FB2024_03 , released June 25, 2024
Allele: Dmel\Mhc+t41.9
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General Information
Symbol
Dmel\Mhc+t41.9
Species
D. melanogaster
Name
FlyBase ID
FBal0061726
Feature type
allele
Associated gene
Dmel\Mhc
Associated Insertion(s)
Carried in Construct
P{Mhc+41.9}
Also Known As
IFI, pWMHC
Key Links
Transgenic product class
genomic_DNA
(Cripps et al., 1994)
wild_type
(Cripps et al., 1994)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Cripps et al., 1994)
wild_type
(Cripps et al., 1994)
Mutagen
in vitro construct
(Kronert et al., 1995, Cripps et al., 1994)
Progenitor genotype
Carried in construct
P{Mhc+41.9}
Cytology
Description

41.9kb fragment including the Mhc gene and about 9kb of 5' and 3' flanking sequences.

(Cripps et al., 1994)
Allele components
Component
Use(s)
Regulatory region(s)
Mhc
Encoded product / tool
Mhc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Mhc+t41.9 display a normal sarcomeric structure.

      (Salvi et al., 2012)

      Overexpression of Mhc in wild type flies (three copies) does not affect muscle function but may have slight effects upon myofibril organisation. Four copies has a severe effect on flight and jump ability reflecting mutant myofibrils in the indirect flight muscles (IFMs) and tergal depressor muscle of the trochanter (TDT). Only occasionally flies carrying five copies are observed and flies carrying six copies are never recovered. This indicates overexpression of Mhc can affect muscles in addition to the IFMs and TDT.

      (Cripps et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Mhc+t41.9 rescues MhcL1736P

      (Salvi et al., 2012)

      Mhc+t41.9 rescues Mhc1

      (Cripps et al., 1994)

      Mhc+t41.9 rescues Mhc2

      (Cripps et al., 1994)
      Partially rescues

      Mhc+t41.9 partially rescues MhcE1570K/Ifm(2)RU1[+]

      (Salvi et al., 2012)

      Mhc+t41.9 partially rescues MhcE1570K

      (Salvi et al., 2012)

      Mhc+t41.9 partially rescues Mhc6

      (Kronert et al., 1995)

      Mhc+t41.9 partially rescues Mhc10

      (Cripps et al., 1994)
      Fails to rescue

      Mhc+t41.9 fails to rescue MhcD1

      (Kronert et al., 1999)

      Mhc+t41.9 fails to rescue MhcD41

      (Kronert et al., 1999)

      Mhc+t41.9 fails to rescue MhcD45

      (Kronert et al., 1999)

      Mhc+t41.9 fails to rescue MhcD62

      (Kronert et al., 1999)

      Mhc+t41.9 fails to rescue Mhc13

      (Kronert et al., 1995)

      Mhc+t41.9 fails to rescue Mhc19

      (Kronert et al., 1995)
      Comments

      Expression of Mhc+t41.9 rescues the dorsal longitudinal muscle defects seen in MhcL1736P mutant flies. The flightlessness is not rescued.

      Expression of two copies of Mhc+t41.9 rescues the dorsal longitudinal muscle thinning seen in homozygous MhcE1570K mutants, with flies instead showing a similar hypercontraction phenotype to that seen in MhcE1570K heterozygotes. Expression of Mhc+t41.9 partially suppresses the sarcomere disruption seen in MhcE1570K mutants.

      Expression of Mhc+t41.9 partially rescues the hypercontraction phenotype seen in MhcE1570K/+ mutants, with flies displaying less fibre tearing.

      (Salvi et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mhc+t41.9
      Mhc+t50
      Name Synonyms
      Secondary FlyBase IDs
        References (8)