FlyBase Gene Report: Dmel\Sod2

FB2024_02 , released April 23, 2024

FB2024_02 , released April 23, 2024

Gene: Dmel\Sod2

General Information

Symbol

Dmel\Sod2

Species

D. melanogaster

Name

Superoxide dismutase 2 (Mn)

Annotation Symbol

CG8905

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010213

Gene Model Status

Stock Availability

17 publicly available

Enzyme Name (EC)

superoxide dismutase (1.15.1.1)

Gene Summary

Superoxide dismutase 2 (Mn) (Sod2) encodes an enzyme that detoxifies superoxide radicals in mitochondria. The loss of Sod2 generates endogenous oxidative stress that results in reduced activity of critical mitochondrial enzymes, hypersensitivity to oxidative stress and neonatal lethality. A muscle restricted p38Kinase-Mef2-Sod2 signaling module influences life span and stress. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

MnSOD, SOD, Mn-SOD, Mn SOD, superoxide dismutase 2

Key Links

Genomic Location

Cytogenetic map

Sequence location

2R:16,772,785..16,773,915 [-]

Recombination map

2-80

RefSeq locus

NT_033778 REGION:16772785..16773915

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables antioxidant activity

non-traceable author statement

(Helfand and Rogina, 2003)

enables manganese ion binding

inferred from biological aspect of ancestor with PANTHER:PTN004256454

(GO Reference Genome Project, 2011-)

enables metal ion binding

inferred from electronic annotation with InterPro:IPR001189, InterPro:IPR019831, InterPro:IPR019832, InterPro:IPR019833

(InterPro Project Members, 2004-)

enables superoxide dismutase activity

inferred from biological aspect of ancestor with PANTHER:PTN004256454

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:P04179

(Sardiello et al., 2003.6.11)

inferred from electronic annotation with InterPro:IPR001189, InterPro:IPR019831, InterPro:IPR019832, InterPro:IPR019833

(InterPro Project Members, 2004-)

Biological Process (10 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

involved_in determination of adult lifespan

inferred from mutant phenotype

(Curtis et al., 2007, Mockett et al., 1999)

involved_in heart morphogenesis

inferred from mutant phenotype

(Lim et al., 2014)

involved_in paracrine signaling

inferred from mutant phenotype

(Lim et al., 2014)

involved_in reactive oxygen species metabolic process

inferred from mutant phenotype

(Lim et al., 2014)

involved_in regulation of autophagy of mitochondrion

inferred from genetic interaction with FLYBASE:park; FB:FBgn0041100

(Bhandari et al., 2014)

involved_in regulation of hemocyte proliferation

inferred from mutant phenotype

(Sinenko et al., 2010)

involved_in regulation of metabolic process

inferred from mutant phenotype

(Curtis et al., 2007)

involved_in regulation of synaptic plasticity

inferred from mutant phenotype

(Oswald et al., 2018)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in determination of adult lifespan

traceable author statement

(Helfand and Rogina, 2003)

involved_in removal of superoxide radicals

inferred from sequence or structural similarity with UniProtKB:P04179

(Sardiello et al., 2003.6.11)

involved_in superoxide metabolic process

inferred from electronic annotation with InterPro:IPR001189, InterPro:IPR019831, InterPro:IPR019832, InterPro:IPR019833

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in mitochondrial matrix

inferred from sequence or structural similarity with UniProtKB:P04179

(Sardiello et al., 2003.6.11)

is_active_in mitochondrion

inferred from biological aspect of ancestor with PANTHER:PTN000150076

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

SUPEROXIDE DISMUTASES

Protein Family (UniProt)

Belongs to the iron/manganese superoxide dismutase family. (Q00637)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

superoxide dismutase activity

2 H(+) + 2 superoxide = H2O2 + O2 (1.15.1.1)

RHEA 20696:

Summaries

Gene Snapshot

Superoxide dismutase 2 (Mn) (Sod2) encodes an enzyme that detoxifies superoxide radicals in mitochondria. The loss of Sod2 generates endogenous oxidative stress that results in reduced activity of critical mitochondrial enzymes, hypersensitivity to oxidative stress and neonatal lethality. A muscle restricted p38Kinase-Mef2-Sod2 signaling module influences life span and stress. [Date last reviewed: 2019-09-26]

Gene Group (FlyBase)

SUPEROXIDE DISMUTASES -: Superoxide dismutase enzymes catalyze the breakdown of superoxide into hydrogen peroxide and water and are therefore central regulators of reactive oxygen species levels. (Adapted from FBrf0184132.)

