FlyBase Allele Report: Dmel\br[1]

General Information

Symbol

Dmel\br¹

Species

D. melanogaster

Name

FlyBase ID

FBal0001189

Feature type

allele

Associated gene

Dmel\br

Associated Insertion(s)

412{}br¹

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Restifo and Merrill, 1994, Gotwals and Fristrom, 1991, Sampedro et al., 1989, Demakova et al., 1988, Belyaeva et al., 1982, Belyaeva et al., 1980)

Mutagen

spontaneous

(Restifo and Merrill, 1994, Gotwals and Fristrom, 1991, Sampedro et al., 1989, Kiss et al., 1988)

Progenitor genotype

Associated Insertion(s)

412{}br¹

Cytology

Description

412 element insertion at 164.4 kb.

(Sampedro et al., 1989)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | second instar larval stage

(Parrish et al., 2009)

female fertile

(Galceran et al., 1990)

male fertile

(Galceran et al., 1990)

viable

(Wilson et al., 2006, Chen et al., 2004, Tzolovsky et al., 1999, Restifo and Merrill, 1994, Galceran et al., 1990, Demakova et al., 1988)

visible | heat sensitive

(Gotwals and Fristrom, 1991)

Phenotype Manifest In

adult brain

(Restifo and White, 1991)

adult optic lobe

(Restifo and White, 1991)

dorsal appendage (with br^A47)

(Tzolovsky et al., 1999, Deng and Bownes, 1997)

dorsal appendage (with br^npr-6)

(Tzolovsky et al., 1999, Deng and Bownes, 1997)

dorsal appendage (with br^rbp-1)

(Tzolovsky et al., 1999)

embryonic/larval proventriculus | embryonic stage

(Restifo and White, 1992)

embryonic/larval salivary gland | embryonic stage

(Restifo and White, 1992)

indirect flight muscle cell

(Restifo and White, 1992)

leg

(Chen et al., 2004)

maxillary palp

(Restifo and Merrill, 1994)

maxillary palpus & macrochaeta

(Restifo and Merrill, 1994)

ovary

(Wilson et al., 2006)

rostral membrane

(Restifo and Merrill, 1994)

wing

(Gotwals and Fristrom, 1991, Demakova et al., 1988, Belyaeva et al., 1980)

Detailed Description

Statement

Reference

br¹ mutants persist as third instar larvae for days or even weeks.

(Parrish et al., 2009)

br¹ females show slightly reduced levels of oviposition compared to wild-type females. The susceptibility of br¹ flies to methoprene is not significantly different from wild-type flies.

(Wilson et al., 2006)

1% of hemizygous males have a malformed leg phenotype.

(Chen et al., 2004)

Hemizygous males and homozygous females maintained at 21^oC have malformed legs at a low frequency (0.4%).

(Ward et al., 2003)

The br¹/br^npr-6 and br¹/br^A47 mothers produce eggs that have reduced dorsal appendages. br¹/br⁵ and br¹/br⁶ females produce eggs that have normal dorsal appendages. br¹/br^rbp-1 mothers produce eggs that have reduced dorsal appendages, similar to the phenotype seen in br¹/br^A47 mothers.

(Tzolovsky et al., 1999)

Female progeny br^A47/br¹ survive until adulthood and produce eggs with reduced dorsal appendages. Normal embryos develop that successfully hatch into larvae. Female progeny br^npr-6/br¹ survive until adulthood and produce eggs with reduced dorsal appendages.

(Deng and Bownes, 1997)

Viable allele.

(Emery et al., 1994)

Heterozygotes with br^npr-7 display small maxillary palps that are virtually devoid of mechanosensory bristles. Rostral membrane is lost so the proboscis is barely visible.

(Restifo and Merrill, 1994)

Failure of salivary gland degeneration. Reduction in dorso-ventral class of indirect flight muscles. Some show proventriculus abnormality: foregut-midgut junction less proventriculus-like in appearance.

