FlyBase Allele Report: Dmel\S[05671]

General Information

Symbol

Dmel\S⁰⁵⁶⁷¹

Species

D. melanogaster

Name

FlyBase ID

FBal0030177

Feature type

allele

Associated gene

Dmel\S

Associated Insertion(s)

P{PZ}S⁰⁵⁶⁷¹

Carried in Construct

Also Known As

S⁵⁶⁷¹

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}S⁰⁵⁶⁷¹

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity

(Brown and Freeman, 2003)

lethal (with S^rK134)

(Iyadurai et al., 2008)

lethal - all die during embryonic stage | recessive

(Forjanic et al., 1997)

some die during embryonic stage | recessive

(Forjanic et al., 1997)

visible | dominant

(Forjanic et al., 1997)

Phenotype Manifest In

eye

(Brown et al., 2007, Forjanic et al., 1997)

mesothoracic tarsal segment 1 & bract

(Held, 2002)

mesothoracic tibial bract

(Held, 2002)

ommatidium

(Brown et al., 2007, Brown and Freeman, 2003)

photoreceptor

(Brown and Freeman, 2003)

photoreceptor cell R2

photoreceptor cell R5

photoreceptor cell R8

presumptive embryonic/larval central nervous system

Detailed Description

Statement

Reference

Heterozygous animals show a weak rough eye phenotype, with ommatidia showing both rotation and recruitment defects.

(Brown et al., 2007)

Heterozygous adults exhibit some weakly misrotated ommatidia, as well as a defect in photoreceptor cell recruitment.

(Brown and Freeman, 2003)

Heterozygotes have a missing-bract phenotype (31% of bracts in the tibia and 89% in the basitarsus of the second leg remain).

(Held, 2002)

Adults exhibit rough eyes.

(Forjanic et al., 1997)

Clonal analysis reveals mutant phenotypes in photoreceptor cells and wing veins.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

S⁰⁵⁶⁷¹ has abnormal cell polarity phenotype, enhanceable by shg^k03401

(Brown and Freeman, 2003)

S⁰⁵⁶⁷¹ has abnormal cell polarity phenotype, enhanceable by spi^SCP1/spi[+]

(Brown and Freeman, 2003)

S⁰⁵⁶⁷¹ has abnormal cell polarity phenotype, enhanceable by shg¹

(Brown and Freeman, 2003)

S⁰⁵⁶⁷¹ has abnormal cell polarity phenotype, enhanceable by shg²

(Brown and Freeman, 2003)

NOT Enhanced by

Statement

Reference

S⁰⁵⁶⁷¹ has abnormal cell polarity phenotype, non-enhanceable by mys¹

(Brown and Freeman, 2003)

S⁰⁵⁶⁷¹ has abnormal cell polarity phenotype, non-enhanceable by wb⁰⁹⁴³⁷

(Brown and Freeman, 2003)

NOT suppressed by

Statement

Reference

S⁰⁵⁶⁷¹ has abnormal cell polarity phenotype, non-suppressible by mys¹

(Brown and Freeman, 2003)

S⁰⁵⁶⁷¹ has abnormal cell polarity phenotype, non-suppressible by wb⁰⁹⁴³⁷

(Brown and Freeman, 2003)

Enhancer of

Statement

Reference

S⁰⁵⁶⁷¹ is an enhancer of visible | dominant phenotype of Kr^If-1

(Abrell et al., 2000)

Other

Statement

Reference

Dhc64C^6-10, S⁰⁵⁶⁷¹ has visible phenotype

(Iyadurai et al., 2008)

Dhc64C^γ4163a, S⁰⁵⁶⁷¹ has visible phenotype

(Iyadurai et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

S⁰⁵⁶⁷¹ has eye phenotype, enhanceable by Df(3L)Krn²⁶⁰/Df(3L)Krn²⁶⁰

(Brown et al., 2007)

S⁰⁵⁶⁷¹ has ommatidium phenotype, enhanceable by Df(3L)Krn²⁶⁰/Df(3L)Krn²⁶⁰

(Brown et al., 2007)

S⁰⁵⁶⁷¹ has eye phenotype, enhanceable by Df(3L)Krn-27-7-B/Df(3L)Krn-27-7-B

(Brown et al., 2007)

S⁰⁵⁶⁷¹ has ommatidium phenotype, enhanceable by Df(3L)Krn-27-7-B/Df(3L)Krn-27-7-B

(Brown et al., 2007)

S⁰⁵⁶⁷¹ has eye phenotype, enhanceable by Krn^RNAi.UAS/Scer\GAL4^GMR.PF

(Brown et al., 2007)

S⁰⁵⁶⁷¹ has ommatidium phenotype, enhanceable by Krn^RNAi.UAS/Scer\GAL4^GMR.PF

(Brown et al., 2007)

S⁰⁵⁶⁷¹ has ommatidium phenotype, enhanceable by shg²

(Brown and Freeman, 2003)

S⁰⁵⁶⁷¹ has ommatidium phenotype, enhanceable by shg^k03401

(Brown and Freeman, 2003)

S⁰⁵⁶⁷¹ has ommatidium phenotype, enhanceable by spi^SCP1/spi[+]

(Brown and Freeman, 2003)

S⁰⁵⁶⁷¹ has photoreceptor phenotype, enhanceable by spi^SCP1/spi[+]

(Brown and Freeman, 2003)

S⁰⁵⁶⁷¹ has ommatidium phenotype, enhanceable by shg¹

(Brown and Freeman, 2003)