Protein Function (UniProtKB)

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

(UniProt, Q00637)

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\Sod2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q00637)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0087078

884

217

FBtr0345492

1015

217

Additional Transcript Data and Comments

Reported size (kB)

0.8 (longest cDNA)

(Duttaroy et al., 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0086226

24.7

217

8.10

FBpp0311603

24.7

217

8.10

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

217 aa isoforms: Sod2-PA, Sod2-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

217 (aa)

(Duttaroy et al., 1994)

Comments

External Data

Subunit Structure (UniProtKB)

Homotetramer.

(UniProt, Q00637)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sod2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sod2_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.10

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

(Blackney et al., 2014)

adult stage | female

(Blackney et al., 2014)

day 1 of adulthood -- day 5 of adulthood

(Paul and Duttaroy, 2003)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

day 5 of adulthood & male -- day 7 of adulthood & male

(Wasbrough et al., 2010)

day 7 of adulthood -- day 49 of adulthood

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sod2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Sod2

View exonic expression by tissue for Dmel\Sod2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010213

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36878/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010213

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010213

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010213

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8905

Flygut - An atlas of the Drosophila adult midgut

FBgn0010213

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 20 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Sod2

Transgenic constructs containing regulatory region of Sod2

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

(Belton et al., 2006, Ryder, 2004.4.26)

(Celotto et al., 2012, Belton et al., 2006, Ryder, 2004.4.26)

(Belton et al., 2006)

Gene partially disrupted in

(Belton et al., 2006)

Gene not disrupted in

(Belton et al., 2006)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Sod2^GD14064

lethal (with Df(2R)Exel7145)

Sod2^{CR00559-TG4.2}

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Sod2^GD14064

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

Sod2^GD14064

Sod2^KG06854

viable, with Scer\GAL4^pnr-MD237

Sod2^GD14064

viable, with Scer\GAL4^tin.CΔ4

Sod2^GD14064

Sterility

Allele

Sod2^KG06854

Other Phenotypes

Allele

abnormal behavior | adult stage

Sod2ⁿ²⁸³

abnormal locomotor behavior | adult stage

Sod2ⁿ²⁸³

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^elav.PLu

Sod2^UAS.cMa

abnormal locomotor behavior | larval stage, with Scer\GAL4^C57

Sod2^HMS00499

abnormal neuroanatomy | adult stage (with Df(2R)Exel7145)

Sod2^bwd

abnormal neuroanatomy | dominant | third instar larval stage

Sod2^bwd

abnormal neuroanatomy | third instar larval stage (with Df(2R)Exel7145)

Sod2^bwd

abnormal oxidative stress response, with Scer\GAL4^Ugt36A1.PK

Sod2^UAS.cMa

abnormal smell perception | adult stage

Sod2ⁿ²⁸³

abnormal smell perception | progressive (with Sod2^KG06854)

Sod2ⁿ²⁸³

abnormal smell perception | progressive (with Sod2ⁿ²⁸³)

Sod2^KG06854

abnormal stress response | adult stage, with Scer\GAL4^rn-GAL4-5

Sod2^UAS.cMa

abnormal stress response | dominant

Sod2ⁿ²⁸³

bang sensitive (with Sod2^KG06854)

Sod2ⁿ²⁸³

bang sensitive (with Sod2ⁿ²⁸³)

Sod2^KG06854

bang sensitive | progressive (with Df(2R)Exel7145)

Sod2^bwd

bang sensitive | recessive

Sod2^bwd

chemical sensitive | dominant

Sod2ⁿ²⁸³

decreased cell number | third instar larval stage | conditional, with Scer\GAL4^Antp-10

Sod2^UAS.cMa

increased cell death | adult stage

Sod2ⁿ²⁸³

Sod2^Act5C.PS

long lived, with Scer\GAL4^da.PU

Sod2^UAS.cUa

long lived, with Tn10\tetR^rtTA.Act5C

Sod2^tetO.cCa

short lived, with Scer\GAL4^da.G32

Sod2^RNAi.UAS.cKa

short lived, with Scer\GAL4^da.PU

Sod2^RNAi.UAS.cKa

short lived (with Df(2R)Exel6064)

short lived (with Df(2R)Exel7145)

short lived (with Df(2R)Sod2-332)

