FlyBase Allele Report: Dmel\Mhc[D1]

General Information

Symbol

Dmel\Mhc^D1

Species

D. melanogaster

Name

FlyBase ID

FBal0097226

Feature type

allele

Associated gene

Dmel\Mhc

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Kronert et al., 1999)

Progenitor genotype

Cytology

Description

Amino acid replacement: D623G.

(Bernstein and Zhang, 1999.11.18)

Nucleotide substitution: A to G. Amino acid replacement: D to G. Mutation is in exon 10 at the base of the second loop (which is involved in actin binding) of the head domain.

(Kronert et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:16,777,142..16,777,142 [+]

Nucleotide change:

A16777142G

Reported nucleotide change:

A?G

Amino acid change:

Reported amino acid change:

D623G

(Bernstein and Zhang, 1999.11.18, Kronert et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal flight | dominant

(Kronert et al., 1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

Heterozygotes show defects in flight ability.

(Kronert et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Mhc^D1/Mhc[+] is a suppressor of visible phenotype of up¹⁰¹

(Nongthomba et al., 2003)

Mhc^D1/Mhc[+] is a suppressor of visible phenotype of wupA^hdp-2

(Nongthomba et al., 2003)

Mhc^D1 is a suppressor of visible | recessive phenotype of wupA^hdp-2

(Kronert et al., 1999)

NOT Suppressor of

Statement

Reference

Mhc^D1/Mhc¹² is a non-suppressor of visible phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Other

Statement

Reference

Mhc^D1, wupA^hdp-2 has abnormal flight phenotype

(Nongthomba et al., 2003)

Mhc^D1, up¹⁰¹ has abnormal flight phenotype

(Nongthomba et al., 2003)

Mhc^D1/Mhc[+], up¹⁰¹ has abnormal flight phenotype

(Nongthomba et al., 2003)

Mhc^D1/Mhc[+], wupA^hdp-2 has abnormal flight phenotype

(Nongthomba et al., 2003)

Phenotype Manifest In

Suppressor of

Statement

Reference

Mhc^D1/Mhc[+] is a suppressor of indirect flight muscle cell phenotype of up¹⁰¹

(Nongthomba et al., 2003)

Mhc^D1/Mhc[+] is a suppressor of wing phenotype of up¹⁰¹

(Nongthomba et al., 2003)

Mhc^D1/Mhc[+] is a suppressor of indirect flight muscle cell phenotype of wupA^hdp-2

(Nongthomba et al., 2003)

Mhc^D1/Mhc[+] is a suppressor of wing phenotype of wupA^hdp-2

(Nongthomba et al., 2003)

Mhc^D1 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45a phenotype of wupA^hdp-2

(Kronert et al., 1999)

Mhc^D1 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45b phenotype of wupA^hdp-2

(Kronert et al., 1999)

Mhc^D1 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45c phenotype of wupA^hdp-2

(Kronert et al., 1999)

Mhc^D1 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45d phenotype of wupA^hdp-2

(Kronert et al., 1999)

Mhc^D1 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45e phenotype of wupA^hdp-2

(Kronert et al., 1999)

Mhc^D1 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45f phenotype of wupA^hdp-2

(Kronert et al., 1999)

NOT Suppressor of

Statement

Reference

Mhc^D1/Mhc¹² is a non-suppressor of indirect flight muscle cell phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc^D1/Mhc¹² is a non-suppressor of wing phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The defects seen in wupA^hdp-2 flies are suppressed by Mhc^D1/+; 7% of the double mutant adults have an upheld wing phenotype and 93% hold their wings in the normal position. The indirect flight muscle fibres have normal morphology. The defects seen in up¹⁰¹ flies are suppressed by Mhc^D1/+; 4% of the double mutant adults hold their wings down, 18% have an upheld wing phenotype and 78% hold their wings in the normal position. The indirect flight muscle fibres have normal morphology.

(Nongthomba et al., 2003)

Dominant suppressor of the heldup wing phenotype of wupA^hdp-2; wupA^hdp-2/Y ; Mhc^D1/+ males have a near normal wing position, but cannot jump or fly. Dorsolongitudinal muscle (DLM) fibres a to d appear almost normal in these flies, but DLM muscles e and f are collapsed. The number of thick filaments per fibril is reduced compared to wild type. wupA^hdp-2/Y ; Mhc^D1/Mhc^D41 flies can jump. wupA^hdp-2/Y ; Mhc^D1/Mhc^D62 flies have a high frequency of double thick filaments in the DLMs.

(Kronert et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

Mhc¹

(Kronert et al., 1999)

Fails to complement

Mhc²

(Kronert et al., 1999)

Not rescued by

Mhc^D1 is not rescued by Mhc^+t41.9

(Kronert et al., 1999)

Comments

Mhc^D1 is occasionally viable in combination with Mhc¹.

(Kronert et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a dominant suppressor of wupA^hdp-2.

(Kronert et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

(Kronert et al., 1999)

Mhc^D1

Name Synonyms

Secondary FlyBase IDs

References (3)

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