sev⁶ has ommatidium phenotype, enhanceable by Egfr[+]/Egfr^f2

(Dong et al., 1999)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, enhanceable by Egfr[+]/Egfr^f2

(Dong et al., 1999)

Sos^JC2, sev⁶ has ommatidium phenotype, enhanceable by ebi[+]/ebi^E4

(Dong et al., 1999)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, enhanceable by ebi[+]/ebi^E4

(Dong et al., 1999)

Sos^JC2, sev⁶ has ommatidium phenotype, enhanceable by ebi^E90/ebi[+]

(Dong et al., 1999)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, enhanceable by ebi^E90/ebi[+]

(Dong et al., 1999)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, enhanceable by ast[+]/ast¹

(Kolodkin et al., 1994)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, enhanceable by ast⁴/ast[+]

(Kolodkin et al., 1994)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, enhanceable by S[+]/S^104E

(Kolodkin et al., 1994)

Suppressed by

Statement

Reference

Sos^JC2/Sos[+], sev⁶ has ommatidium phenotype, suppressible | partially by ttk[+]/ttk¹

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has photoreceptor cell R7 phenotype, suppressible | partially by ttk[+]/ttk¹

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has ommatidium phenotype, suppressible | partially by ttk[+]/ttk⁰⁰²¹⁹

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has photoreceptor cell R7 phenotype, suppressible | partially by ttk[+]/ttk⁰⁰²¹⁹

(Dong et al., 1999)

Sos^JC2, sev⁶ has ommatidium phenotype, suppressible | partially by ttk[+]/ttk¹

(Dong et al., 1999)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible | partially by ttk[+]/ttk¹

(Dong et al., 1999)

Sos^JC2, sev⁶ has ommatidium phenotype, suppressible | partially by ttk[+]/ttk⁰⁰²¹⁹

(Dong et al., 1999)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible | partially by ttk[+]/ttk⁰⁰²¹⁹

(Dong et al., 1999)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by aop^A141

(Rogge et al., 1995)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by aop^e2d

(Rogge et al., 1995)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by aop^pok-x8

(Rogge et al., 1995)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by aop^yan-1

(Rogge et al., 1995)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by aop¹

(Rogge et al., 1995)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by aop²

(Rogge et al., 1995)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by S^hs.7

(Kolodkin et al., 1994)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by S^hs.8

(Kolodkin et al., 1994)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by S^hs.sev

(Kolodkin et al., 1994)

Sos^JC2 has photoreceptor cell R7 phenotype, suppressible by sev⁶

(Kolodkin et al., 1994)

Enhancer of

Statement

Reference

Sos^JC2 is an enhancer of photoreceptor cell R2 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Sos^JC2 is an enhancer of photoreceptor cell R3 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Sos^JC2 is an enhancer of photoreceptor cell R4 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Sos^JC2 is an enhancer of photoreceptor cell R5 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Sos^JC2 is an enhancer of photoreceptor cell R6 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Sos^JC2 is an enhancer of photoreceptor cell R1 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Sos^JC2 is an enhancer of phenotype of svp^1.sev

(Begemann et al., 1995)

Sos^JC2 is an enhancer of phenotype of svp^2.sev

(Begemann et al., 1995)

Suppressor of

Statement

Reference

Sos^JC2/Sos[+] is a suppressor | partially of glial cell phenotype of Rac1^N17.UAS, Scer\GAL4^repo, Scer\GAL80^ts.αTub84B

(Lu et al., 2014)

Sos^JC2/Sos[+] is a suppressor | partially of vesicle phenotype of Rac1^N17.UAS, Scer\GAL4^repo, Scer\GAL80^ts.αTub84B

(Lu et al., 2014)

Sos^JC2/Sos[+] is a suppressor of vesicle phenotype of Scer\GAL4^repo, Scer\GAL80^ts.αTub84B, drk^KK109233

(Lu et al., 2014)

Sos^JC2/Sos[+] is a suppressor of glial cell phenotype of Scer\GAL4^drl.442, drk^KK109233

(Lu et al., 2014)

Sos^JC2/Sos[+] is a suppressor of glial cell phenotype of Ced-12^GD4186, Scer\GAL4^repo, Scer\GAL80^ts.αTub84B

(Lu et al., 2014)

Sos^JC2/Sos[+] is a suppressor of vesicle phenotype of Ced-12^GD4186, Scer\GAL4^repo, Scer\GAL80^ts.αTub84B