Sod2ⁿ²⁸³

short lived (with Sod2¹¹)

Sod2ⁿ²⁸³

short lived (with Sod2^KG06854)

Sod2ⁿ²⁸³

short lived (with Sod2ⁿ²⁸³)

short lived | dominant

Sod2ⁿ²⁸³

short lived | heat sensitive, with Tn10\tetR^rtTA.Act5C

Sod2^tetO.cCa

short lived | recessive

Sod2ⁿ²⁸³

short lived | tetracycline conditional, with Tn10\tetR^rtTA.Act5C

Sod2^tetO.cFa

some die during immature adult stage | recessive

Sod2ⁿ²⁸³

visible | adult stage, with Scer\GAL4^rn-GAL4-5

Sod2^UAS.cMa

Phenotype manifest in

Allele

Sod2ⁿ²⁸³

adult brain (with Df(2R)Exel7145)

Sod2^bwd

adult fat body | adult stage, with Scer\GAL4^ppl.PU

Sod2^RNAi.UAS.cUa

Sod2ⁿ²⁸³

adult heart, with Scer\GAL4^Ugt36A1.PK

Sod2^UAS.cMa

embryonic/larval motor neuron | third instar larval stage

Sod2^bwd

embryonic/larval motor neuron | third instar larval stage (with Df(2R)Exel7145)

Sod2^bwd

lamellocyte | third instar larval stage | conditional, with Scer\GAL4^Antp-10

Sod2^UAS.cMa

lipid droplet | adult stage, with Scer\GAL4^ppl.PU

Sod2^RNAi.UAS.cUa

sarcomere, with Scer\GAL4^Mef2.PR

Sod2^GD14064

wing, with Scer\GAL4^rn-GAL4-5

Sod2^UAS.cMa

Z disc, with Scer\GAL4^Mef2.PR

Sod2^GD14064

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

14 of 14

Yes

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

14 of 14

Yes

Yes

Mus musculus (laboratory mouse) (1)

13 of 14

Yes

Yes

Xenopus tropicalis (Western clawed frog) (2)

7 of 13

Yes

Yes

1 of 13

No

No

Danio rerio (Zebrafish) (1)

14 of 14

Yes

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

14 of 14

Yes

Yes

14 of 14

Yes

Yes

Anopheles gambiae (African malaria mosquito) (1)

12 of 12

Yes

Yes

Arabidopsis thaliana (thale-cress) (6)

13 of 13

Yes

Yes

12 of 13

No

Yes

5 of 13

No

Yes

5 of 13

No

Yes

4 of 13

No

Yes

1 of 13

No

Yes

Saccharomyces cerevisiae (Brewer's yeast) (3)

12 of 13

Yes

Yes

2 of 13

No

Yes

2 of 13

No

Yes

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\SPAC1486.01

11 of 12

Yes

Yes

Spom\SPBC3H7.04

2 of 12

No

Yes

Spom\SPBC16A3.14

2 of 12

No

Yes

Escherichia coli (enterobacterium) (2)

8 of 11

Yes

Yes

5 of 11

No

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Sod2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 6 )

Allele

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by park²⁵

(Vincent et al., 2012)

ameliorates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Dias-Santagata et al., 2007)

exacerbates neurodegenerative disease

modeled by Zzzz\CAG^{Q48.UAS.Tag:MYC,Tag:FLAG}

(Underwood et al., 2010)

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Rival et al., 2009)

ameliorates acute myeloid leukemia

modeled by Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

(Sinenko et al., 2010)

ameliorates autosomal dominant cerebellar ataxia

modeled by tws^UAS.cBa

(Wang et al., 2011)

ameliorates cardiomyopathy

modeled by park^HMS01651

(Bhandari et al., 2014)

modeled by park^HMS01800

(Bhandari et al., 2014)

ameliorates intestinal cancer

modeled by N^RNAi.P.UAS

(Chen et al., 2021)

exacerbates mucopolysaccharidosis type IIIA

modeled by Sgsh^GD1578

(Webber et al., 2018)

