FlyBase Allele Report: Dmel\sty[S73]

General Information

Symbol

Dmel\sty^S73

Species

D. melanogaster

Name

FlyBase ID

FBal0096672

Feature type

allele

Associated gene

Dmel\sty

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Casci et al., 1999)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Casci et al., 1999)

visible | dominant

(Zettl et al., 2011)

visible | recessive

(Casci et al., 1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

sty^S73/+ flies show a mild extra wing vein phenotype in 6.4% of adult flies grown at 29[o]C.

(Zettl et al., 2011)

Homozygous clones in the adult abdomen do not show any consistent alterations of normal polarity.

(Lawrence et al., 2002)

Homozygous embryos have a tracheal phenotype. Homozygous clones in the eye result in ommatidia with an average of 10.6 photoreceptors per ommatidium. Most of the extra photoreceptors have small rhabdomeres and are positioned centrally, characteristic of the R7 or R8 class, although some of the extra photoreceptors are of the R1-R6 class. Most ommatidia in homozygous pupae have extra cone cells and extra primary pigment cells. sty^S73/sty^S88 animals occasionally survive to adulthood. These survivors have an excess of photoreceptor cells in the ommatidia. Transformation of some of the mystery cells to photoreceptors is seen in third larval instar eye imaginal discs. No excess R8 cells are seen (by staining with an anti-boss antibody) indicating that the extra photoreceptor cells are of the R7 type. sty^S73/sty^S88 adult survivors have extra wing vein material. Homozygous eggs are not recovered from females containing homozygous germ line clones, suggesting a requirement for sty function in the germline.

(Casci et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

sty^S73 has visible | dominant phenotype, enhanceable by aos[+]/aos^Δ7

(Zettl et al., 2011)

sty^S73 has visible | dominant phenotype, enhanceable by rho-5[+]/rho-5^KO1

(Zettl et al., 2011)

rho-5[+]/rho-5^KO1, sty^S73 has visible | dominant phenotype, enhanceable by aos[+]/aos^Δ7

(Zettl et al., 2011)

aos[+]/aos^Δ7, sty^S73 has visible | dominant phenotype, enhanceable by rho-5[+]/rho-5^KO1

(Zettl et al., 2011)

Enhancer of

Statement

Reference

sty[+]/sty^S73 is an enhancer of visible phenotype of spi^s.sev

(Casci et al., 1999)

sty[+]/sty^S73 is an enhancer of visible phenotype of rho^hs.sev

(Casci et al., 1999)

sty[+]/sty^S73 is an enhancer of visible phenotype of S^hs.sev

(Casci et al., 1999)

sty[+]/sty^S73 is an enhancer of visible phenotype of Egfr::tor^{t4021E.hs.sev}

(Casci et al., 1999)

sty[+]/sty^S73 is an enhancer of visible phenotype of Egfr^II.UAS, Scer\GAL4^GMR.PF

(Casci et al., 1999)

Suppressor of

Statement

Reference

sty[+]/sty^S73 is a suppressor of visible phenotype of Egfr^t1/Egfr^f11

(Casci et al., 1999)

sty[+]/sty^S73 is a suppressor of visible phenotype of aos^GMR.PC

(Casci et al., 1999)

sty[+]/sty^S73 is a suppressor of visible | recessive phenotype of spi^SCP1

(Casci et al., 1999)

Other

Statement

Reference

aos^Δ7, sty^S73 has visible | dominant phenotype

(Casci et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

sty^S73 has wing vein phenotype, enhanceable by aos[+]/aos^Δ7

(Zettl et al., 2011)

sty^S73 has wing vein phenotype, enhanceable by rho-5[+]/rho-5^KO1

(Zettl et al., 2011)

rho-5[+]/rho-5^KO1, sty^S73 has wing vein phenotype, enhanceable by aos[+]/aos^Δ7

(Zettl et al., 2011)

aos[+]/aos^Δ7, sty^S73 has wing vein phenotype, enhanceable by rho-5[+]/rho-5^KO1

(Zettl et al., 2011)

Enhancer of

Statement

Reference

sty[+]/sty^S73 is an enhancer of adult optic lobe | adult stage phenotype of vap²