(Restifo and White, 1992)

Homozygote br¹ wings are shorter and wider than wild type. The phenotype of br¹ homozygotes is intensified when placed in trans with br^npr-3 resulting in the mlf syndrome. zip interacts with br¹ hemizygous males.

(Gotwals and Fristrom, 1991)

41% penetrance of abnormal SEG-TG separation phenotype, 55% of individuals show an abnormal optic lobe position and 35% a brain fusion failure.

(Restifo and White, 1991)

Heterozygotes with Df(1)RA19 are partially viable at 29^oC, survivors have either short or faded wings.

(Belyaeva et al., 1982)

Heterozygotes with Df(1)br²⁵ have normal viability and br wings.

(Belyaeva et al., 1980)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

br¹ has visible | dominant phenotype, enhanceable by LIMK1^D522A.UAS/Scer\GAL4^hs.PB

(Chen et al., 2004)

br¹ has visible | dominant phenotype, enhanceable by Rho1[+]/Rho1^k02107b

(Chen et al., 2004)

br¹ has visible | dominant phenotype, enhanceable by zip[+]/zip^Ebr

(Chen et al., 2004)

br¹ has visible | dominant phenotype, enhanceable by Rho1^72O/Rho1[+]

(Chen et al., 2004)

br¹ has visible phenotype, enhanceable by Df(3L)Scf-R6/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3L)Ten-m-AL29/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by +/Df(3L)XS2182

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3L)XS533/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3L)XS543/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3L)XS572/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by +/Df(3L)brm11

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3L)fz-M21/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3L)kto2/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3L)lxd6/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3R)3450/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3R)D6/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3R)D7/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3R)DG2/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by +/Df(3R)Delta-BX12

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3R)H-B79/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by +/Df(3R)L127

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3R)M-Kx1/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3R)ME15/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3R)RD31/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3R)ea/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3R)mbc-30/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3R)mbc-R1/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3R)p25/Df(3R)P2

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3R)p712/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by E(br)121^Ebr121/E(br)121[+]

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by E(br)155[+]/Mcr¹

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by E(br)160[+]/E(br)160^Ebr160

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by E(br)165[+]/Sec61α^Ebr165

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by E(br)187^Ebr187/E(br)187[+]

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Rho1[+]/Rho1^k02107b

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by E(br)24[+]/E(br)24^Ebr24

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by E(br)333[+]/E(br)333^Ebr333

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by E(br)420[+]/E(br)420^Ebr420

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by E(br)444[+]/E(br)444^Ebr444

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by E(br)65^Ebr65/E(br)65[+]

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by E(br)72^Ebr72/E(br)72[+]

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by In(2LR)DTD116^LDTD24^R/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by In(2LR)DTD16^LDTD42^R/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Rho1^E3.10/Rho1[+]

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Rho1^Ebr233/Rho1[+]

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Rho1[+]/Rho1^Ebr246

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Rho1^J3.8/Rho1[+]

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Sb[+]/Sb^Ebr20

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Sb[+]/Sb^Ebr228

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Sb[+]/Sb^Ebr448

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Sb[+]/Sb^Ebr48

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Sb[+]/Sb^Ebr536

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Sb^Ebr623/Sb[+]

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Tm1[+]/Tm1⁰²²⁹⁹

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Tm1[+]/Tm1^eg9

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by bs[+]/bs^Ebr292

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by bs⁰³²⁶⁷/bs[+]

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by bs[+]/bs^k07909

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2L)ast2/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2L)N22-14/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2L)TW3/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2L)TW50/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2L)VA12/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2L)VA18/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2L)cl-h3/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2L)pr-A14/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2L)pr-A16/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)CX1/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)H3E1/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)Jp1/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by +/Df(2R)Jp4

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)Jp5/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)Jp7/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)Jp8/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)Kr10/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by +/Df(2R)M41A4