Sod2^RNAi.UAS.cKa

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^Aβ42.lexAop

(Stapper and Jahn, 2018)

exacerbates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Dias-Santagata et al., 2007)

modeled by Hsap\MAPT^E14.UAS

(Dias-Santagata et al., 2007)

ameliorates amyotrophic lateral sclerosis type 8

modeled by Vap33^P58S.cRa.UAS

(Chaplot et al., 2019)

exacerbates intestinal cancer

modeled by N^RNAi.P.UAS

(Chen et al., 2021)

exacerbates atypical teratoid rhabdoid tumor

modeled by Snr1^KK101602

(Tegeder et al., 2019)

ameliorates Parkinson's disease

modeled by Pink1^B9

(Koh et al., 2012)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SOD2; superoxide dismutase 2

14 of 14

MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 6; MVCD6

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

On

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

MIST Molecular Interaction Search Tool

View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Wang et al., 2021)

enhanceable

(Itsara et al., 2014)

enhanceable

(Lim et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Yoon et al., 2019)

suppressible

(Tegeder et al., 2019)

enhanceable

(Burbridge et al., 2021)

suppressible

(Miozzo et al., 2022)

suppressible

(Reitman et al., 2015)

enhanceable

(Choo et al., 2015)

suppressible

(Choo et al., 2015)

suppressible

(Sinenko et al., 2011)

suppressible

(Vrailas-Mortimer et al., 2011)

suppressible

(Vrailas-Mortimer et al., 2011)

suppressible

(Bhandari et al., 2014, Vincent et al., 2012)

suppressible

(Koh et al., 2012)

suppressible

(Clemente-Ruiz et al., 2016)

suppressible

(Na et al., 2014)

enhanceable

(Webber et al., 2018)

suppressible

(Gururaja Rao et al., 2019)

suppressible

(Tegeder et al., 2019)

enhanceable

(Lim et al., 2014)

suppressible

(Muliyil et al., 2020)

suppressible

(Vaccaro et al., 2020)

suppressible

(Wang et al., 2011)

suppressible

(Qi et al., 2016)

External Data

Subunit Structure (UniProtKB)

Homotetramer.

(UniProt, Q00637 )

Linkouts

BioGRID - A database of protein and genetic interactions.

62587

DroID - A comprehensive database of gene and protein interactions.

FBgn0010213

MIST (genetic) - An integrated Molecular Interaction Database

36878

MIST (protein-protein) - An integrated Molecular Interaction Database

36878

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Detoxification of Reactive Oxygen Species

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2R

Recombination map

2-80

Cytogenetic map

Sequence location

2R:16,772,785..16,773,915 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

53D8-53D8

Limits computationally determined from genome sequence between P{PZ}Sema-2a⁰³⁰²¹&P{PZ}Cdk4⁰⁵⁴²⁸ and P{EP}BEST:SD02913^EP2148&P{lacW}Dek^k09907

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

53E1-53E4

(determined by in situ hybridisation)

(Duttaroy et al., 1997)

Experimentally Determined Recombination Data

Location

2-80

(FlyBase, 2016)

2-84.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (17)

Aberrations including deletions of this gene Aberrations including duplications of this gene

24494

w¹; P{UAS-Sod2.M}UM83

24489

w¹; P{UAS-Sod2.RNAi.K}15/SM5

25969

y¹ v¹; P{TRiP.JF01989}attP2

27643

y¹ w^*; Sod2^Δ02/CyO

27644

y¹ w^*; Sod2^Δ12/CyO

14052

y¹ w^67c23; P{SUPor-P}Sod2^KG06854

27645

P{UAS-Sod2.Z}1B, y¹ w^*; Sod2^Δ02/CyO

80593

y¹ w^*; TI{CRIMIC.TG4.2}Sod2^{CR00559-TG4.2}/CyO

34060

w^*; Sod2ⁿ²⁸³/CyO, P{GAL4-twi.G}2.2, P{UAS-2xEGFP}AH2.2

77204

y¹ sc^* v¹ sev²¹; P{TKO.GS00733}attP40

v110547

P{KK108954}VIE-260B

v42162

w¹¹¹⁸; P{GD14064}v42162

More stocks available...

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (82)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH02759

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010213

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010213

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Overexpression of Sod2 results in an increase in life span in proportion to the increase in Sod2 enzyme activity.

