FlyBase Allele Report: Dmel\Su(z)2[1]

General Information

Symbol

Dmel\Su(z)2¹

Species

D. melanogaster

Name

FlyBase ID

FBal0028569

Feature type

allele

Associated gene

Dmel\Su(z)2

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

gain of function allele

antimorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Muller et al., 1999, Adler et al., 1991, Adler et al., 1989)

gain of function allele

(Wu and Howe, 1995, Cheng et al., 1994, Brunk et al., 1991)

Mutagen

ethyl methanesulfonate

(Wu and Howe, 1995, Adler et al., 1991, Adler et al., 1989, Kalisch and Rasmuson, 1974)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Wu and Howe, 1995, Brunk and Adler, 1990)

Description

Amino acid replacement: L120F.

(Emmons et al., 2009)

The nonsense mutation occurs shortly after the the HTH domain and is expected to produce a truncated protein.

(Emmons et al., 2009)

Amino acid replacement: K284term.

(Emmons et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:12,999,995..12,999,995 [+]

Nucleotide change:

G12999995Y

Amino acid change:

L120F | Su(z)2-PA; L120F | Su(z)2-PB; L120F | Su(z)2-PC

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Emmons et al., 2009)

point_mutation

2R:13,001,119..13,001,119 [+]

Nucleotide change:

A13001119T

Amino acid change:

K284term | Su(z)2-PA; K284term | Su(z)2-PB; K284term | Su(z)2-PC

Reported amino acid change:

K284term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Emmons et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color | dominant

(Brunk et al., 1991)

lethal (with Su(z)2^e26)

(Emmons et al., 2009)

lethal (with Su(z)2^s20)

(Emmons et al., 2009)

lethal (with Su(z)2^s36)

(Emmons et al., 2009)

lethal (with Su(z)2^s84)

(Emmons et al., 2009)

lethal (with Su(z)2^s95)

(Emmons et al., 2009)

lethal | recessive

(Wu et al., 1989, Kalisch and Rasmuson, 1974)

lethal - all die during embryonic stage

(Wu and Howe, 1995)

non-suppressor of variegation | dominant, with In(1)w^m4

(Doheny et al., 2008)

non-suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

(Doheny et al., 2008)

partially lethal - majority die (with Su(z)2^3-1)

(Emmons et al., 2009)

partially lethal - majority die (with Su(z)2^eos)

(Emmons et al., 2009)

partially lethal - majority die (with Su(z)2^s15)

(Emmons et al., 2009)

partially lethal - majority die (with Su(z)2^s21)

(Emmons et al., 2009)

partially lethal - majority die (with Su(z)2^sM)

(Emmons et al., 2009)

some die during embryonic stage

(Wu and Howe, 1995)

Phenotype Manifest In

macrochaeta

(Wu and Howe, 1995)

pigment cell

(Brunk et al., 1991, Kalisch and Rasmuson, 1974)

Detailed Description

Statement

Reference

One copy of Su(z)2¹ is unable to suppress position effect variegation (PEV) at the w locus caused by In(1)w^m4.

One copy of Su(z)2¹ is unable to suppress the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

(Doheny et al., 2008)

Su(z)2¹ shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w^+mW.hs allele at the telomeres of the second and third chromosome.

(Cryderman et al., 1999)

Suppresses z¹ in In(1)w^m4 and In(1)rst³ but has little effect on z^v77h in these combinations. Suppressor of z¹ w^zl, z^v77h w^zl and z¹ w^zm but has no effect on z^v77h w^zm.

(Judd, 1995)

Chaetae loss phenotype of Su(z)2¹/Df(2R)vg62 or Su(z)2¹/Df(2R)vg-D is stronger than for Su(z)2⁴/Df(2R)vg62 or Su(z)2⁴/Df(2R)vg-D. Hemizygotes die as larvae/pupae.

(Wu and Howe, 1995)

No homeotic phenotype and the mutation cannot enhance the homeotic phenotypes of Pc group mutants (FBrf0049524).

(Cheng et al., 1994)

In z¹ w^zm strain mutation causes reduction of eye pigmentation. Slightly suppress w phenotype in a e(y) background.

(Georgiev, 1994)

Heterozygotes with Df(2R)vg62 and with Df(2R)vg-D exhibit enhanced depilate phenotypes.

(Cripps and Sparrow, 1989)

Heterozygotes have reduced viability. Fertile at 25^oC.

(Kalisch and Rasmuson, 1974)

zeste-->red eyes

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Su(z)2¹/Su(z)2[+] is an enhancer of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Su(z)2¹/Su(z)2[+] is an enhancer of visible phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Su(z)2¹/Su(z)2[+] is an enhancer of visible | dominant | homeotic phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

Su(z)2¹/Su(z)2[+] is an enhancer of visible | dominant | homeotic phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Suppressor of

Statement

Reference

Su(z)2¹/Su(z)2[+] is a suppressor of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Su(z)2¹ is a suppressor of visible phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Su(z)2¹/Su(z)2[+] is a suppressor of visible phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

Su(z)2¹ is a suppressor of abnormal eye color phenotype of z¹

(Wu et al., 1989)

Other

Statement

Reference

Su(z)2¹, ash1²² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Su(z)2¹, brm² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Su(z)2¹/Su(z)2[+], ash1²² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Su(z)2¹/Su(z)2[+], brm² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Psc¹⁴⁴⁵, Su(z)2¹ has visible | dominant phenotype