(Botella et al., 2003)

sty[+]/sty^S73 is an enhancer of eye phenotype of spi^s.sev

(Casci et al., 1999)

sty[+]/sty^S73 is an enhancer of eye phenotype of Egfr^II.UAS, Scer\GAL4^GMR.PF

(Casci et al., 1999)

sty[+]/sty^S73 is an enhancer of eye phenotype of rho^hs.sev

(Casci et al., 1999)

sty[+]/sty^S73 is an enhancer of eye phenotype of S^hs.sev

(Casci et al., 1999)

sty[+]/sty^S73 is an enhancer of eye phenotype of Egfr::tor^{t4021E.hs.sev}

(Casci et al., 1999)

Suppressor of

Statement

Reference

sty[+]/sty^S73 is a suppressor of wing vein L4 phenotype of Egfr^t1/Egfr^f11

(Casci et al., 1999)

sty^S73 is a suppressor of embryo | posterior phenotype of tor³

(Casci et al., 1999)

sty^S73 is a suppressor of embryonic abdominal segment 8 phenotype of trk⁵

(Casci et al., 1999)

sty^S73 is a suppressor of embryo | posterior phenotype of trk⁵

(Casci et al., 1999)

sty[+]/sty^S73 is a suppressor of anterior crossvein phenotype of Egfr^t1/Egfr^f11

(Casci et al., 1999)

sty[+]/sty^S73 is a suppressor of eye phenotype of Egfr^t1/Egfr^f11

(Casci et al., 1999)

sty[+]/sty^S73 is a suppressor of eye phenotype of aos^GMR.PC

(Casci et al., 1999)

sty^S73 is a suppressor of photoreceptor cell R7 phenotype of sev¹⁴

(Casci et al., 1999)

sty[+]/sty^S73 is a suppressor of eye phenotype of spi^SCP1

(Casci et al., 1999)

sty^S73 is a suppressor of embryonic abdominal segment 8 phenotype of tor³

(Casci et al., 1999)

Other

Statement

Reference

aos^Δ7, sty^S73 has eye phenotype

(Casci et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of aos^Δ7 enhances the extra wing vein phenotype seen in sty^S73 heterozygotes at 29[o]C.

One copy of rho-5^KO1 enhances the extra wing vein phenotype seen in sty^S73 heterozygotes at 29[o]C.

One copy of aos^Δ7 enhances the extra vein phenotype seen in rho-5^KO1 sty^S73 double heterozygotes at 29[o]C.

One copy of rho-5^KO1 enhances the extra vein phenotype seen in aos^Δ7 sty^S73 double heterozygotes at 29[o]C.

(Zettl et al., 2011)

Dominantly suppresses the rough eye phenotype of flies expressing argos^GMR.PC. Dominantly suppresses the rough eye phenotype of spi^SCP1 homozygotes. Dominantly suppresses the rough eye and wing vein phenotypes of Egfr^t1/Egfr^f11 flies. Dominantly enhances the rough eye phenotype of flies expressing rho^hs.sev. Weakly dominantly enhances the eye phenotype of flies expressing spi^s.sev or S^hs.sev. Weakly dominantly enhances the eye phenotype of flies expressing Egfr^II.Scer\UAS under the control of Scer\GAL4^GMR.PF. sty^S73/argos^Δ7 double heterozygotes have a mild rough eye phenotype. Homozygous sev¹⁴ ommatidia have no R7 photoreceptors. R7 cells do form in sev¹⁴; sty^S73 double mutant ommatidia. In mosaic ommatidia, the only cell that needs to be mutant for sty^S73 for an R7 cell to form is the R7 cell itself. 98% of embryos derived from homozygous trk⁵ females terminate in the A7 abdominal segment. If the females are also heterozygous for sty^S73, 53% of the embryos terminate in the A7 abdominal segment, 39% terminate in the A8 abdominal segment and 8% are wild type. 91.3% of embryos derived from homozygous tor³ females terminate in the A7 abdominal segment. If the females are also heterozygous for sty^S73, 75% of the embryos terminate in the A7 abdominal segment, 25% terminate in the A8 abdominal segment and 17% are wild type. The eye phenotype of flies expressing Egfr::tor^{t4021E.hs.sev} is dominantly enhanced by sty^S73.

(Casci et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sty^Δ5

(Casci et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a dominant suppressor of the rough eye phenotype of flies expressing argos^GMR.PC.

(Casci et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sty^-

(Lawrence et al., 2002)

sty^S73

(Zettl et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (4)

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