(Sun et al., 2002)

Area matching Drosophila manganese superoxide dismutase gene, Acc. No. L34276.

(Davies, 2001.3.15)

There appears to be an optimal level of Sod2 activity which minimzes oxidative stress. The naturally evolved level appears to be near the optimal required under normal conditions, although the optimum may be shifted to a higher level under more stressful conditions.

(Mockett et al., 1999)

Structure and expression of Sod2 is studied.

(Duttaroy et al., 1997)

Expression of Sod2 is reduced in rl¹ mutants, suggesting a role of the rl encoded MAP-kinase in regulating Sod2.

(Duttaroy et al., 1997)

A Sod2 cDNA has been cloned and sequenced.

(Duttaroy et al., 1994)

Phylogenetic trees for 25 Cu-Zn superoxide dismutases (including D.melanogaster Sod and Dvir\Sod) and 31 Mn/Fe superoxide dismutases (including D.melanogaster Sod2) have been constructed and the evolutionary rate of change for the two groups of proteins has been compared.

(Smith and Doolittle, 1992)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (42)

Reported As

Symbol Synonym

CG8905

(Baron et al., 2016, Çiçek et al., 2016, Choo et al., 2015, Hosono et al., 2015, Kim et al., 2015, Rovenko et al., 2015, Faust et al., 2012, Mandilaras and Missirlis, 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Terhzaz et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, Landis and Tower, 2005, Kang et al., 2002)

MN-SOD

(Shevchuk et al., 2023)

Mito SOD

(Terhzaz et al., 2010)

Mn SOD

(Peng et al., 2009, Clark et al., 2006, Boulianne, 2001, Clancy et al., 2001, Le Bourg, 2001, Mockett et al., 1999, Mockett et al., 1999, Smith and Doolittle, 1992)

Mn-SOD

(Feng et al., 2022, Gambini et al., 2021, Han et al., 2021, Yi et al., 2021, Yue et al., 2021, Bayliak et al., 2020, Panchal and Tiwari, 2020, Niveditha and Shivanandappa, 2018, Wang et al., 2017, Doganlar et al., 2015, Hosamani and Muralidhara, 2013, Besson et al., 2010, Orr et al., 2003)

Mn-SOD2

(Rival et al., 2009)

Mn²⁺SOD

(Wolkow, 2002)

MnSODII

(Yang et al., 2008)

MnSODa

(Hewitt and Degnan, 2022)

MnSod

(Chattopadhyay and Thirumurugan, 2020)

SOD

(Demir et al., 2022, Himalian et al., 2022, Huang et al., 2022, Strilbytska et al., 2022, Portela et al., 2021, Sheng et al., 2021, Paithankar et al., 2020, Demir and Marcos, 2018, Macedo et al., 2017, Rajak et al., 2017, Sonani et al., 2017, Subramanian et al., 2017, Wang et al., 2017, Medina-Leendertz et al., 2014, Iliadi et al., 2012, Grover et al., 2009, Magwere et al., 2006, Johnson, 1997)

SOD-2

(Melkani et al., 2013, Choudhary et al., 1992)

SOD-m

(Baroli et al., 2019)

SOD2

(Bai et al., 2023, Maurya and Tapadia, 2023, Yu et al., 2023, Yu et al., 2023, D'Souza et al., 2022, Wang et al., 2022, Cai et al., 2021, Zhang et al., 2021, De Lazzari et al., 2020, Hill et al., 2020, Matsumura et al., 2020, Muliyil et al., 2020, Sheard et al., 2020, Vaccaro et al., 2020, Bahhir et al., 2019, Baroli et al., 2019, Chaplot et al., 2019, Gupta et al., 2019, Perkins et al., 2019, Anderson-Baron and Simmonds, 2018, Niraula et al., 2018, Jiang et al., 2017, Kohyama-Koganeya et al., 2017, Liao et al., 2017, Pérez et al., 2017, Baron et al., 2016, Chen et al., 2016, Perkins et al., 2016, Qi et al., 2016, Wang et al., 2016, Wang et al., 2016, Bhandari et al., 2015, Chen et al., 2015, Kim et al., 2015, Liu et al., 2015, López Del Amo et al., 2015, O'Keefe et al., 2015, Reitman et al., 2015, Wang et al., 2015, Zhai et al., 2015, Zou et al., 2015, Bhandari et al., 2014, Faisal et al., 2014, Lim et al., 2014, Muliyil and Narasimha, 2014, Zhang et al., 2014, Huangfu et al., 2013, Krivy et al., 2013, Sen et al., 2013, Shen et al., 2013, Vincow et al., 2013, Zuo et al., 2013, Celotto et al., 2012, Dong et al., 2012, Iliadi et al., 2012, Koh et al., 2012, Liu et al., 2012, Peng et al., 2012, Sun et al., 2012, Zuo et al., 2012, Mukherjee et al., 2011, Peng et al., 2011, Sinenko et al., 2011, Sinenko et al., 2011, Sanz et al., 2010, Sinenko et al., 2010, Underwood et al., 2010, Martin et al., 2009, Bahadorani and Hilliker, 2008, Bahadorani and Hilliker, 2008, Kirby et al., 2008, Lee et al., 2008, Martin et al., 2007, Paul et al., 2007, Anderson et al., 2005, Helfand and Rogina, 2003)

