dmPI31
Please see the JBrowse view of Dmel\PI31 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.42
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
The Hydrophobic-Tyrosine-X (HbYX) motif is involved in proteasome activation.
Interacts with ntc. Interacts with Tnks (via ANK repeats). Interacts with 20S proteasome subunits Prosalpha1, Prosalpha3, Prosalpha4 and Prosalpha6, but not with Prosalpha2 and Prosalpha5. The interaction with Prosalpha4 is reduced by PI31 ADP-ribosylation. Interacts with the 19S assembly chaperones PSMD5 and PSMD9; these interactions are increased by PI31 ADP-ribosylation.
ADP-ribosylation by Tnks increases its affinity for assembly chaperones PSMD9 and PMSD5, sequestering them away from the proteasome Rpt base subunits and promoting in this way 26S proteasome assembly. Also interferes with its inhibitory effect on 20S proteasome.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PI31 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
PI31 protein is localized at the base of the elongated nuclei and in a circular pattern around the actin cones during the process of spermatid individualization.
JBrowse - Visual display of RNA-Seq signals
View Dmel\PI31 in JBrowse2-65
2-66.3
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: PI31 CG8979