FlyBase Allele Report: Dmel\Mhc[12]

General Information

Symbol

Dmel\Mhc¹²

Species

D. melanogaster

Name

FlyBase ID

FBal0012253

Feature type

allele

Associated gene

Dmel\Mhc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless | dominant

(Cripps et al., 1994)

Phenotype Manifest In

Detailed Description

Statement

Reference

Reduced viability when heterozygous with Df(2L)H20 or Mhc¹. Heterozygotes and homozygotes have a reduced Mhc content in thoracic muscles, other muscle groups are unaffected.

(Cripps et al., 1994)

Indirect flight muscles accumulate little or no MHC, have no thick filaments, and show no organized myofibrils. The four smaller cells of the TDT display reduction in thick filament number and myofibril size; large TDT cells unaffected. homozygous viable

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Mhc¹²/Mhc^D41 is a suppressor of visible phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc^2D is a suppressor of visible phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc¹² is a suppressor of visible phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

NOT Suppressor of

Statement

Reference

Mhc¹²/Mhc^2B is a non-suppressor of visible phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc^2F is a non-suppressor of visible phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc^D1/Mhc¹² is a non-suppressor of visible phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc^D41 is a non-suppressor of visible phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc^D62 is a non-suppressor of visible phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Phenotype Manifest In

Suppressor of

Statement

Reference

Mhc¹²/Mhc^2F is a suppressor of indirect flight muscle cell phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc¹² is a suppressor of indirect flight muscle cell phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc^D62 is a suppressor of indirect flight muscle cell phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc^D41 is a suppressor of wing phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc¹² is a suppressor of wing phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc^2D is a suppressor of wing phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

NOT Suppressor of

Statement

Reference

Mhc¹²/Mhc^2B is a non-suppressor of wing phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc^2F is a non-suppressor of wing phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc^D1/Mhc¹² is a non-suppressor of wing phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc^D41 is a non-suppressor of wing phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc^D62 is a non-suppressor of wing phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc^2D is a non-suppressor of indirect flight muscle cell phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc^2F is a non-suppressor of indirect flight muscle cell phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc^D1/Mhc¹² is a non-suppressor of indirect flight muscle cell phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc^D41 is a non-suppressor of indirect flight muscle cell phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Mhc¹²/Mhc^D45 is a non-suppressor of indirect flight muscle cell phenotype of wupA^hdp-3

(Nongthomba et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

41% of wupA^hdp-3/Y ; Mhc¹²/Mhc¹² flies have an upheld wing phenotype and 59% hold their wings normally. 41% of wupA^hdp-3/Y ; Mhc¹²/Mhc^2D flies have an upheld wing phenotype and 59% hold their wings normally. 61% of wupA^hdp-3/Y ; Mhc¹²/Mhc^D45 flies have an upheld wing phenotype and 39% hold their wings normally. The indirect flight muscles of wupA^hdp-3/Y ; Mhc¹²/Mhc^2B and wupA^hdp-3/Y ; Mhc¹²/Mhc^2F flies show a partial hypercontraction phenotype.

(Nongthomba et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Sparrow & Ball.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Mhc¹²

(Cozhimuttam Viswanathan et al., 2014, Vikhorev et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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