Sod

(Naz et al., 2020, Rahul et al., 2020, Liao et al., 2017)

Sod-2

(Granat et al., 2023, Staatz et al., 2005)

Sod2

(Li et al., 2024, Alaraby et al., 2023, Hoffman et al., 2023, Muita and Baxter, 2023, Titus et al., 2023, Tuo et al., 2023, Yamada et al., 2023, Yang et al., 2023, Alaraby et al., 2022, Eickelberg et al., 2022, Fasae and Abolaji, 2022, Gera et al., 2022, Goyal et al., 2022, Guo et al., 2022, Martelli et al., 2022, Miozzo et al., 2022, Murari et al., 2022, Sen and Cox, 2022, Yan et al., 2022, Alaraby et al., 2021, Chen et al., 2021, Fabian et al., 2021, He et al., 2021, Hung et al., 2021, Joy et al., 2021, Le and Inoue, 2021, Missirlis, 2021, Pant et al., 2021, Watson et al., 2021, Yang et al., 2021, Chen et al., 2020, Fujisawa et al., 2020, Hope et al., 2020, Jeon et al., 2020, Jiang et al., 2020, Olufs et al., 2020, Pridie et al., 2020, Scialò et al., 2020, Vásquez-Procopio et al., 2020, Wong et al., 2020, Alaraby et al., 2019, Anyagaligbo et al., 2019, Banerjee et al., 2019, Barik and Mishra, 2019, Bayliak et al., 2019, Evangelakou et al., 2019, Gururaja Rao et al., 2019, Hall et al., 2019, Krittika and Yadav, 2019, Meltzer et al., 2019, Peng et al., 2019, Sanchez et al., 2019, Sênos Demarco and Jones, 2019, Tegeder et al., 2019, Toshniwal et al., 2019, Anderson-Baron and Simmonds, 2018, Biosa et al., 2018, Hill et al., 2018, Lee et al., 2018, Leow et al., 2018, Levis, 2018.8.30, Li et al., 2018, Liu et al., 2018, Muñoz-Soriano et al., 2018, Oberacker et al., 2018, Sakakibara et al., 2018, Staats et al., 2018, Staats et al., 2018, Stapper and Jahn, 2018, Thomas et al., 2018, Webber et al., 2018, Jo and Imm, 2017, Ng et al., 2017, Paiardi et al., 2017, Tan et al., 2017, Transgenic RNAi Project members, 2017-, Tsybul'ko et al., 2017, Filograna et al., 2016, Kubrak et al., 2016, Kučerová et al., 2016, Sanz, 2016, Sen and Cox, 2016, Calap-Quintana et al., 2015, Choo et al., 2015, Foriel et al., 2015, Kopp et al., 2015, Lashmanova et al., 2015, Oka et al., 2015, Rovenko et al., 2015, Rovenko et al., 2015, Sun and Chen, 2015, Belozerov et al., 2014, Blackney et al., 2014, Frost et al., 2014, Gao et al., 2014, Itsara et al., 2014, Luck et al., 2014, Mukherjee et al., 2014, Mukherjee et al., 2014, Na et al., 2014, Ruiz et al., 2014, Demontis et al., 2013, Faust et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Mandilaras and Missirlis, 2012, Vincent et al., 2012, Boyd et al., 2011, Jones and Grotewiel, 2011, Sinenko et al., 2011, Söderberg et al., 2011, Heifetz and Rivlin, 2010, Kim et al., 2010, Sinenko et al., 2010, Tsuda et al., 2010, Underwood et al., 2010, Wasbrough et al., 2010, Godenschwege et al., 2009, James et al., 2009, List et al., 2009, Martin et al., 2009, Owusu-Ansah and Banerjee, 2009, Piazza et al., 2009, Wicks et al., 2009, Zheng and Sehgal, 2009.6.23, Zheng and Sehgal, 2009.6.26, Anderson et al., 2008, Forde et al., 2008, Xun et al., 2008, Belton et al., 2007, Bhandari et al., 2007, Curtis et al., 2007, Dias-Santagata et al., 2007, Magwere et al., 2006, Landis and Tower, 2005, Duttaroy et al., 2003)

