FlyBase Allele Report: Dmel\spi[s.sev]

General Information

Symbol

Dmel\spi^s.sev

Species

D. melanogaster

Name

FlyBase ID

FBal0056117

Feature type

allele

Associated gene

Dmel\spi

Associated Insertion(s)

Carried in Construct

P{Sev-sSpi}

Key Links

Transgenic product class

stop_gained

(Freeman, 1996)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

stop_gained

(Freeman, 1996)

Mutagen

in vitro construct

(Freeman, 1996)

Progenitor genotype

Carried in construct

P{Sev-sSpi}

Cytology

Description

Construct: Amino acid replacement: K129. 500bp mutated spi fragment (encoding only the extracellular fragment of the protein) cloned downstream of a sev@ promoter fragment (-967 to +89bp, FBrf0050856).

(Freeman, 1996)

Allele components

Component

Use(s)

Regulatory region(s)

sev

Encoded product / tool

spi

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Casci et al., 1999)

wild-type

(Freeman, 1996)

Phenotype Manifest In

cone cell

(Freeman, 1996)

eye

(Casci et al., 1999)

eye photoreceptor cell | ectopic

(Freeman, 1996)

photoreceptor cell R7 | ectopic

(Freeman, 1996)

pigment cell

(Freeman, 1996)

Detailed Description

Statement

Reference

Flies have abnormal eyes and a few ommatidia have ectopic outer photoreceptors or R7 cell. Later there is more dramatic overrecruitment of cone and pigment cells in pupal retinas.

(Freeman, 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

spi^s.sev has visible phenotype, enhanceable by sty[+]/sty^S73

(Casci et al., 1999)

spi^s.sev has visible phenotype, enhanceable by sty[+]/sty^S88

(Casci et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

spi^s.sev has eye phenotype, enhanceable by sty[+]/sty^S73

(Casci et al., 1999)

spi^s.sev has eye phenotype, enhanceable by sty[+]/sty^S88

(Casci et al., 1999)

Suppressed by

Statement

Reference

spi^s.sev has phenotype, suppressible by Egfr^f3

(Freeman, 1996)

Additional Comments

Genetic Interactions

Statement

Reference

The eye phenotype of flies expressing spi^s.sev is weakly dominantly enhanced by sty^S73 or sty^S88.

(Casci et al., 1999)

Halving the dose of Egfr (Egfr^f3) suppresses the spi^s.sev phenotype.

(Freeman, 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

spi^s.sev rescues spi^SCP1

(Freeman, 1996)

spi^s.sev rescues spi^SCP2

(Freeman, 1996)

Comments

spi^s.sev can rescue the eye specific mutations of spi^SCP1 and spi^SCP2.

(Freeman, 1996)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

spi^s.sev

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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