FB2024_03 , released June 25, 2024
Allele: Dmel\Mhc2
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General Information
Symbol
Dmel\Mhc2
Species
D. melanogaster
Name
FlyBase ID
FBal0012243
Feature type
allele
Associated gene
Dmel\Mhc
Associated Insertion(s)
springer{}Mhc2
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Cripps et al., 1994)
Mutagen
spontaneous
(Cripps et al., 1994)
Progenitor genotype
Associated Insertion(s)
springer{}Mhc2
Cytology
Description

springer is inserted 5bp 5' to exon 7d. springer is flanked by a 4bp target site duplication. The element is orientated such that they contain a consensus polyadenylation signal, which includes the canonical AAUAAA element, and a GU rich domain within 50 nt 3' of the cleavage site.

(Davis et al., 1998)

Insertion of a 10kb springer element into an intron upstream of exon 7d.

(Cripps et al., 1994)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes are flightless. Disruptions in the structure of the IFM myofibrils are seen - cracks are visible throughout the myofibril where no thick filaments are present.

      (Cripps et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      MhcD1

      (Kronert et al., 1999)

      MhcD41

      (Kronert et al., 1999)

      MhcD45

      (Kronert et al., 1999)

      MhcD62

      (Kronert et al., 1999)
      Rescued by

      Mhc2 is rescued by Mhc+t41.9

      (Cripps et al., 1994)
      Comments

      The flight ability and myofibril phenotypes are fully rescued by one copy of Mhc+t41.9. Duplicated copy of Mhc present on Dp(2;3)osp3 is insufficient to rescue lethality due to the presence of a second site lethal mutation. Mhc+t41.9 can rescue lethality when the second site lethal is recombined off the chromosome.

      (Cripps et al., 1994)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Mogami.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mhc2
      Name Synonyms
      Secondary FlyBase IDs
        References (5)