S⁰⁵⁶⁷¹ has mesothoracic tarsal segment 1 & bract phenotype, enhanceable by Ras85D^e1B

(Held, 2002)

S⁰⁵⁶⁷¹ has mesothoracic tibial bract phenotype, enhanceable by Ras85D^e1B

(Held, 2002)

NOT Enhanced by

Statement

Reference

S⁰⁵⁶⁷¹ has ommatidium phenotype, non-enhanceable by mys¹

(Brown and Freeman, 2003)

S⁰⁵⁶⁷¹ has ommatidium phenotype, non-enhanceable by wb⁰⁹⁴³⁷

(Brown and Freeman, 2003)

NOT suppressed by

Statement

Reference

S⁰⁵⁶⁷¹ has ommatidium phenotype, non-suppressible by mys¹

(Brown and Freeman, 2003)

S⁰⁵⁶⁷¹ has ommatidium phenotype, non-suppressible by wb⁰⁹⁴³⁷

(Brown and Freeman, 2003)

Enhancer of

Statement

Reference

S⁰⁵⁶⁷¹ is an enhancer of eye phenotype of DCTN1-p150^Gl-1

(Iyadurai et al., 2008)

S⁰⁵⁶⁷¹ is an enhancer of mesothoracic tarsal segment 1 & bract phenotype of Ras85D^e1B

(Held, 2002)

S⁰⁵⁶⁷¹ is an enhancer of bract phenotype of Ras85D^e1B

(Held, 2002)

S⁰⁵⁶⁷¹ is an enhancer of eye phenotype of Kr^If-1

(Abrell et al., 2000)

S⁰⁵⁶⁷¹ is an enhancer of ommatidium phenotype of Kr^If-1

(Abrell et al., 2000)

S⁰⁵⁶⁷¹ is an enhancer of eye phenotype of bun^rI043

(Treisman et al., 1995)

Suppressor of

Statement

Reference

S⁰⁵⁶⁷¹ is a suppressor of phenotype of rho^hs.sev

(Freeman, 1994)

Other

Statement

Reference

Dhc64C^6-10, S⁰⁵⁶⁷¹ has wing vein L5 phenotype

(Iyadurai et al., 2008)

Dhc64C^γ4163a, S⁰⁵⁶⁷¹ has wing vein L5 phenotype

(Iyadurai et al., 2008)

Krn^RNAi.UAS, S⁰⁵⁶⁷¹, Scer\GAL4^GMR.PF has eye photoreceptor cell | increased number phenotype

(Brown et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Dhc64C^γ4163a S⁰⁵⁶⁷¹ and Dhc64C^6-10 S⁰⁵⁶⁷¹ transheterozygotes have an incomplete L5 wing vein which does not reach the wing margin.

(Iyadurai et al., 2008)

S⁰⁵⁶⁷¹/+, Df(3L)Krn²⁶⁰/Df(3L)Krn²⁶⁰ flies show a stronger rough eye than S⁰⁵⁶⁷¹/+ alone, with many more ommatidia being misrotated. Occasional achiral ommatidia are observed.

S⁰⁵⁶⁷¹/+, Df(3L)Krn-27-7-B/Df(3L)Krn-27-7-B flies show a severe enhancement of the S⁰⁵⁶⁷¹/+ eye phenotype. Both ommatidial rotation and recruitment defects are observed, with many ommatidia having too few photoreceptors. Occasional achiral ommatidia are observed.

Scer\GAL4^GMR.PF-driven expression of Krn^{dsRNA.Scer\UAS} enhances the S⁰⁵⁶⁷¹/+ eye phenotype. Both ommatidial rotation and recruitment defects are observed. Around 2% of ommatidia have too many photoreceptors. Occasional achiral ommatidia are observed.

(Brown et al., 2007)

Heterozygosity for spi^SCP1 enhances both the photoreceptor cell recruitment and misrotation phenotypes seen in S⁰⁵⁶⁷¹/+ animals. Heterozygous wb⁰⁹⁴³⁷ or mys¹ has no effect on the S⁰⁵⁶⁷¹/+ ommatidial polarity phenotype. Heterozygous shg¹, shg^k03401, or shg² significantly enhances the ommatidial misrotation phenotype seen S⁰⁵⁶⁷¹/+ animals.

(Brown and Freeman, 2003)

Ras85D^e1B/+, S⁰⁵⁶⁷¹/+ double mutants have a stronger missing-bract phenotype than either mutant alone. (2% of bracts in the tibia and 60% in the basitarsus of the second leg remain). The addition of Ras85D^hs.M11.2 under heat shock control partially suppresses this phenotype.

(Held, 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Spradling group.

Comments

Complements: l(2)k06107^k06107.

(BDGP Project Members, 1994-1999)

Excision of the P{PZ} element results in viability demonstrating the insertion to be responsible for lethality.

(Forjanic et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

S⁰⁵⁶⁷¹

(Iyadurai et al., 2008)

S⁵⁶⁷¹

(Brown et al., 2007, Brown and Freeman, 2003, Held, 2002, Schweitzer et al., 1995, Treisman et al., 1995, Freeman, 1994)

S^S5671

(Clegg et al., 1997)

l(2)05671

(Abrell et al., 2000)

l(2)5671

(Forjanic et al., 1997)

Name Synonyms

Secondary FlyBase IDs

FBal0045045

References (14)

Report Sections

Open Close