(Lu et al., 2014)

Sos^JC2 is a suppressor of larval longitudinal connective phenotype of Khc::Ggal\MLCK^KA.ftz

(Fritz and VanBerkum, 2000)

Sos^JC2 is a suppressor of larval longitudinal connective phenotype of robo1¹

(Fritz and VanBerkum, 2000)

Sos^JC2 is a suppressor | partially of larval longitudinal connective phenotype of Khc::Ggal\MLCK^KA.ftz, robo1¹

(Fritz and VanBerkum, 2000)

Sos^JC2 is a suppressor of phenotype of sev⁶

(Pazman et al., 2000, Bonfini et al., 1992)

Sos^JC2 is a suppressor of photoreceptor cell R7 phenotype of sev⁶

(Pazman et al., 2000, Kolodkin et al., 1994, Rogge et al., 1991)

Other

Statement

Reference

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype

(Zhang and Lu, 2000, Dong et al., 1999, Rogge et al., 1995, Biggs et al., 1994)

Sos^JC2, sev⁶ has ommatidium phenotype

(Zhang and Lu, 2000, Dong et al., 1999)

Dsor1^Su1, Sos^JC2 has wing phenotype

(Taguchi et al., 2000)

Dsor1^Su1, Sos^JC2 has wing vein | ectopic phenotype

(Taguchi et al., 2000)

Sos^JC2/Sos[+], sev⁶ has ommatidium phenotype

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has photoreceptor cell R7 phenotype

(Dong et al., 1999)

B-H1^sev.PH, Sos^JC2 has photoreceptor cell R7 | ectopic phenotype

(Hayashi et al., 1998)

Sos^JC2, klg^E1432, sev⁶ has ommatidium phenotype

(Butler et al., 1997)

Sos^JC2, klg^E226, sev⁶ has ommatidium phenotype

(Butler et al., 1997)

Sos^JC2, klg^H214, sev⁶ has ommatidium phenotype

(Butler et al., 1997)

Dsor1^Su4, Sos^JC2 has ommatidium phenotype

(Lim et al., 1997)

Dsor1^Su4, Sos^JC2 has photoreceptor cell R7 phenotype

(Lim et al., 1997)

Dsor1^Su7, Sos^JC2 has ommatidium phenotype

(Lim et al., 1997)

Dsor1^Su7, Sos^JC2 has photoreceptor cell R7 phenotype

(Lim et al., 1997)

Dsor1^Su1, Sos^JC2 has ommatidium phenotype

(Lim et al., 1997)

Dsor1^Su1, Sos^JC2 has photoreceptor cell R7 phenotype

(Lim et al., 1997)

Dsor1^Su18, Sos^JC2 has ommatidium phenotype

(Lim et al., 1997)

Dsor1^Su18, Sos^JC2 has photoreceptor cell R7 phenotype

(Lim et al., 1997)

Dsor1^Su24, Sos^JC2 has ommatidium phenotype

(Lim et al., 1997)

Dsor1^Su24, Sos^JC2 has photoreceptor cell R7 phenotype

(Lim et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

A Sos^JC2/+ background suppresses the delay in axonal debris clearance after axotomy found upon knockdown of either drk or dos (through expression of drk^KK109233 or dos^{Scer\UAS.dsRNA} under the control of Scer\GAL4^repo and Scer\GAL80^ts.αTub84B).

A Sos^JC2/+ background is sufficient to suppress the loss of glial membrane vesicles in drk knockdown flies. In addition, the internalization of axonal debris into these vesicles rises to wild-type levels in a Sos^JC2/+ background.

Expression of Rac1^N17.Scer\UAS specifically in adult glia (under the control of Scer\GAL4^repo and Scer\GAL80^ts.αTub84B) in a Sos^JC2/+ background, results in a 50% suppression of axon debris clearance, compared to wild-type.

(Lu et al., 2014)

18.7% of ommatidia have an R7 cell in sev⁶; Sos^JC2 flies. This partial rescue of sev⁶ by Sos^JC2 is relieved by rin¹ or rin²; 13.9% and 18.2% of ommatidia have an R7 cell in sev⁶ ; Sos^JC2/+ ; rin¹/+ and sev⁶; Sos^JC2/+ ; rin²/+ flies respectively.

