FlyBase Allele Report: Dmel\aop[1]

General Information

Symbol

Dmel\aop¹

Species

D. melanogaster

Name

FlyBase ID

FBal0000622

Feature type

allele

Associated gene

Dmel\aop

Associated Insertion(s)

Carried in Construct

Also Known As

aop^IP

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Rogge et al., 1995)

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G952A.

(Caviglia and Luschnig, 2013)

Amino acid replacement: Q318term.

(Caviglia and Luschnig, 2013)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:2,159,540..2,159,540 [-]

Nucleotide change:

C2159540T

Reported nucleotide change:

G952A

Amino acid change:

Reported amino acid change:

Q318term

Comment:

The nucleotide change was reported as G952A, presumably relative to the noncoding strand. The nucleotide change required for the nonsense mutation is C952T (nucleotide position relative to the aop CDS).

(Caviglia and Luschnig, 2013)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Yamada et al., 2003)

decreased cell number | embryonic stage (with Df(2L)Exel6006)

(Schwarz et al., 2018)

lethal - all die during embryonic stage

(Ríos-Barrera et al., 2015)

lethal - all die during embryonic stage | recessive

partially lethal - majority die (with aop^pok-x8)

(Rogge et al., 1995)

some die during embryonic stage | recessive

Phenotype Manifest In

abdominal lateral pentascolopidial chordotonal organ lch5

(Yamada et al., 2003)

border follicle cell | somatic clone

(Borghese et al., 2006)

chordotonal organ

(Okabe and Okano, 1997)

embryonic/first instar larval cuticle | dorsal

(Riesgo-Escovar and Hafen, 1997)

embryonic/larval cuticle

(Ríos-Barrera et al., 2015)

embryonic/larval pericardial cell

(Halfon et al., 2000)

embryonic cardioblast (with Df(2L)Exel6006)

(Schwarz et al., 2018)

embryonic ostial cardioblast (with Df(2L)Exel6006)

(Schwarz et al., 2018)

follicle cell | somatic clone

(Borghese et al., 2006)

heart primordium (with Df(2L)Exel6006)

(Schwarz et al., 2018)

mesoderm

(Halfon et al., 2000)

muscle cell of A1-7 dorsal acute muscle 1

(Halfon et al., 2000)

ommatidium (with aop^pok-x8)

(Rogge et al., 1995)

photoreceptor cell R7 | ectopic (with aop^pok-x8)

(Rogge et al., 1995)

pigment cell (with aop^pok-x8)

(Rogge et al., 1995)

Detailed Description

Statement

Reference

aop¹/Df(2L)Exel6006 mutant embryos present significant decreases in the number of cardioblasts (both generic cardioblasts and ostial cardioblasts), as compared to controls.

(Schwarz et al., 2018)

aop¹ heterozygotes do not show a tumor-like testis phenotype.

(Feng et al., 2017)

aop¹ mutant embryos display anterior holes in the cuticle and fault dorsal closure.

(Ríos-Barrera et al., 2015)

Homozygous border cell clones show defects in migration. The clones are rarely recovered and defects are seen in other follicle cells and in germline cells.

(Borghese et al., 2006)

Homozygous embryos show an increase in the number of scolopidia in the lch5 chordotonal organs.

(Yamada et al., 2003)

Mutant embryos have an increased number of eve-expressing progenitors and their derivatives (eve-expressing pericardial cells and muscle DA1) in the mesoderm.

(Halfon et al., 2000)

Embryos have 1 or 2 additional chordotonal organs per abdominal hemisegment compared to wild-type.

(Okabe and Okano, 1997)

Embryonic dorsal cuticle lacks dorsal hairs and has a convoluted appearance. Examination of the lateral epithelium reveals the cells to stretch but they are disorganised and variable in size.

(Riesgo-Escovar and Hafen, 1997)

Transheterozygote aop¹/aop^pok-x8 adult escapers have small rough eyes.

(Rogge et al., 1995)

Homozygous embryos have anterior dorsal hole in epidermis. Brain and sometimes gut extrude through hole. Head involution normal. Visible during dorsal closure.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

aop¹/Df(2L)Exel6006 has decreased cell number | embryonic stage phenotype, enhanceable by edl^k06602

(Schwarz et al., 2018)

Suppressed by

Statement

Reference

aop¹ has lethal - all die during embryonic stage phenotype, suppressible by acal[+]/lncRNA:acal⁵

(Ríos-Barrera et al., 2015)

Enhancer of

Statement

Reference

aop¹/Df(2L)Exel6006 is an enhancer of decreased cell number | embryonic stage phenotype of edl^k06602

(Schwarz et al., 2018)

NOT Enhancer of

Statement

Reference

aop[+]/aop¹ is a non-enhancer of visible phenotype of CycE^JP

(Brumby et al., 2004)

aop¹ is a non-enhancer of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

aop¹ is a non-enhancer of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

aop¹ is a non-enhancer of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Suppressor of

Statement

Reference

aop[+]/aop¹ is a suppressor | partially of neoplasia | spermatogenesis phenotype of E(Pc)^JF03101, Scer\GAL4^NP1624

(Feng et al., 2017)

aop¹ is a suppressor | partially of lethal phenotype of lncRNA:acal⁵

(Ríos-Barrera et al., 2015)

aop¹ is a suppressor | partially of some die during embryonic stage phenotype of lncRNA:acal⁵

(Ríos-Barrera et al., 2015)

aop[+]/aop¹ is a suppressor | partially of partially lethal - majority die phenotype of slpr^BS06

(Polaski et al., 2006)

aop¹ is a suppressor of visible phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

aop[+]/aop¹ is a suppressor of visible | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

aop[+]/aop¹ is a suppressor of visible | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

