24bp in-frame deletion in exon 10 affecting the actin binding loop of the head domain.
Heterozygotes show defects in flight ability.
MhcD62, up101 has abnormal flight phenotype
MhcD62, wupAhdp-2 has abnormal flight phenotype
Mhc[+]/MhcD62, up101 has abnormal flight phenotype
Mhc[+]/MhcD62, wupAhdp-2 has abnormal flight phenotype
Mhc12/MhcD62 is a suppressor of indirect flight muscle cell phenotype of wupAhdp-3
Mhc[+]/MhcD62 is a suppressor of indirect flight muscle cell phenotype of up101
Mhc[+]/MhcD62 is a suppressor of indirect flight muscle cell phenotype of wupAhdp-2
MhcD62 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45b phenotype of wupAhdp-2
MhcD62 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45c phenotype of wupAhdp-2
MhcD62 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45d phenotype of wupAhdp-2
MhcD62 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45e phenotype of wupAhdp-2
MhcD62 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45f phenotype of wupAhdp-2
MhcD62 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45a phenotype of wupAhdp-2
The defects seen in wupAhdp-2 flies are suppressed by MhcD62/+; 16% of the double mutant adults have an upheld wing phenotype and 84% hold their wings in the normal position. The indirect flight muscle fibres have normal morphology. The defects seen in up101 flies are suppressed by MhcD62/+; 100% of the double mutant adults hold their wings in the normal position. The indirect flight muscle fibres have normal morphology.
Dominant suppressor of the heldup wing phenotype of wupAhdp-2; wupAhdp-2/Y ; MhcD62/+ males have a near normal wing position, but cannot jump or fly. Dorsolongitudinal muscle (DLM) fibres a to d appear almost normal in these flies, but DLM muscles e and f have gross structural defects near the posterior attachment site. The number of thick filaments per fibril is reduced compared to wild type. wupAhdp-2/Y ; MhcD1/MhcD62 flies have a high frequency of double thick filaments in the DLMs.
Selected as: a dominant suppressor of wupAhdp-2.