FlyBase Allele Report: Dmel\sev[6]

General Information

Symbol

Dmel\sev⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0015450

Feature type

allele

Associated gene

Dmel\sev

Associated Insertion(s)

Carried in Construct

Also Known As

sev^E4

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Butler et al., 1997, Biggs et al., 1994)

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | recessive

(Ruden et al., 1999)

Phenotype Manifest In

ommatidium

(Butler et al., 1997)

photoreceptor cell R7

(Pazman et al., 2000, Ruden et al., 1999, Lim et al., 1997, Meisner et al., 1997, Karlovich et al., 1995, Kolodkin et al., 1994, Bonfini et al., 1992, Rogge et al., 1992)

photoreceptor neuron

(Biggs et al., 1994)

Detailed Description

Statement

Reference

The R7 photoreceptors fail to develop in homozygous sev⁶ flies.

(Ruden et al., 1999)

R7 photoreceptor cells are absent in hemizygotes. Hemizygotes carrying one copy of Sos^JC2 have R7 cells in 18.5% of their ommatidia. The proportion of ommatidia containing an R7 cell is reduced if the flies also carry one copy of klg^H214, klg^E226, klg^E1432 or Df(3R)hh.

(Butler et al., 1997)

Hemizygous flies lack R7 photoreceptor cells in the ommatidia.

(Lim et al., 1997)

In sev⁶; Sos^JC2 double heterozygotes an R7 cell develops in only 17% of the ommatidia. Raising the level of Cbl using Cbl^hs.2sev essentially eliminates development of R7 cells.

(Meisner et al., 1997)

No R7 cells develop. In sev⁶/Y;Sos^JC2/+, 17% of ommatidia have R7 cells. 30% of sev⁶/Y;Sos^NCatC.hs.sev ommatidia have R7 cells, 23% of sev⁶/Y;Sos^NCat.hs.sev ommatidia have R7 cells.

(Karlovich et al., 1995)

sev⁶/Sos^JC2 is a sensitive genetic background that can be used to analyse the effect on R7 development of aop alleles. In this flies only 16% of R7 cells in the ommatidia develop. Removal of one copy of aop causes an increase in the number of R7 cells.

(Rogge et al., 1995)

Homozygous flies have no R7 photoreceptor cells.

(Bonfini et al., 1992)

Homozygous ommatidia lack photoreceptor cell R7. Ommatidia of double mutants with Gap1^sxt-BJ61 display extra R7 cells. R7 cells develop in only 17% of sev⁶/sev⁶; Sos^JC2/Sos⁺ ommatidia. Loss of one wild type copy of boss or Ras85D reduces the suppression to 0%. Loss of a single copy of Gap1 causes R7 cells to develop in half the ommatidia.

(Rogge et al., 1992)

positive phototaxis with Ppb/+

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

sev⁶ has visible | recessive phenotype, suppressible by S^Kojak

(Ruden et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, enhanceable by rin²/rin[+]

(Pazman et al., 2000)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, enhanceable by rin¹/rin[+]

(Pazman et al., 2000)

Sos^JC2, sev⁶ has ommatidium phenotype, enhanceable by cnk^sag13L

(Zhang and Lu, 2000)

Sos^JC2/Sos[+], sev⁶ has ommatidium phenotype, enhanceable by Egfr[+]/Egfr^f2

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has photoreceptor cell R7 phenotype, enhanceable by Egfr[+]/Egfr^f2

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has ommatidium phenotype, enhanceable by ebi[+]/ebi^E4

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has photoreceptor cell R7 phenotype, enhanceable by ebi[+]/ebi^E4

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has ommatidium phenotype, enhanceable by ebi^E90/ebi[+]

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has photoreceptor cell R7 phenotype, enhanceable by ebi^E90/ebi[+]

(Dong et al., 1999)

Sos^JC2, sev⁶ has ommatidium phenotype, enhanceable by Egfr[+]/Egfr^f2

(Dong et al., 1999)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, enhanceable by Egfr[+]/Egfr^f2

(Dong et al., 1999)

Sos^JC2, sev⁶ has ommatidium phenotype, enhanceable by ebi[+]/ebi^E4

(Dong et al., 1999)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, enhanceable by ebi[+]/ebi^E4