NOT Suppressor of

Statement

Reference

aop[+]/aop¹ is a non-suppressor of visible phenotype of CycE^JP

(Brumby et al., 2004)

aop¹ is a non-suppressor of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

aop¹ is a non-suppressor of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

aop¹ is a non-suppressor of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Other

Statement

Reference

aop¹, acal[+]/lncRNA:acal⁵ has some die during embryonic stage phenotype

(Ríos-Barrera et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

aop¹/Df(2L)Exel6006 has embryonic cardioblast phenotype, enhanceable by edl^k06602

(Schwarz et al., 2018)

aop¹/Df(2L)Exel6006 has embryonic ostial cardioblast phenotype, enhanceable by edl^k06602

(Schwarz et al., 2018)

aop¹ has heart primordium phenotype, enhanceable by edl^k06602

(Schwarz et al., 2018)

Suppressed by

Statement

Reference

aop¹ has embryonic/larval cuticle phenotype, suppressible by acal[+]/lncRNA:acal⁵

(Ríos-Barrera et al., 2015)

Enhancer of

Statement

Reference

aop¹/Df(2L)Exel6006 is an enhancer of embryonic cardioblast phenotype of edl^k06602

(Schwarz et al., 2018)

aop¹/Df(2L)Exel6006 is an enhancer of embryonic ostial cardioblast phenotype of edl^k06602

(Schwarz et al., 2018)

aop¹/Df(2L)Exel6006 is an enhancer of heart primordium phenotype of edl^k06602

(Schwarz et al., 2018)

aop[+]/aop¹ is an enhancer of male germline stem cell | increased number phenotype of E(Pc)^GL00169, Scer\GAL4^NP1624

(Feng et al., 2017)

aop[+]/aop¹ is an enhancer of ommatidium phenotype of Egfr^E1

(Rogge et al., 1995)

NOT Enhancer of

Statement

Reference

aop[+]/aop¹ is a non-enhancer of eye phenotype of CycE^JP

(Brumby et al., 2004)

aop¹ is a non-enhancer of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

aop¹ is a non-enhancer of ommatidium phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

aop¹ is a non-enhancer of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

aop¹ is a non-enhancer of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

aop¹ is a non-enhancer of phenotype of Rho1^rev220

(Magie et al., 1999)

Suppressor of

Statement

Reference

aop¹ is a suppressor | partially of embryonic/larval cuticle phenotype of lncRNA:acal⁵

(Ríos-Barrera et al., 2015)

aop[+]/aop¹ is a suppressor of eye phenotype of H^UAS.cMa, Scer\GAL4^GMR.PU

(Protzer et al., 2008)

aop¹ is a suppressor of eye phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

aop[+]/aop¹ is a suppressor of eye | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

aop[+]/aop¹ is a suppressor of wing vein | ectopic | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

aop[+]/aop¹ is a suppressor of wing | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

aop¹ is a suppressor of photoreceptor cell R7 phenotype of Sos^JC2, sev⁶

(Rogge et al., 1995)

NOT Suppressor of

Statement

Reference

aop[+]/aop¹ is a non-suppressor of eye phenotype of CycE^JP

(Brumby et al., 2004)

aop¹ is a non-suppressor of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

aop¹ is a non-suppressor of ommatidium phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

aop¹ is a non-suppressor of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

aop¹ is a non-suppressor of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

aop¹ is a non-suppressor of phenotype of Rho1^rev220

(Magie et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The decreased number of cardioblasts observed in aop¹/Df(2L)Exel6006 and edl^k06602 single mutant embryos is slightly more severe in the double mutants.

(Schwarz et al., 2018)

One copy of acal⁵ almost completely rescues the dorsal closure defects and lethality seen in aop¹ mutant embryos.

One copy of aop¹ does not rescue the dorsal closure defects and lethality seen in acal⁵ mutant embryos.

(Ríos-Barrera et al., 2015)

The small-eye phenotype observed in animals expressing H^Scer\UAS.cMa in the eye under the control of Scer\GAL4^GMR.PU is partially suppressed in a aop¹/+ mutant background.

(Protzer et al., 2008)

Introduction of Df(2R)edl-L19 into an aop¹ background causes a clear reduction in the number of scolopidia formed in the lch5 chordotonal organs.

(Yamada et al., 2003)

sev⁶/sev⁺; Sos^JC2/aop¹ exhibit an increase in the number of R7 cells compared to sev⁶/Sos^JC2 mutants with two functional aop copies.

(Rogge et al., 1995)

Xenogenetic Interactions

Statement

Reference

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is not modified if the flies are also carrying aop¹.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Partially complements

aop^pok-x8

(Rogge et al., 1995)

Fails to complement

aop^e2d

(Rogge et al., 1995)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

3101

aop¹ cn¹ bw¹ speck¹/CyO

Kyoto

106842

aop¹ cn¹ bw¹ speck¹/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

(Arora et al., 1995)

Yan^P

(Boulton et al., 2000)

aop-Ip

(Rogge et al., 1995)

aop¹

(Zhou et al., 2019, Schwarz et al., 2018, Sarov et al., 2016, Ríos-Barrera et al., 2015, Caviglia and Luschnig, 2013, Weng et al., 2012, Hwang and Rulifson, 2011, Salzer et al., 2010, Protzer et al., 2008, Borghese et al., 2006, Polaski et al., 2006)

aop^I5

(Gabay et al., 1996)

aop^IP

(Smith et al., 2002, Magie et al., 1999, O'Keefe et al., 1997, Tearle and Nusslein-Volhard, 1987)

yan^IP

(Feng et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (35)

Report Sections

Open Close