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)Np3/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)Np4/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)Np5/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)P34/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)Pcl11B/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)Pcl7B/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by +/Df(2R)Px1

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)Px2/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)RM2-1/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)ST1/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)X58-12/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)X58-8/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(2R)vg-C/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3L)66C-G28/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3L)81k19/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by +/Df(3L)Brd6

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3L)GN24/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3L)HR119/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3L)HR218/+

(Ward et al., 2003)

br¹ has visible phenotype, enhanceable by Df(3L)R-G7/+

(Ward et al., 2003)

NOT Enhanced by

Statement

Reference

br¹ has visible | dominant phenotype, non-enhanceable by Rac1^J11/Rac1[+]

(Chen et al., 2004)

br¹ has visible | dominant phenotype, non-enhanceable by Rac2³¹⁴/Rac2[+]

(Chen et al., 2004)

br¹ has visible phenotype, non-enhanceable by Tm1^er4/Tm1[+]

(Ward et al., 2003)

br¹ has visible phenotype, non-enhanceable by Tm2³/Tm2[+]

(Ward et al., 2003)

br¹ has visible phenotype, non-enhanceable by bs[+]/bs^ba

(Ward et al., 2003)

NOT suppressed by

Statement

Reference

br¹ has visible phenotype, non-suppressible by bs[+]/bs^ba

(Ward et al., 2003)

Enhancer of

Statement

Reference

br¹ is an enhancer of visible phenotype of LIMK1^D522A.UAS, Scer\GAL4^hs.PB

(Chen et al., 2004)

NOT Suppressor of

Statement

Reference

br¹/br¹ is a non-suppressor of chemical sensitive phenotype of Met³

(Wilson et al., 2006)

Other

Statement

Reference

Met¹²⁸, br¹ has some die during P-stage phenotype

(Wilson et al., 2006)

Met²⁵³, br¹ has some die during P-stage phenotype

(Wilson et al., 2006)

Met²⁷, br¹ has lethal - all die during P-stage phenotype

(Wilson et al., 2006)

Met^A3, br¹ has lethal - all die during P-stage phenotype

(Wilson et al., 2006)

Met^W3, br¹ has lethal - all die during P-stage phenotype

(Wilson et al., 2006)

Met¹²⁸, br^rbp-1/br¹ has lethal phenotype

(Wilson et al., 2006)

Met²⁷, br⁵/br¹ has lethal - all die during P-stage phenotype

(Wilson et al., 2006)

Met²⁷, br¹/br^2Bc-1 has viable phenotype

(Wilson et al., 2006)

Met²⁷, br¹ has lethal phenotype

(Wilson et al., 2006)

Rho1^E3.10, br¹ has visible | cold sensitive phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], br¹ has visible | cold sensitive phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], br¹ has visible | cold sensitive phenotype

(Bayer et al., 2003)

Rho1^J3.8, br¹ has visible | cold sensitive phenotype

(Bayer et al., 2003)

Df(2R)Jp1/+, br¹ has visible phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, br¹ has visible phenotype

(Bayer et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

br¹ has ovary phenotype, enhanceable by Met²⁷/Met²⁷

(Wilson et al., 2006)

br¹ has ovary phenotype, enhanceable by Met¹²⁸/Met¹²⁸

(Wilson et al., 2006)

br¹ has ovary phenotype, enhanceable by Met²⁵³/Met²⁵³

(Wilson et al., 2006)

br¹ has ovary phenotype, enhanceable by Met³/Met³

(Wilson et al., 2006)

br¹ has ovary phenotype, enhanceable by Met^A3/Met^A3

(Wilson et al., 2006)

br¹ has ovary phenotype, enhanceable by Met^D29/Met^D29

(Wilson et al., 2006)

br¹ has ovary phenotype, enhanceable by Met^W3/Met^W3

(Wilson et al., 2006)

br¹ has leg phenotype, enhanceable by LIMK1^D522A.UAS/Scer\GAL4^hs.PB

(Chen et al., 2004)

br¹ has leg phenotype, enhanceable by Rho1[+]/Rho1^k02107b

(Chen et al., 2004, Ward et al., 2003)

br¹ has leg phenotype, enhanceable by zip[+]/zip^Ebr

(Chen et al., 2004)

br¹ has leg phenotype, enhanceable by Rho1^72O/Rho1[+]

