FlyBase Allele Report: Dmel\Su(z)2[e26]

General Information

Symbol

Dmel\Su(z)2^e26

Species

D. melanogaster

Name

FlyBase ID

FBal0045168

Feature type

allele

Associated gene

Dmel\Su(z)2

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Wu and Howe, 1995)

Progenitor genotype

Cytology

Description

A H53Y missense mutation in the RF domain, which is expected to severely disrupt the RF and compromise Su(z)2 function.

(Emmons et al., 2009)

Amino acid replacement: H53Y.

(Emmons et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:12,999,492..12,999,492 [+]

Nucleotide change:

C12999492T

Amino acid change:

H53Y | Su(z)2-PA; H53Y | Su(z)2-PB; H53Y | Su(z)2-PC

Reported amino acid change:

H53Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Emmons et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Su(z)2¹)

(Emmons et al., 2009)

lethal (with Su(z)2^4-31)

(Emmons et al., 2009)

lethal (with Su(z)2^4-34)

(Emmons et al., 2009)

non-suppressor of variegation | dominant, with In(1)w^m4

(Doheny et al., 2008)

partially lethal - majority die

(Emmons et al., 2009)

partially lethal - majority die (with Df(2R)Su(z)2-1.b8)

(Emmons et al., 2009)

partially lethal - majority die (with Su(z)2^1.b7)

(Emmons et al., 2009)

partially lethal - majority die (with Su(z)2^s15)

(Emmons et al., 2009)

partially lethal - majority die (with Su(z)2^s84)

(Emmons et al., 2009)

partially lethal - majority die (with Su(z)2^s95)

(Emmons et al., 2009)

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

(Doheny et al., 2008)

viable

(Wu and Howe, 1995)

viable (with Su(z)2^s20)

(Emmons et al., 2009)

viable (with Su(z)2^s21)

(Emmons et al., 2009)

viable (with Su(z)2^s36)

(Emmons et al., 2009)

viable (with Su(z)2^sM)

(Emmons et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

One copy of Su(z)2^e26 is unable to suppress position effect variegation (PEV) at the w locus caused by In(1)w^m4.

One copy of Su(z)2^e26 weakly suppresses the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

(Doheny et al., 2008)

Suppresses z¹ eye color.

(Wu and Howe, 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Su(z)2^sM

(Emmons et al., 2009)

Su(z)2^s36

(Emmons et al., 2009)

Su(z)2^s21

(Emmons et al., 2009)

Su(z)2^s20

(Emmons et al., 2009)

Partially complements

Su(z)2^s95

(Emmons et al., 2009)

Su(z)2^s84

(Emmons et al., 2009)

Su(z)2^s15

(Emmons et al., 2009)

Su(z)2^1.b7

(Emmons et al., 2009)

Fails to complement

Su(z)2^4-34

(Emmons et al., 2009)

Su(z)2^4-31

(Emmons et al., 2009)

Su(z)2¹

(Emmons et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Complementation behavior is complex: this allele is only tentatively assigned to Su(z)3.

(Wu and Howe, 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Su(z)2^De26

(Doheny et al., 2008)

Su(z)2^e26

Su(z)2D^e26

(Emmons et al., 2009)

Su(z)2De²⁶

(Doheny et al., 2008)

Su(z)3^e26

e26

(Nguyen et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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