FlyBase Allele Report: Dmel\Su(z)2[Arp1]

General Information

Symbol

Dmel\Su(z)2^Arp1

Species

D. melanogaster

Name

FlyBase ID

FBal0034079

Feature type

allele

Associated gene

Dmel\Su(z)2

Associated Insertion(s)

P{}Su(z)2^Arp1

Carried in Construct

Key Links

Allele class

gain of function allele

Mutagen

Nature of the Allele

Allele class

gain of function allele

(Sharp et al., 1994, Brunk et al., 1991, Brunk and Adler, 1990, Adler et al., 1989)

Mutagen

PM hybrid dysgenesis

P-element activity

(Brunk and Adler, 1990)

Progenitor genotype

Associated Insertion(s)

P{}Su(z)2^Arp1

Caused by aberration

In(2R)Arp1

Cytology

Associated with In(2R)Arp1 with P-derived sequences at either end. Deficiency analysis shows that lethality common to Su(z)2^Arp1 and Su(z)2^Arp2 associated with the 49A12-B3 breakpoint. Reverts by reinversion in dysgenic (1/200) and control (1/2000) crosses.

Description

In situ hybridization with P element probe shows P element at both ends of the inversion. P element at the proximal breakpoint thought not to be in exon, and to be phenotypically silent, and is 0.8kb smaller in Su(z)2^Arp2 than it is in Su(z)2^Arp1.

(Brunk and Adler, 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Brunk and Adler, 1990)

lethal - all die during embryonic stage | recessive

(Adler, 1984)

some die during embryonic stage | recessive

(Adler, 1984)

visible

(Sharp et al., 1994)

visible | dominant

(Brunk et al., 1991, Adler, 1984)

Phenotype Manifest In

arista

(Sharp et al., 1994, Brunk et al., 1991, Adler, 1984)

macrochaeta

(Brunk et al., 1991)

thorax & macrochaeta

(Adler, 1984)

Detailed Description

Statement

Reference

Mutation does not affect the level of w expression in ph-p^lac+3 flies.

(Fauvarque et al., 1995)

Synergistic interaction exists with Su(z)2^hs.PS, double heterozgous flies raised at 25 or 29^oC display an enhanced bristle phenotype and enhance the arista to tarsus transformation of Su(z)2^Arp1. There is no interaction with Psc^hs.PS.

(Sharp et al., 1994)

Bristle development on the scutellar and dorsocentral macrochaetae on the dorsal thorax is affected: bristles reduced in size or missing. Aristae are transformed towards the tarsus. In double mutants of Df(2R)vg-D and Su(z)2^Arp1 dramatic synergism is seen.

(Brunk et al., 1991)

Partial transformation of arista towards tarsus and loss or decrease in size of the dorsocentral or scutellar bristles: variable expressivity and 100% penetrance.

(Brunk and Adler, 1990)

Heterozygotes exhibit dominant partial transformation of arista to tarsus and a partial loss of the large medial thoracic bristles.

(Adler, 1984)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Su(z)2^Arp1/Su(z)2[+] is an enhancer of visible | dominant | homeotic phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

Su(z)2^Arp1 has phenotype, enhanceable by Dll¹³⁸⁷/Dll[+]

(Brunk and Adler, 1990)

Enhancer of

Statement

Reference

Su(z)2^Arp1/Su(z)2[+] is an enhancer of adult metathoracic segment phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Su(z)2¹

(Brunk et al., 1991)

Su(z)2^Arp.1

(Brunk et al., 1991)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Unstable, reverting spontaneously at a frequency of 0.02%, and, under dysgenic conditions, at a frequency of 2%. Wild type revertants show wild type cytology.

(Brunk and Adler, 1990)

Complements: Psc¹. Complements: Psc^Arp.1.

(Brunk et al., 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Arp¹

(Brunk et al., 1991)

Su(z)2^Arp1

Su(z)2^arp1

(Ronsseray et al., 1996)

Su(z)2^arp

(Gildea et al., 2000)

Su(z)2^arpI1

(Ronsseray et al., 1996)

Name Synonyms

Secondary FlyBase IDs

FBal0000721

References (11)

Report Sections

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