Isocitrate dehydrogenase, l(3)L3852, IDH-NADP, ICDH, IDH1
phenotype
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allele synonym ref α residual heterodimer
activity formation
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IdhF Idh6 3, 4
IdhnGB1 2, 6, 7 0 +
IdhnGB2 IdhGB2 1, 2, 6, 7 5% β -
IdhnNC1 2, 6, 7 0 +
IdhS Idh4 3, 4
IdhSS Idh2 5
α
1 = Bentley, Meidinger, and Williamson, 1983, Biochem.
Genet. 21: 725-33; 2 = Burkhart, Montgomery, Langley, and
Voelker, 1984, Genetics 107: 295-306; 3 = Fox, 1970, DIS
45: 35; 4 = Fox, 1971, Biochem. Genet. 5: 69-80; 5 = Fox,
1972, DIS 48: 20; 6 = Langley, Voelker, Leigh Brown,
Ohnishi, Dickson, and Montgomery, 1981, Genetics 99: 151-
56; 7 = Voelker, Langley, Leigh Brown, Ohnishi, Dickson, and
Montgomery, and Smith, 1980 Proc. Nat. Acad. USA 77: 1091-
95.
β
24% wild-type levels of CRM; kinetic properties of residual
activity indistinguishable from those of wild type.
Please see the JBrowse view of Dmel\Idh for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
933 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Idh using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Idh in JBrowse
3-24
3-19.5
3-27.1
3-27.2
3-25.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
CG7176 encodes a putative cytoplasmic form of IDH.
The relationship between survival, sex and Idh phenotypes is submitted to the paraquat bioassay and results show an intersection between the way in which oxidative damage affects bioenergetic pathways and its influence on the development and aging processes.
Idh enzyme activity has been measured in D.melanogaster lines in which spontaneous mutations have accumulated over approximately 300 mutations.
Gramoxone has no mutagenic effect on the genetic background of Idh.
Structural gene or genes for NADP+-dependent isocitrate dehydrogenase <up>threo-D- isocitrate:NADP+ oxydoreductase (decarboxylating)</up> (IDH).
Studies of purified enzyme indicate it to have a molecular weight of 110,000 and to be a dimer of subunits with molecular weights 60,000 and 50,000.
Source for merge of: Idh l(3)L3852
Source for merge of: l(3)L3852 CG7176
Source for merge of Idh l(3)L3852 was map position and function ( date:020805 ).
Source for merge of l(3)L3852 CG7176 was a shared cDNA (GH01524) ( date:011030 ).