(Chen et al., 2004)

br¹ has leg phenotype, enhanceable by Df(3L)Scf-R6/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3L)Ten-m-AL29/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by +/Df(3L)XS2182

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3L)XS533/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3L)XS543/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3L)XS572/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by +/Df(3L)brm11

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3L)fz-M21/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3L)kto2/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3L)lxd6/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3R)3450/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3R)D6/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3R)D7/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3R)DG2/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by +/Df(3R)Delta-BX12

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3R)H-B79/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by +/Df(3R)L127

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3R)M-Kx1/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3R)ME15/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3R)RD31/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3R)ea/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3R)mbc-30/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3R)mbc-R1/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3R)p25/Df(3R)P2

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3R)p712/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by E(br)121^Ebr121/E(br)121[+]

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by E(br)155[+]/Mcr¹

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by E(br)160[+]/E(br)160^Ebr160

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by E(br)165[+]/Sec61α^Ebr165

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by E(br)187^Ebr187/E(br)187[+]

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by E(br)24[+]/E(br)24^Ebr24

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by E(br)333[+]/E(br)333^Ebr333

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by E(br)420[+]/E(br)420^Ebr420

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by E(br)444[+]/E(br)444^Ebr444

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by E(br)65^Ebr65/E(br)65[+]

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by E(br)72^Ebr72/E(br)72[+]

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by In(2LR)DTD116^LDTD24^R/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by In(2LR)DTD16^LDTD42^R/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Rho1^E3.10/Rho1[+]

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Rho1^Ebr233/Rho1[+]

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Rho1[+]/Rho1^Ebr246

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Rho1^J3.8/Rho1[+]

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Sb[+]/Sb^Ebr20

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Sb[+]/Sb^Ebr228

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Sb[+]/Sb^Ebr448

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Sb[+]/Sb^Ebr48

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Sb[+]/Sb^Ebr536

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Sb^Ebr623/Sb[+]

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Tm1[+]/Tm1⁰²²⁹⁹

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Tm1[+]/Tm1^eg9

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by bs[+]/bs^Ebr292

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by bs⁰³²⁶⁷/bs[+]

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by bs[+]/bs^k07909

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2L)ast2/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2L)N22-14/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2L)TW3/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2L)TW50/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2L)VA12/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2L)VA18/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2L)cl-h3/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2L)pr-A14/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2L)pr-A16/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)CX1/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)H3E1/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)Jp1/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by +/Df(2R)Jp4

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)Jp5/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)Jp7/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)Jp8/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)Kr10/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by +/Df(2R)M41A4

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)Np3/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)Np4/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)Np5/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)P34/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)Pcl11B/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)Pcl7B/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by +/Df(2R)Px1

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)Px2/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)RM2-1/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)ST1/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)X58-12/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)X58-8/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(2R)vg-C/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3L)66C-G28/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3L)81k19/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by +/Df(3L)Brd6

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3L)GN24/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3L)HR119/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3L)HR218/+

(Ward et al., 2003)

br¹ has leg phenotype, enhanceable by Df(3L)R-G7/+

(Ward et al., 2003)

NOT Enhanced by

Statement

Reference

br¹ has ovary phenotype, non-enhanceable by Met^E1/Met^E1

(Wilson et al., 2006)

br¹ has leg phenotype, non-enhanceable by Rac1^J11/Rac1[+]

(Chen et al., 2004)

br¹ has leg phenotype, non-enhanceable by Rac2³¹⁴/Rac2[+]

(Chen et al., 2004)

br¹ has leg phenotype, non-enhanceable by Tm1^er4/Tm1[+]

