FB2024_03 , released June 25, 2024
Allele: Dmel\Su(z)24
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General Information
Symbol
Dmel\Su(z)24
Species
D. melanogaster
Name
FlyBase ID
FBal0028572
Feature type
allele
Associated gene
Dmel\Su(z)2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Brunk et al., 1991)
Mutagen
X ray
(Wu and Howe, 1995)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Wu and Howe, 1995)
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Su(z)24 shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w+mW.hs allele at the telomeres of the second and third chromosome.

      (Cryderman et al., 1999)

      Chaetae loss phenotype of Su(z)24/Df(2R)vg62 or Su(z)24/Df(2R)vg-D is weaker than for Su(z)21/Df(2R)vg62 or Su(z)21/Df(2R)vg-D. Hemizygotes die as larvae/pupae.

      (Wu and Howe, 1995)

      In z1 wzm strain mutation causes reduction of eye pigmentation.

      (Georgiev, 1994)

      Heterozygotes with Df(2R)vg62 and with Df(2R)vg-D exhibit enhanced depilate phenotypes.

      (Cripps and Sparrow, 1989)

      zeste-->orange-maroon eyes

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Su(z)24 is a suppressor of abnormal eye color phenotype of z1

      (Wu et al., 1989)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Su(z)24 is a suppressor of phenotype of z1

      (Wu and Howe, 1995, Brunk et al., 1991)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Has no effect on the phenotypes of ct2s, ct4s and ct6, where the wing margin enhancer is completely blocked, or ctpN2s or ctn2s.

      (Melnikova et al., 1996)

      Suppression of z1 eye color, towards wild-type colour. Eye color of heterozygous females which are also z1/z1 : maroon (with subtle speckling). Eye color of heterozygous males which are also z1, wis/Y: maroon. Su(z)24 dominantly enhances the homeotic effect of the Psc "hopeful" alleles.

      (Wu and Howe, 1995)

      Dominant suppressor of z1 interaction with w.

      (Brunk et al., 1991)

      Heterozygous flies modify the yellow eyes of z1 to orange maroon: dominant suppressors of z1 eye colour.

      (Wu et al., 1989)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Gelbart.

      Su(z)24 is an unstable allele as two isolates have been identified with distinct molecular signatures. Both isolates contain an 8-bp deletion in exon 5, but one (termed Su(z)24-34) contains an ~9kb insertion in intron 1 while the other (termed Su(z)24-31) does not. It is not certain that either isolate corresponds to the original Su(z)24 mutation.

      (Emmons et al., 2009)
      Comments
      Comments

      Order of suppression strength: Su(z)22 > Su(z)23 > Su(z)24.

      (Kalisch and Rasmuson, 1974)

      Fails to complement: Psc1. Complements: PscArp.1.

      (Brunk et al., 1991)

      Reduced viability when heterozygous with Psc1.

      (Wu and Howe, 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Su(2)z45
      Su(z)24
      (Di Stefano et al., 2011, Emmons et al., 2009)
      Su(z)45
      Su(z)4
      (Cryderman et al., 1999)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0013984
      References (16)