FlyBase Allele Report: Dmel\Su(z)2[1.b7]

General Information

Symbol

Dmel\Su(z)2^1.b7

Species

D. melanogaster

Name

FlyBase ID

FBal0028570

Feature type

allele

Associated gene

Dmel\Su(z)2

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Soto et al., 1995)

loss of function allele

(Wu and Howe, 1995, Brunk et al., 1991)

Mutagen

X ray

gamma ray

(Wu and Howe, 1995)

Progenitor genotype

Su(z)2¹

(Emmons et al., 2009, Wu and Howe, 1995, Brunk et al., 1991, Adler et al., 1989)

Cytology

Polytene chromosomes normal.

(Wu and Howe, 1995)

Description

Amino acid replacement: K284term.

(Emmons et al., 2009)

Carries the nonsense mutation of its progenitor (Su(z)2¹) as well as a ~3.5kb deletion of the first two exons and a 4bp insertion (TTCT) at the site of the deletion. The putative TATA box is preserved 8bp upstream of the breakpoint, consistent with this allele being competent for transcription. (It is not known whether Su(z)2^1.b7 also carries the L120F mutation found in Su(z)2¹.)

(Emmons et al., 2009)

2kb deletion at the 5' end of the Su(z)2 promoter.

(Soto et al., 1995)

2kb deletion from 0 to +2 on the molecular map.

(Brunk et al., 1991)

2 kb deletion at 5' end of transcription unit

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Su(z)2^s84)

(Emmons et al., 2009)

lethal | recessive

(Wu and Howe, 1995)

non-suppressor of variegation | dominant, with In(1)w^m4

(Doheny et al., 2008)

partially lethal - majority die (with Su(z)2^3-1)

(Emmons et al., 2009)

partially lethal - majority die (with Su(z)2^e26)

(Emmons et al., 2009)

partially lethal - majority die (with Su(z)2^eos)

(Emmons et al., 2009)

partially lethal - majority die (with Su(z)2^s95)

(Emmons et al., 2009)

suppressor of variegation, with P{hsp26-pt-T}39C-5

(Cryderman et al., 1999)

suppressor of variegation, with P{hsp26-pt-T}39C-27

(Cryderman et al., 1999)

suppressor of variegation, with P{hsp26-pt-T}39C-31

(Cryderman et al., 1999)

suppressor of variegation, with P{hsp26-pt-T}39C-50

(Cryderman et al., 1999)

suppressor of variegation, with P{hsp26-pt-T}39C-51

(Cryderman et al., 1999)

suppressor of variegation, with P{hsp26-pt-T}39C-58

(Cryderman et al., 1999)

suppressor of variegation, with P{hsp26-pt-T}39C-62

(Cryderman et al., 1999)

suppressor of variegation, with P{hsp26-pt-T}118E-16

(Cryderman et al., 1999)

suppressor of variegation, with P{hsp26-pt-T}118E-26

(Cryderman et al., 1999)

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

(Doheny et al., 2008)

viable (with Su(z)2^s15)

(Emmons et al., 2009)

viable (with Su(z)2^s20)

(Emmons et al., 2009)

viable (with Su(z)2^s21)

(Emmons et al., 2009)

viable (with Su(z)2^s36)

(Emmons et al., 2009)

viable (with Su(z)2^sM)

(Emmons et al., 2009)

Phenotype Manifest In

pigment cell

(Wu and Howe, 1995)

Detailed Description

Statement

Reference

One copy of Su(z)2^1.b7 is unable to suppress position effect variegation (PEV) at the w locus caused by In(1)w^m4.

One copy of Su(z)2^1.b7 moderately suppresses the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

(Doheny et al., 2008)

Su(z)2^1.b7 can show a strong dominant suppression on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w^+mW.hs allele at the telomeres of the second and third chromosome. Has no effect on pericentric and fourth chromosome insertions.

(Cryderman et al., 1999)

Mutation does not affect the level of w expression in ph-p^lac+3 flies.

(Fauvarque et al., 1995)

Cuticles of embryos lacking both zygotic and maternal Su(z)2 contribution show no defects apart from occasional head defects.

(Soto et al., 1995)

Isolated on the basis of reverting the dominant z¹ eye color suppression associated with Su(z)2¹. In a z¹, w^is/Y background, Su(z)2^1.b7 produces an orange eye colour similar to that found in z¹, w^is/Y;+/+. The reversion event simultaneously reverted the ability of Su(z)2¹ to enhance the dominant loss of chaetae phenotype associated with Su(z)2^vg62 (Df(2R)vg62) and Su(z)2^vgD (Df(2R)vg-D). Heterozygotes with Df(2R)vg-D are viable. Hemizygotes die as larvae/pupae.

(Wu and Howe, 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Su(z)2^1.b7/Su(z)2[+] is an enhancer of visible phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Ji et al., 2012)

NOT Enhancer of

Statement

Reference

Su(z)2^1.b7/Su(z)2[+] is a non-enhancer of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Su(z)2^1.b7/Su(z)2[+] is a non-enhancer of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Su(z)2^1.b7/Su(z)2[+] is a non-enhancer of visible phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Suppressor of

Statement

Reference

Su(z)2^1.b7/Su(z)2[+] is a suppressor of visible phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

Su(z)2^1.b7 is a suppressor of visible phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Su(z)2^1.b7 is a suppressor of visible phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

NOT Suppressor of

Statement

Reference

Su(z)2^1.b7/Su(z)2[+] is a non-suppressor of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Su(z)2^1.b7/Su(z)2[+] is a non-suppressor of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Su(z)2^1.b7/Su(z)2[+] is a non-suppressor of visible phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Phenotype Manifest In

Enhancer of

Statement

Reference

Su(z)2^1.b7/Su(z)2[+] is an enhancer of wing phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Ji et al., 2012)

NOT Enhancer of

Statement

Reference

Su(z)2^1.b7/Su(z)2[+] is a non-enhancer of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Su(z)2^1.b7/Su(z)2[+] is a non-enhancer of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Su(z)2^1.b7/Su(z)2[+] is a non-enhancer of eye phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Suppressor of

Statement

Reference

Su(z)2^1.b7/Su(z)2[+] is a suppressor of 1st posterior cell phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

Su(z)2^1.b7 is a suppressor of eye phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Su(z)2^1.b7 is a suppressor of eye phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

NOT Suppressor of

Statement

Reference

Su(z)2^1.b7/Su(z)2[+] is a non-suppressor of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Su(z)2^1.b7/Su(z)2[+] is a non-suppressor of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Su(z)2^1.b7/Su(z)2[+] is a non-suppressor of eye phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is not affected by combination with a single copy of Su(z)2^1.b7.

(Morimoto et al., 2016)

Has no effect on the frequency of X-Y chromosome nondisjunction seen in Df(1)X-1-53B males, but acts as a meiotic drive suppressor, suppressing drive against the X and Y chromosomes in these flies.

(McKee et al., 2000)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is not affected by combination with a single copy of Su(z)2^1.b7.

(Morimoto et al., 2016)

Complementation and Rescue Data

Complements

Su(z)2^sM

(Emmons et al., 2009)

Su(z)2^s36

(Emmons et al., 2009)

Su(z)2^s21

(Emmons et al., 2009)

Su(z)2^s20

(Emmons et al., 2009)

Su(z)2^s15