FlyBase Allele Report: Dmel\park[HMS01800]

Expressing park^HMS01800 under the control of Scer\GAL4^Mef2.PR disrupts the mitochondrial network, with increased mitochondrial aggregates and increased number of mitolysosomes, in both adult and larval muscles, and wing posture defects, and wing posture defects.

Expression under the control of Scer\GAL4^{αTub84B.Switch.PK} (induced by RU486 treatment) results in wing posture defects, decreased adult climbing activity and disorganization of muscle intestine fibers.

Expression under the control of Scer\GAL4^elav.PLu leads to a decrease in the number of PPL1 neurons and a decrease in mitolysosomes in the larval and adult brain; there is decreased climbing activity.

(Gumeni et al., 2021)

The eyes of adults expressing park^HMS01800 under the control of Scer\GAL4^GMR.PF show a progressive loss of rhabdomeres (more frequent at day 30 than at day 2).

(Liu et al., 2020)

Expression of park^HMS01800 under the control of Scer\GAL4^how-24B results in deficit in larval locomotion: the crawling speed, distance from start to finish as well as the total length travelled over time are all significantly reduced in the knock-down third instar larvae compared to controls.

(Brooks et al., 2016)

Expression of park^HMS01800 under the control of Scer\GAL4^tin.CΔ4 evokes heart tube hypocontractility one and four weeks after eclosion, and increases cardiomyocyte mitochondrial size. Lifespan is similar to controls. The flies display an accelerated age-related decline in climbing performance.

(Bhandari et al., 2014)

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Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^ple.PU, park^HMS01800 has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible by Scer\GAL4^ple.PU/TP53INP^FENLL.UAS

(Dinh et al., 2021)

Scer\GAL4^{αTub84B.Switch.PK}, park^HMS01800 has visible | adult stage | RU486 conditional phenotype, suppressible by Scer\GAL4^{αTub84B.Switch.PK}/cnc^UAS.cSa

(Gumeni et al., 2021)

Scer\GAL4^elav.PLu, park^HMS01800 has abnormal locomotor behavior | adult stage phenotype, suppressible by cnc^UAS.cSa/Scer\GAL4^elav.PLu

(Gumeni et al., 2021)

NOT suppressed by

Statement

Reference

Scer\GAL4^elav.PLu, park^HMS01800 has abnormal neuroanatomy | adult stage phenotype, non-suppressible by cnc^UAS.cSa/Scer\GAL4^elav.PLu

(Gumeni et al., 2021)

Scer\GAL4^elav.PLu, park^HMS01800 has decreased cell number | adult stage phenotype, non-suppressible by cnc^UAS.cSa/Scer\GAL4^elav.PLu

(Gumeni et al., 2021)

Suppressor of

Statement

Reference

park^HMS01800, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage | progressive phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

NOT Suppressor of

Statement

Reference

park^HMS01800/Scer\GAL4^Cg.PA is a non-suppressor of decreased cell size | third instar larval stage phenotype of Scer\GAL4^Cg.PA, Tom40^JF02030

(Liu et al., 2018)

Pink1^UAS.cCa/park^HMS01800, Scer\GAL4^Cg.PA is a non-suppressor of decreased cell size | third instar larval stage phenotype of Scer\GAL4^Cg.PA, Tom40^JF02030

(Liu et al., 2018)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^Mef2.PR, park^HMS01800 has mitochondrion | adult stage phenotype, enhanceable by ref(2)P^HMS00551/Scer\GAL4^{αTub84B.Switch.PK}

(Gumeni et al., 2021)

Scer\GAL4^Mef2.PR, park^HMS01800 has adult somatic muscle cell phenotype, enhanceable by ref(2)P^HMS00551/Scer\GAL4^{αTub84B.Switch.PK}

(Gumeni et al., 2021)

Scer\GAL4^GMR.PF, park^HMS01800 has rhabdomere | adult stage phenotype, enhanceable by Chchd2^8-8

(Liu et al., 2020)

Suppressed by

Statement

Reference

Scer\GAL4^Mef2.PR, park^HMS01800 has adult somatic muscle cell phenotype, suppressible by Scer\GAL4^Mef2.PR/cnc^UAS.cSa

(Gumeni et al., 2021)

Scer\GAL4^Mef2.PR, park^HMS01800 has mitochondrion | adult stage phenotype, suppressible by Scer\GAL4^Mef2.PR/cnc^UAS.cSa

(Gumeni et al., 2021)

Scer\GAL4^{αTub84B.Switch.PK}, park^HMS01800 has wing | RU486 conditional phenotype, suppressible by Scer\GAL4^{αTub84B.Switch.PK}/cnc^UAS.cSa

(Gumeni et al., 2021)

Scer\GAL4^Mef2.PR, park^HMS01800 has mitochondrion | adult stage phenotype, suppressible by ref(2)P^HMS00551/Scer\GAL4^{αTub84B.Switch.PK}/cnc^UAS.cSa

(Gumeni et al., 2021)

