Oaz, l(2)03563, O/E-associated zinc finger protein, Dm_2R:42259
zinc finger transcription factor required for eye cell survival - regulates eye development through the TOR pathway
Please see the JBrowse view of Dmel\L for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.43
Gene model reviewed during 5.50
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\L using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as larval eye primordium
Comment: reported as posterior spiracle specific anlage
L expression is observed in stage 14 embryos in the dorso-posterior part of the brain and in the anterior and posterior spiracles. Later, it is expressed in a segmentally-repeated pattern. Staining persists in the larval stages in the spiracles and brain. It is observed in leg disc but in other discs.
JBrowse - Visual display of RNA-Seq signals
View Dmel\L in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Oaz mutant larvae show defects in the filzkorper of the posterior spiracles.
L is required non-autonomously for ventral growth but not dorsal growth in the eye disc.
A number of unstable mutations in the L locus have been induced by microinjection of Rous sarcoma virus cDNA.
Variable reduction in eye size of heterozygotes and homozygotes as well as in homozygous viability, depending on allele. Most extreme allele, L2, exhibits reduced eyes in heterozygote and tiny eyes and poor viability in homozygote; classifiable in single dose in triploids (Schultz, 1934). L1/+ have slightly reduced eyes with nick in anterior edge and the lower half of eye reduced more than upper; overlaps wild type; eyes of homozygote much smaller and less variable; bipartite eyes occasionally formed. Lr shows weakest expression, with the heterozygote indistinguishable from wild type and the homozygote with small kidney-shaped eyes at 25oC, but overlapping wild type at 19oC. Tested alleles (L4, LB, Ld, Lr) exhibit reduced expression at 19oC compared to 25oC. Expression enhanced (L1, L2, L4) in combination with Minutes <up>M(2)58F, M(3)69E, RpS3</up> (Dunn and Coyne, 1935). Reduced numbers of cells enter into formation of eye discs (L2, L4, L5, Steinberg, 1944); reduced size of cephalic complex detectable in 24-hr larva, but subsequent growth rate is similar to wild type (L4, Medvedev, 1935; Medvedev, 1935).
Source for merge of: L Oaz
Source for merge of: Oaz CG17388 CG17389
Source for merge of: Oaz l(2)03563
FBrf0151277 reports that the L (Lobe) mutant complementation group corresponds to the CG10109 annotation (based on the ability of a CG10109 construct to rescue L mutant phenotypes and mapping of the lesion in a L mutant). However, FBrf0217295 reports that L does not correspond to the CG10109 annotation (based on the failure to of a CG10109 construct to rescue L mutant phenotypes and the viability of a L mutant allele over a deficiency that removes CG10109). The L (Lobe) mutant complementation group has been split out from the CG10109 annotation in FlyBase until this is resolved. Thus, in release 6.03 of the genome annotation, annotation CG46146 replaces CG10109 and is split from the Lobe (L) gene.
The L[rev6-3] lethal allele is viable over a deficiency (Df(2R)ED2354) that removes the CG10109 gene and the lethality is not rescued by expression of a UAS-CG10109 line (P{UAS-PRAS40.C}), suggesting that the L complementation group does not correspond to CG10109.
Annotations CG17390, CG17388, and CG17389 merged as CG42702 in release 5.26 of the genome annotation.
"ne1" is probably an allele of "L".
Source for identity of: Oaz CG17390