(Ward et al., 2003)

br¹ has leg phenotype, non-enhanceable by Tm2³/Tm2[+]

(Ward et al., 2003)

br¹ has leg phenotype, non-enhanceable by bs[+]/bs^ba

(Ward et al., 2003)

NOT suppressed by

Statement

Reference

br¹ has leg phenotype, non-suppressible by bs[+]/bs^ba

(Ward et al., 2003)

br¹ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

br¹/br¹ is an enhancer of ovary phenotype of Met²⁷

(Wilson et al., 2006)

br¹ is an enhancer of leg phenotype of LIMK1^D522A.UAS, Scer\GAL4^hs.PB

(Chen et al., 2004)

Other

Statement

Reference

Rho1^E3.10, br¹ has leg | cold sensitive phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, br¹ has leg phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], br¹ has leg | cold sensitive phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], br¹ has leg | cold sensitive phenotype

(Bayer et al., 2003)

Rho1^J3.8, br¹ has leg | cold sensitive phenotype

(Bayer et al., 2003)

Df(2R)Jp1/+, br¹ has leg phenotype

(Bayer et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

br¹/br¹, Rst(1)JH²⁷/Rst(1)JH²⁷ mutants are lethal in both pupal and especially pharate adult stages, but small numbers of escaper adults eclose. When these mutants express the Rst(1)JH^+tSt-H.hs transgene, they survive to adulthood. 54% of br⁵/br¹, Rst(1)JH²⁷/+ mutants survive to adulthood but br⁵/br¹, Rst(1)JH²⁷/Rst(1)JH²⁷ mutants are lethal in prepupal/early pupal development. br¹, Rst(1)JH³/Y, br¹, Rst(1)JH^E1/Y and br¹, Rst(1)JH^D29/Y hemizygotes show good levels of survival. br¹, Rst(1)JH³ flies show the same sensitivity to methoprene as br¹ single mutant flies. br¹, Rst(1)JH²⁷ female escapers show strong reductions in oogenesis. The following double mutant escapers show significantly reduced levels of oogenesis compared to br¹ single mutants: br¹, Rst(1)JH^A3; br¹, Rst(1)JH¹²⁸; br¹, Rst(1)JH^W3; br¹, Rst(1)JH^D29; br¹, Rst(1)JH³ and br¹, Rst(1)JH²⁵³.

(Wilson et al., 2006)

The expressivity of the defective eye phenotype seen in Met^W3 and Met²⁷ flies is not increased by br¹.

(Wilson et al., 2006)

The frequency of the malformed leg phenotype seen in br¹/Y males (1%) is increased if the flies are also heterozygous for Rho1^72O (12%), Rho1^k02107b (55%) or zip^Ebr (56%). The frequency of the malformed leg phenotype seen in br¹/Y males (1%) is not increased if the flies are also heterozygous for Rac1^J11/+ (0%) or Rac2³¹⁴/+ (2%). Expression of LIMK1^{D522A.Scer\UAS} under the control of Scer\GAL4^hs.PB enhances the frequency of the malformed leg phenotype seen in br¹/Y males from 1% to 36%.

(Chen et al., 2004)

br¹ fails to show a significant genetic interaction (assayed in terms of a malformed leg phenotype) with RhoGEF2^1.1, RhoGEF2^4.1, RhoGEF2⁰⁴²⁹¹, RhoGEF2^11-3, E(zip)12-5^12-5, Rho1^12-6, E(zip)18-5^18-5, E(zip)31-6^31-6 or zip^33-1.

(Bayer et al., 2003)

At 18^oC, 73% of br¹/Y ; bs⁰³²⁶⁷/+ animals have malformed legs, at 21^oC, the frequency of malformed legs is 15%. At 18^oC, 30% of br¹/Y ; bs^k07909/+ animals have malformed legs, at 21^oC, the frequency of malformed legs is 9%.