FB2024_03 , released June 25, 2024
Allele: Dmel\Mhc6
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General Information
Symbol
Dmel\Mhc6
Species
D. melanogaster
Name
FlyBase ID
FBal0012247
Feature type
allele
Associated gene
Dmel\Mhc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kronert et al., 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: R?H. Nucleotide substitution: G?A. R?H falls in the 16th exon.

(Kronert et al., 1995)

Mutation in the fln binding site on the myosin rod.

(Sparrow et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:16,785,618..16,785,618 [+]
Nucleotide change:

G16785618A

Reported nucleotide change:

G?A

Amino acid change:

R1559H | Mhc-PA; R1559H | Mhc-PB; R1559H | Mhc-PC; R1559H | Mhc-PD; R1559H | Mhc-PE; R1559H | Mhc-PF; R1559H | Mhc-PG; R1559H | Mhc-PH; R1559H | Mhc-PI; R1559H | Mhc-PK; R1559H | Mhc-PL; R1559H | Mhc-PM; R1559H | Mhc-PN; R1559H | Mhc-PO; R1559H | Mhc-PP; R1559H | Mhc-PQ; R1559H | Mhc-PR; R1559H | Mhc-PS; R1559H | Mhc-PT; R1559H | Mhc-PU; R1559H | Mhc-PV

Reported amino acid change:

R?H

(Kronert et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      indirect flight muscle cell

      (Kronert et al., 1995)

      myofibril & indirect flight muscle

      (Kronert et al., 1995)

      striated muscle thick filament & indirect flight muscle

      (Kronert et al., 1995)

      striated muscle thin filament & indirect flight muscle

      (Kronert et al., 1995)
      Detailed Description
      Statement
      Reference

      Myofibres of the indirect flight muscles of homozygous or Mhc6/Mhc1 flies (but not of heterozygous flies) often appear bunched at one attachment site, although the myofibre surface does remain attached at both attachment sites. This phenotype develops as the fly ages, with the myofibres appearing normal immediately after eclosion. The myofibrils of the indirect flight muscles have ultrastructural abnormalities in adult flies; the hexagonal packing of the thick and thin filaments is missing in some areas, and sarcomeres sometimes appear abnormal. The tergal depressor of the trochanter muscles appear normal.

      (Kronert et al., 1995)

      A homozygous viable allele. The indirect flight muscles develop myofibrils with almost normal structures but within the first 12 hours of adult life these muscles 'super-contract' and the muscle mass moves to one or other muscle attachment site. The myofibrillar structure is destroyed and muscle proteolysis occurs.

      (Sparrow et al., 1995)

      Heterozygotes have moderate flight ability. Hemizygotes are flightless.

      (Homyk and Emerson, 1988)

      Heterozygotes fly moderately well and display normal wing posture; hemizygotes flightless and occasionally have abnormal wing posture. Double heterozygotes with wupAhdp-101, fliH1, upint-3, up101; or upx; but not wupAhdp-2, much more nearly flightless than Mhc6/+; wing posture normal. homozygous viable

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Mhc6 is a non-suppressor of phenotype of wupAhdp-2

      (Kronert et al., 1999)
      Other
      Statement
      Reference

      Act88F8, Mhc6 has wing phenotype

      (Homyk and Emerson, 1988)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The heldout wing defects of wupAhdp-2 flies are not suppressed by Mhc6.

      (Kronert et al., 1999)

      Double heterozygotes with either upint-3, up101 or upx are flightless. Approximately two-thirds of heterozygotes also carrying rsd1 Act88F8 have an abnormal wing posture.

      (Homyk and Emerson, 1988)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      Mhc6 is partially rescued by Mhc+t41.9

      (Kronert et al., 1995)
      Comments

      The flightless phenotype of heterozygotes is partially rescued by two copies of Mhc+t41.9.

      (Kronert et al., 1995)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Mogami.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ifm(2)1
      (Homyk and Emerson, 1988)
      Mhc6
      (Henkin et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)