(Dong et al., 1999)

Sos^JC2, sev⁶ has ommatidium phenotype, enhanceable by ebi^E90/ebi[+]

(Dong et al., 1999)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, enhanceable by ebi^E90/ebi[+]

(Dong et al., 1999)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, enhanceable by ast[+]/ast¹

(Kolodkin et al., 1994)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, enhanceable by ast⁴/ast[+]

(Kolodkin et al., 1994)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, enhanceable by S[+]/S^104E

(Kolodkin et al., 1994)

Suppressed by

Statement

Reference

sev⁶ has photoreceptor cell R7 phenotype, suppressible by Sos^JC2

(Pazman et al., 2000, Kolodkin et al., 1994, Rogge et al., 1991)

sev⁶ has phenotype, suppressible by Sos^JC2

(Pazman et al., 2000, Bonfini et al., 1992)

Sos^JC2/Sos[+], sev⁶ has ommatidium phenotype, suppressible | partially by ttk[+]/ttk¹

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has photoreceptor cell R7 phenotype, suppressible | partially by ttk[+]/ttk¹

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has ommatidium phenotype, suppressible | partially by ttk[+]/ttk⁰⁰²¹⁹

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has photoreceptor cell R7 phenotype, suppressible | partially by ttk[+]/ttk⁰⁰²¹⁹

(Dong et al., 1999)

Sos^JC2, sev⁶ has ommatidium phenotype, suppressible | partially by ttk[+]/ttk¹

(Dong et al., 1999)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible | partially by ttk[+]/ttk¹

(Dong et al., 1999)

Sos^JC2, sev⁶ has ommatidium phenotype, suppressible | partially by ttk[+]/ttk⁰⁰²¹⁹

(Dong et al., 1999)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible | partially by ttk[+]/ttk⁰⁰²¹⁹

(Dong et al., 1999)

sev⁶ has photoreceptor cell R7 phenotype, suppressible by S^Kojak

(Ruden et al., 1999)

sev⁶ has phenotype, suppressible by Dsor1^Su12

(Lim et al., 1997)

sev⁶ has phenotype, suppressible by Dsor1^Su18

(Lim et al., 1997)

sev⁶ has phenotype, suppressible by Dsor1^Su1

(Lim et al., 1997)

sev⁶ has phenotype, suppressible by Dsor1^Su24

(Lim et al., 1997)

sev⁶ has phenotype, suppressible by Dsor1^Su4

(Lim et al., 1997)

sev⁶ has phenotype, suppressible by Dsor1^Su6

(Lim et al., 1997)

sev⁶ has phenotype, suppressible by Dsor1^Su7

(Lim et al., 1997)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by aop^e2d

(Rogge et al., 1995)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by aop^pok-x8

(Rogge et al., 1995)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by aop^yan-1

(Rogge et al., 1995)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by aop¹

(Rogge et al., 1995)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by aop²

(Rogge et al., 1995)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by aop^A141

(Rogge et al., 1995)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by S^hs.7

(Kolodkin et al., 1994)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by S^hs.8

(Kolodkin et al., 1994)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype, suppressible by S^hs.sev

(Kolodkin et al., 1994)

Suppressor of

Statement

Reference

sev⁶ is a suppressor of photoreceptor cell R7 phenotype of Sos^JC2

(Kolodkin et al., 1994)

Other

Statement

Reference

Sos^JC2, sev⁶ has ommatidium phenotype

(Zhang and Lu, 2000, Dong et al., 1999)

Sos^JC2, sev⁶ has photoreceptor cell R7 phenotype

(Zhang and Lu, 2000, Dong et al., 1999, Rogge et al., 1995, Biggs et al., 1994)

Sos^JC2/Sos[+], sev⁶ has ommatidium phenotype

(Dong et al., 1999)

Sos^JC2/Sos[+], sev⁶ has photoreceptor cell R7 phenotype

(Dong et al., 1999)

Sos^JC2, klg^H214, sev⁶ has ommatidium phenotype

(Butler et al., 1997)

Sos^JC2, klg^E1432, sev⁶ has ommatidium phenotype

(Butler et al., 1997)

Sos^JC2, klg^E226, sev⁶ has ommatidium phenotype

(Butler et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

18.7% of ommatidia have an R7 cell in sev⁶; Sos^JC2 flies. This partial rescue of sev⁶ by Sos^JC2 is relieved by rin¹ or rin²; 13.9% and 18.2% of ommatidia have an R7 cell in sev⁶ ; Sos^JC2/+ ; rin¹/+ and sev⁶; Sos^JC2/+ ; rin²/+ flies respectively.