dSOD2

(Baek et al., 2022, Murari et al., 2022, Yoon et al., 2019, Carvalho et al., 2009)

dSod2

(Wang et al., 2011)

mitSOD2

(Rival et al., 2009)

mnSOD

(Vrailas-Mortimer et al., 2011, Tong et al., 2007, Phillips, 1994)

sod2

(Dong et al., 2022, Fernandez-Acosta et al., 2022, Gu et al., 2022, Wang et al., 2022, Asbah et al., 2021, Nandi and Chowdhuri, 2021, Wang et al., 2021, Ma et al., 2020, Lim et al., 2019, Petrova et al., 2018, Figueira et al., 2017, Fogle et al., 2015, Owusu-Ansah et al., 2013, Hirano et al., 2012, Sun et al., 2012, Wang et al., 2012, Milton et al., 2011)

Name Synonyms

Manganese Superoxide Dismutase

(Piazza et al., 2009)

Mn superoxide dismutase

(Mandilaras and Missirlis, 2012, Curtis et al., 2007)

Mn-superoxide dismutase

(Phillips, 1993.6.2)

MnSOD

(Li et al., 2008)

Superoxide Dismutase 2

(Krivy et al., 2013)

Superoxide dismutase

(Kang et al., 2002)

Superoxide dismutase 2

(Frost et al., 2014, Heifetz and Rivlin, 2010, Kim et al., 2010, Lai et al., 2007)

Superoxide dismutase 2 (Mn)

(Cammarato et al., 2011)

Superoxide dismutatase 2

(Gao et al., 2014)

Superoxidedismutase2 (Mn)

(Anderson-Baron and Simmonds, 2018)

manganese superoxide dismutase

(Zhao et al., 2012, Martin et al., 2009, Martin et al., 2007, Magwere et al., 2006)

manganese-SOD

(Curtis et al., 2007)

mitochodnrial SOD

(Mandavilli et al., 2002)

mitochondrial Mn-superoxide dismutase 2

(Rival et al., 2009)

mitochondrial MnSOD

(Bahadorani and Hilliker, 2008)

mitochondrial superoxide dismutase 2

(Iliadi et al., 2012, Boyd et al., 2011)

superoxide dismutase

(Grover et al., 2009)

superoxide dismutase 2

(Kubrak et al., 2016, Reitman et al., 2015, Zou et al., 2015, Faisal et al., 2014, Vincow et al., 2013, Sanz et al., 2010, Bhandari et al., 2007)

superoxide dismutase-2

(Sinenko et al., 2011)

superoxide dismutases 2

(Ramond et al., 2020)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 59 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36878

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q00637

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q00637

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4LGQ1

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q00637

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010213

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36878/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010213

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010213

FlyMine - An integrated database for Drosophila genomics

FBgn0010213

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8905

MARRVEL_MODEL - MARRVEL (model organism gene)

36878

Linkouts

BioGRID - A database of protein and genetic interactions.

62587

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010213

DroID - A comprehensive database of gene and protein interactions.

FBgn0010213

DRSC - Results frm RNAi screens

FBgn0010213

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sod2_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010213

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010213

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8905

Flygut - An atlas of the Drosophila adult midgut

FBgn0010213

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010213

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC005780

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

36878

MIST (protein-protein) - An integrated Molecular Interaction Database

36878

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Detoxification of Reactive Oxygen Species

References (399)