28.7% of ommatidia have an R7 cell in sev⁶ ; Sos^JC2 flies. This partial rescue of sev⁶ by Sos^JC2 is relieved by rin¹ or rin²; 13.9% and 18.2% of ommatidia have an R7 cell in sev⁶ ; Sos^JC2/+ ; rin¹/+ and sev⁶ ; Sos^JC2/+ ; rin²/+ flies respectively.

(Pazman et al., 2000)

Dsor1^Su1/Y ; Sos^JC2/+ flies have extra wing veins. This phenotype is enhanced by one copy of cln^SF3-2.

(Taguchi et al., 2000)

In sev⁶/Y;Sos^JC2/+ flies. all outer photoreceptor cells form normally whereas the R7 cells form in only 21% of the ommatidia. The addition of sag^13L enhances this phenotype so that R7 cells form in only 0.7% of ommatidia.

(Zhang and Lu, 2000)

In sev⁶ hemizygotes that are also heterozygous for Sos^JC2, 14.7% of ommatidia contain R7 cells. This phenotype is dominantly enhanced by Egfr^f2, ebi^E4 and ebi^E90, and dominantly suppressed by ttk¹ and ttk⁰⁰²¹⁹.

(Dong et al., 1999)

Significantly enhances the formation of extra outer photoreceptors caused by B-H1^sev.PH. Sos^JC2 flies carrying B-H1^sev.PH have a considerable number of extra R7-like cells.

(Hayashi et al., 1998)

Sos^JC2 heterozygotes also hemizygous for Dsor1^Su1 have 2.62 +/- 0.83 R7-like cells per ommatidium. Sos^JC2 heterozygotes also hemizygous for Dsor1^Su4 have 3.01 +/- 0.72 R7-like cells per ommatidium. Sos^JC2 heterozygotes also hemizygous for Dsor1^Su7 have 2.76 +/- 1.07 R7-like cells per ommatidium. Sos^JC2 heterozygotes also hemizygous for Dsor1^Su18 have 1.54 +/- 0.71 R7-like cells per ommatidium. Sos^JC2 heterozygotes also hemizygous for Dsor1^Su24 have 3.02 +/- 1.05 R7-like cells per ommatidium.

(Lim et al., 1997)

Enhancer of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

(Begemann et al., 1995)

Some ommatidia of male heterozygotes with sev⁶ contain R7 cells, this rough eye phenotype can be rescued by the rl^hs.PB construct.

(Biggs et al., 1994)

Partially suppresses the R7 phenotype of sev⁶ : Double mutants have R7 cells in 16% of ommatidia, in contrast to 0% in sev⁶ alone. This suppression is almost entirely reversed if the flies are also made hetozygous for ast¹ or ast⁴.

(Kolodkin et al., 1994)

Partly suppresses the sev⁶ phenotype; sev⁶ flies carrying one copy of Sos^JC2 have R7 cells in 16% of their ommatidia. Flies doubly homozygous for sev⁶ and boss¹ and also heterozygous for Sos^JC2 have no R7 photoreceptor cells. Flies homozygous for sev⁶, heterozygous for Sos^JC2 and heterozygous for either Df(3R)by62 or Df(3R)by10 have no R7 photoreceptor cells.

(Bonfini et al., 1992)

Dominant suppression of the sev⁶ phenotype, a fraction of the ommatidia contain R7 cells. Suppression is repressed by one copy of boss¹. When in combination with other sev alleles no R7 cell is seen, mutant phenotype is not suppressed.

(Rogge et al., 1991)

Xenogenetic Interactions

Statement

Reference

Sos^JC2 suppresses the axon crossing over phenotype seen in embryos carrying Khc::Ggal\MLCK^KA.ftz and in robo¹ heterozygotes. Partially suppresses the interaction between robo¹ and Khc::Ggal\MLCK^KA.ftz.

(Fritz and VanBerkum, 2000)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Mosaic analysis demonstrates that the Sos^JC2 mutant function is autonomously required in the R7 cell for the suppression of the sev phenotype. Suppression of the sev⁶ mutant phenotype is higher than provided by the wild type Sos gene product and loss of function Sos alleles.

(Rogge et al., 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

SOS^jc2

(Williams et al., 2001)

Sos^J2

(Greenwald and Rubin, 1992, Rubin, 1991)

Sos^JC2

(Lu et al., 2014, Pazman et al., 2000, Biggs et al., 1994)

sos^JC2

(Kockel et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (28)

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