2bp insertion in exon 7a, inserting a stop codon. The mutation also produces a potential 5' splice junction (GTAGCT).
GTA
The T in alternative exon 7a is replaced with GTA, inserting a stop codon after aa 324 of Mhc-PA. The mutation also produces a potential 5' splice junction (GTAGCT).
Heterozygotes show defects in flight ability.
MhcD41, up101 has abnormal flight phenotype
MhcD41, wupAhdp-2 has abnormal flight phenotype
Mhc[+]/MhcD41, up101 has abnormal flight phenotype
Mhc[+]/MhcD41, wupAhdp-2 has abnormal flight phenotype
Mhc[+]/MhcD41 is a suppressor of indirect flight muscle cell phenotype of wupAhdp-2
Mhc[+]/MhcD41 is a suppressor of indirect flight muscle cell phenotype of up101
MhcD41 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45a phenotype of wupAhdp-2
MhcD41 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45b phenotype of wupAhdp-2
MhcD41 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45c phenotype of wupAhdp-2
MhcD41 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45d phenotype of wupAhdp-2
MhcD41 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45e phenotype of wupAhdp-2
MhcD41 is a suppressor of muscle cell of dorsal longitudinal indirect flight muscle 45f phenotype of wupAhdp-2
Mhc12/MhcD41 is a non-suppressor of indirect flight muscle cell phenotype of wupAhdp-3
The defects seen in wupAhdp-2 flies are suppressed by MhcD41/+; 4% of the double mutant adults hold their wings down, 2% have an upheld wing phenotype and 94% hold their wings in the normal position. The indirect flight muscle fibres have normal morphology. The defects seen in up101 flies are suppressed by MhcD41/+; 5% of the double mutant adults hold their wings down, 15% have an upheld wing phenotype and 80% hold their wings in the normal position. The indirect flight muscle fibres have normal morphology.
Dominant suppressor of the heldup wing phenotype of wupAhdp-2; wupAhdp-2/Y ; MhcD41/+ males have a near normal wing position, but cannot jump or fly. Dorsolongitudinal muscle (DLM) fibres a to d appear almost normal in these flies, but DLM muscles e and f have structural defects near the posterior end. The number of thick filaments per fibril is reduced compared to wild type. wupAhdp-2/Y ; MhcD1/MhcD41 flies can jump.
Selected as: a dominant suppressor of wupAhdp-2.