l(1)G0056, l(1)G0127, IMPDH, l(1)G0436, l(1)G0391
Please see the JBrowse view of Dmel\ras for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.51
Gene model reviewed during 5.45
Gene model reviewed during 5.56
Stop-codon suppression (UAA) postulated; FBrf0234051.
Gene model reviewed during 6.25
2.5, 1.9 (northern blot)
2.4 (northern blot)
537 (aa); 58 (kD predicted)
537 (aa)
Bacterially expressed ras protein has inosine monophosphate dehydrogenase activity.
Homotetramer.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ras using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: reported as muscle system primordium
Comment: reported as muscle system primordium
JBrowse - Visual display of RNA-Seq signals
View Dmel\ras in JBrowse1-32
1-33.7
1-32.35
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
Inosine monophosphate dehydrogenase (IMPD) is the product of the ras locus.
Mutant analysis suggests that GMP synthesis from IMP is an essential process, and that activity of the ras gene product, IMPDH, is regulated in a tissue-specific manner.
ras is but one of four types of mutations belonging to an interrelated complex involved some way in purine metabolism: ras, a nonauxotrophic eye-color mutant; two purine auxotrophs, pur1 and gua1, which complement ras and one another; and ras lethal alleles that fail to complement completely the other three types. The complex shares genetic features with r.
Defective in pteridine synthesis; eye color dark ruby. Appears to affect the level of guanosine triphosphate cyclohydrolase activity; ras alleles exhibit increased activity compared to wild type at pupariation, but decreased activity at eclosion (FBrf0031059). Not a purine auxotroph. Color autonomous in larval optic discs transplanted into wild-type hosts (FBrf0003530). ras1/ras-lethal display ras eye color. Larval Malpighian tubes nearly wildtype; not useful for classification FBrf0005752).
Source for merge of: ras CG11485 CG1799
Source for merge of: ras l(1)G0388 l(1)G0391 l(1)G0002 l(1)G0056 l(1)G0351 l(1)G0482 l(1)G0098 l(1)G0127 l(1)G0436 l(1)G0238