(Wu and Howe, 1995)

Psc^e23, Su(z)2¹ has visible | dominant phenotype

(Wu and Howe, 1995)

Psc^e24, Su(z)2¹ has visible | dominant phenotype

(Wu and Howe, 1995)

Psc^e25, Su(z)2¹ has visible | dominant phenotype

(Wu and Howe, 1995)

Psc^h27, Su(z)2¹ has visible | dominant phenotype

(Wu and Howe, 1995)

Phenotype Manifest In

Enhancer of

Statement

Reference

Su(z)2¹/Su(z)2[+] is an enhancer of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Su(z)2¹/Su(z)2[+] is an enhancer of eye phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Su(z)2¹/Su(z)2[+] is an enhancer of adult metathoracic segment phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

Su(z)2¹/Su(z)2[+] is an enhancer of adult metathoracic segment phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Suppressor of

Statement

Reference

Su(z)2¹/Su(z)2[+] is a suppressor of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Su(z)2¹ is a suppressor of eye phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Su(z)2¹/Su(z)2[+] is a suppressor of 1st posterior cell phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

Su(z)2¹ is a suppressor of phenotype of z¹

(Brunk et al., 1991, Kalisch and Rasmuson, 1974)

Su(z)2¹/Su(z)2[+] is a suppressor of phenotype of z¹

(Brunk and Adler, 1990)

Other

Statement

Reference

Su(z)2¹, ash1²² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Su(z)2¹, brm² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Su(z)2¹/Su(z)2[+], ash1²² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Su(z)2¹/Su(z)2[+], brm² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Psc¹⁴⁴⁵, Su(z)2¹ has microchaeta phenotype

(Wu and Howe, 1995)

Psc^e23, Su(z)2¹ has microchaeta phenotype

(Wu and Howe, 1995)

Psc^e24, Su(z)2¹ has microchaeta phenotype

(Wu and Howe, 1995)

Psc^e25, Su(z)2¹ has microchaeta phenotype

(Wu and Howe, 1995)

Psc^h27, Su(z)2¹ has microchaeta phenotype

(Wu and Howe, 1995)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is ameliorated by combination with a single copy of Su(z)2¹.

(Morimoto et al., 2016)

Has no effect on the frequency of X-Y chromosome nondisjunction seen in Df(1)X-1-53B males, but acts as a meiotic drive suppressor, suppressing drive against the X and Y chromosomes in these flies. Suppresses meiotic drive of the Y chromosome in Df(1)X-1 males compared to controls.

(McKee et al., 2000)

The addition of Su(z)2¹ suppresses the Pairing sensitive silencing effect seen in w^Mcp.scs'.21 and w^Mcp.y.scs'.1 and strongly suppresses the eye colour phenotype of double insertion combinations of w^Mcp.scs'.21/y^we.Mcp.1 (P{Mcp-w#21}124/+, P{Mcp-wy#1}183/+) and w^Mcp.y.scs'.1/y^we.Mcp.2 (P{Mcp-yw#1}103/+, P{Mcp-wy#2}50/+).

(Muller et al., 1999)

Has no effect on the phenotypes of ct^2s, ct^4s and ct⁶, where the wing margin enhancer is completely blocked, or ct^pN2s or ct^n2s.

(Melnikova et al., 1996)

Complete suppression of z¹ phenotype, eyes are wild-type in colour. Eye color of heterozygous females which are also z¹/z¹ : wild type. Eye color of heterozygous males which are also z¹, w^is/Y: wild type.

(Wu and Howe, 1995)

Dominant suppressor of z¹ interaction with w.

(Brunk et al., 1991)

Dominant suppressor of the z¹ interaction with w.

(Brunk and Adler, 1990)

Heterozygous flies modify the yellow eyes of z¹ to red: dominant suppressors of z¹ eye colour.

(Wu et al., 1989)

Very strong suppression of the z/w interaction causing darkening of the eye pigmentation.

(Kalisch and Rasmuson, 1974)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is exacerbated by combination with a single copy of Su(z)2¹.

(Morimoto et al., 2016)

Complementation and Rescue Data

Complements

Su(z)2^vgD

(Brunk et al., 1991)

Su(z)2^vg62

(Brunk et al., 1991)

Su(z)2^Arp1

(Brunk et al., 1991)

Su(z)2^Arp.4

(Brunk et al., 1991)

Partially complements

Su(z)2^sM

(Emmons et al., 2009)

Su(z)2^s21

(Emmons et al., 2009)

Su(z)2^s15

(Emmons et al., 2009)

Fails to complement

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

5573

sc¹ z¹ w^is; Su(z)2¹/CyO

Kyoto

108307

sc¹ z¹ w^is; Su(z)2¹/CyO

Notes on Origin

Discoverer

Rasmuson.

Comments

Fails to complement: Psc¹. Complements: Psc^Arp.1. Complements: Psc^1.d20. Complements: Psc^14P4. Complements: Su(z)3¹. Fails to complement: Su(z)3^1.y. Complements: l(2)49Dc¹.

(Brunk et al., 1991)

Lethal when heterozygous with Psc¹. Recombinationally mapped distal to distal breakpoint of Df(2R)vg62.

(Wu and Howe, 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Su(z)2¹

(Bengani et al., 2013)

Su(z)¹

(Cryderman et al., 1999)

Su(z)²

Name Synonyms

Secondary FlyBase IDs

FBal0013981

References (33)

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