28.7% of ommatidia have an R7 cell in sev⁶ ; Sos^JC2 flies. This partial rescue of sev⁶ by Sos^JC2 is relieved by rin¹ or rin²; 13.9% and 18.2% of ommatidia have an R7 cell in sev⁶ ; Sos^JC2/+ ; rin¹/+ and sev⁶ ; Sos^JC2/+ ; rin²/+ flies respectively.

(Pazman et al., 2000)

In sev⁶/Y;Sos^JC2/+ flies. all outer photoreceptor cells form normally whereas the R7 cells form in only 21% of the ommatidia. The addition of sag^13L enhances this phenotype so that R7 cells form in only 0.7% of ommatidia.

(Zhang and Lu, 2000)

In sev⁶ hemizygotes that are also heterozygous for Sos^JC2, 14.7% of ommatidia contain R7 cells. This phenotype is dominantly enhanced by Egfr^f2, ebi^E4 and ebi^E90, and dominantly suppressed by ttk¹ and ttk⁰⁰²¹⁹.

(Dong et al., 1999)

The sev⁶ phenotype is partly suppressed by S^Kojak; sev⁶/sev⁶ ; S^Kojak/+ flies have an R7 cell in approximately 50% of the ommatidia.

(Ruden et al., 1999)

The lack of R7 photoreceptor cells seen in sev⁶ hemizygotes is partly suppressed by Dsor1^Su1, Dsor1^Su4, Dsor1^Su6, Dsor1^Su7, Dsor1^Su12, Dsor1^Su18 and Dsor1^Su24.

(Lim et al., 1997)

Some ommatidia of male hemizygotes or heterozygotes with Sos^JC2 contain R7 cells, this rough eye phenotype can be rescued by the rl^hs.PB construct. Removing one copy of rl enhances this phenotype but is suppressed by increase in copy number of other members of the sev signalling pathway.

(Biggs et al., 1994)

Partially suppressed the R7 phenotype of Sos^JC2 : Double mutants have R7 cells in 16% of ommatidia, in contrast to 0% in sev⁶ alone. This suppression is almost entirely reversed if the flies are also made hetozygous for ast¹ or ast⁴.

(Kolodkin et al., 1994)

The homozygous phenotype is partly suppressed by Sos^JC2; homozygous flies carrying one copy of Sos^JC2 have R7 cells in 16% of their ommatidia. Flies doubly homozygous for sev⁶ and boss¹ and also heterozygous for Sos^JC2 have no R7 photoreceptor cells. Flies homozygous for sev⁶, heterozygous for Sos^JC2 and heterozygous for either Df(3R)by62 or Df(3R)by10 have no R7 photoreceptor cells.

(Bonfini et al., 1992)

Dominant suppression of the sev⁶ phenotype when in combination with Sos^JC2, a fraction of the ommatidia contain R7 cells. This suppression is repressed by one copy of boss¹ due to loss of the boss-dependent ligand of the sev receptor. Wild type Sos gene product provides lower levels of suppression and loss of function Sos alleles even lower.

(Rogge et al., 1991)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Weak sev allele.

(Biggs et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sev⁶

sev^E4

(Pazman et al., 2000, Zhang and Lu, 2000, Dong et al., 1999, Ruden et al., 1999, Butler et al., 1997, Kockel et al., 1997, Lim et al., 1997, Meisner et al., 1997, Karlovich et al., 1995, Rogge et al., 1995, Biggs et al., 1994, Kolodkin et al., 1994, Yamamoto, 1993, Bonfini et al., 1992, Rogge et al., 1992, Rogge et al., 1991)

Name Synonyms

Secondary FlyBase IDs

References (17)

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