Scer\GAL4^Mef2.PR, park^HMS01800 has adult somatic muscle cell phenotype, suppressible by ref(2)P^HMS00551/Scer\GAL4^{αTub84B.Switch.PK}/cnc^UAS.cSa

(Gumeni et al., 2021)

Scer\GAL4^tin.CΔ4, park^HMS01800 has adult heart phenotype, suppressible by Sod2^UAS.cMa/Scer\GAL4^tin.CΔ4

(Bhandari et al., 2014)

Scer\GAL4^tin.CΔ4, park^HMS01800 has adult heart phenotype, suppressible by Marf^RNAi.cUa.UAS, Scer\GAL4^tin.CΔ4

(Bhandari et al., 2014)

Scer\GAL4^tin.CΔ4, park^HMS01800 has cardial cell phenotype, suppressible by Sod1^UAS.cWa/Scer\GAL4^tin.CΔ4

(Bhandari et al., 2014)

Scer\GAL4^tin.CΔ4, park^HMS01800 has cardial cell phenotype, suppressible by Sod2^UAS.cMa/Scer\GAL4^tin.CΔ4

(Bhandari et al., 2014)

Scer\GAL4^tin.CΔ4, park^HMS01800 has cardial cell phenotype, suppressible by Marf^RNAi.cUa.UAS, Scer\GAL4^tin.CΔ4

(Bhandari et al., 2014)

Scer\GAL4^tin.CΔ4, park^HMS01800 has mitochondrion phenotype, suppressible by Sod1^UAS.cWa/Scer\GAL4^tin.CΔ4

(Bhandari et al., 2014)

Scer\GAL4^tin.CΔ4, park^HMS01800 has mitochondrion phenotype, suppressible by Sod2^UAS.cMa/Scer\GAL4^tin.CΔ4

(Bhandari et al., 2014)

Scer\GAL4^tin.CΔ4, park^HMS01800 has mitochondrion phenotype, suppressible by Marf^RNAi.cUa.UAS, Scer\GAL4^tin.CΔ4

(Bhandari et al., 2014)

Scer\GAL4^tin.CΔ4, park^HMS01800 has adult heart phenotype, suppressible by Sod1^UAS.cWa/Scer\GAL4^tin.CΔ4

(Bhandari et al., 2014)

NOT suppressed by

Statement

Reference

Scer\GAL4^elav.PLu, park^HMS01800 has dopaminergic PPL1 neuron | decreased number phenotype, non-suppressible by cnc^UAS.cSa/Scer\GAL4^elav.PLu

(Gumeni et al., 2021)

Enhancer of

Statement

Reference

park^HMS01800/Scer\GAL4^GMR.PF is an enhancer of rhabdomere | adult stage phenotype of Chchd2^8-8

(Liu et al., 2020)

Suppressor of

Statement

Reference

park^HMS01800, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

NOT Suppressor of

Statement

Reference

park^HMS01800/Scer\GAL4^Mef2.PR is a non-suppressor of mitochondrion | adult stage phenotype of Pink1^B9

(Ham et al., 2021)

park^HMS01800/Scer\GAL4^Cg.PA is a non-suppressor of fat cell | early third instar larval stage phenotype of Scer\GAL4^Cg.PA, Tom40^JF02030

(Liu et al., 2018)

park^HMS01800/Scer\GAL4^Cg.PA is a non-suppressor of autophagosome | early third instar larval stage phenotype of Scer\GAL4^Cg.PA, Tom40^JF02030

(Liu et al., 2018)

Pink1^UAS.cCa/park^HMS01800, Scer\GAL4^Cg.PA is a non-suppressor of fat cell | early third instar larval stage phenotype of Scer\GAL4^Cg.PA, Tom40^JF02030

(Liu et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Sod^Scer\UAS.cWa suppresses the heart tube hypocontraction and increase in mitochondrial reactive oxygen species (ROS) seen when park^HMS01800 is expressed under the control of Scer\GAL4^tin.CΔ4.

Expression of Sod2^Scer\UAS.cMa suppresses the heart tube hypocontraction and increase in mitochondrial reactive oxygen species (ROS) seen when park^HMS01800 is expressed under the control of Scer\GAL4^tin.CΔ4.

Expression of CG6878^KK108566 suppresses the heart tube hypocontraction and increase in mitochondrial reactive oxygen species (ROS) seen when park^HMS01800 is expressed under the control of Scer\GAL4^tin.CΔ4.

Co-expression of Marf^{miRNA.cUa.Scer\UAS} and park^HMS01800 under the control of Scer\GAL4^tin.CΔ4 suppresses the heart tube cardiomyopathy and some of the mitochondrial defects seen when either transgene is expressed alone. The proportion of reactive oxygen species (ROS)-producing and depolarized organelles is reduced, and the reduction in mitochondrial DNA content seen in flies expressing park^HMS01800 is rescued. However, the mitochondria show characteristics of both parent lines: they are still enlarged as is seen with park^HMS01800, and appear fragmented as is seen with Marf^{miRNA.cUa.Scer\UAS}.

(Bhandari et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

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Mutant

Wild-type

Stocks (2)

Bloomington

38333