BarH1, B
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Bar using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Bar in JBrowse1-57.0
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The progression of the morphogenetic furrow in the developing eye disc arrests in a B mutant. The eye disc appears normal at the time of arrest. dpp expression is abolished (as assayed with a dpp-lacZ fusion gene).
Phenotypic variation of the genetic components underlying oviposition behaviour is analysed using the complete diallel mating design.
Position effect variegation dominantly suppressed by an allele of mod.
From successive unequal crossovers in attached X's, Rapoport (FBrf0005199; FBrf0005292) was able to accumulate as many as 7 or 9 B regions in a single chromosome. B is the first recorded instance of position effect. Presumably results from the new band association 16A7-16A1 and can be reversed by rearrangements that separate these bands. Also the first case of cis-trans position effect, two 16A7-16A1 associations in the same chromosome producing greater facet reduction than one association in each of two homologous chromosomes.
Homozygous female fully viable. B1/+ female has about 360 facets and shows indentation terminating in horizontal fissure on anterior margin of eye, producing a kidney-shaped eye. B1/B1 and B1/+ completely separable from wild type; in some genetic backgrounds, B1/B1 overlaps B1/+ slightly. Variegated position effect derivatives of Dp(1;Y)BS (Dp(1;Y)BSCV) exhibit nonmutant phenotypes in XY males but narrow eyes in XYY males. Disc size reduced; morphogenetic furrow absent.
This study raises the possibilty that B-H1, not B, is the Bar gene and that more than one gene may be involved in Bar position effects.
The Om(1D) gene of D.ananassae may be homologous to the Bar gene of D.melanogaster.
Adult eye is small, narrow with about 150 facets. Ommatidia are usually normal. Eye disc size is reduced, due to precursor cell defects.
Introduction of B1 into a strain of flies characterized by jumping in response to a sudden decrease in light intensity nearly eliminates response; response rescued by increasing facet number through lactamide feeding during larval development.
Cell death observed in anterior presumptive ommatidium-forming region of eye disc. High acid phosphatase levels characteristic of liposomal activity seen at same time as cell death in eye disc. Reduction in facet number, increase in acid phosphatase activity and cell death in mutants are inhibited in larvae grown on medium supplemented with acetamide or lactamide.
Cell death observed in anterior presumptive ommatidium-forming region of eye disc. Reduction in facet number, increase in acid phosphatase activity and cell death in mutants are inhibited in larvae grown on medium supplemented with acetamide or lactamide.
Cell death observed in anterior presumptive ommatidium-forming region of eye disc.
Double amides are more effective than single at inhibiting reduction in facet number, increase in acid phosphatase activity and cell death in B mutants.
Enhancers of variegation Df(2R)M41A10 and E(var)7 shift the B mutant phenotype toward normal.
Facet development of mutants enhanced in organ culture by addition of wild type cephalic complexes.
Reduction in facet number, increase in acid phosphatase activity and cell death in mutants are inhibited in larvae grown on medium supplemented with acetamide or lactamide.
Eyes of female heterozygous for a deficiency for B and a normal X are normal.
Pigmented but nonfaceted part of eye shows retinulae and dioptic apparatus lacking, but rudimentary ommatidia present, consisting of hypertrophied accessory cells.
Classifiable in single dose in triploids by slight anterior nick in eye; is useful in the recognition of triploids.
Nonautonomous over short distances.
Log of facet number inversely proportional to temperature of development.
Eye restricted to narrow vertical bar of about 90 facets in the male and 70 facets in the female, as contrasted with normal numbers of about 740 for males and 780 for females.
Dp(1;3)DC329 (which encompasses B-H1) causes a Bar eye phenotype in males and females.
Dp(1;3)DC328 (which encompasses B-H2 but not B-H1) does not exhibit a Bar phenotype.
Derivatives of B with altered phenotypes, including reversions to normal phenotype, have been given allelic designations. These derivatives are summarized under the individual alleles. Unless otherwise indicated, fuller descriptions are found in Lindsley and Grell, 1968. Where tested the lethal alleles are cell lethal in cuticular spots. Different alleles of B that are not involved in gross chromosome aberrations can be combined in all pair-wise combinations by means of unequal crossing over in heterozygous females. Described combinations are B Bi, Bi B and Bi Bi (Sturtevant, 1925); Bi40b Bi40b (Steinberg, 1942); B B3, B B36b and B Bl (Muller).
Source for identity of: Bar B
Changed gene symbol 'B' to 'Bar' to eliminate the case-insensitive duplication with the 'b' (black) gene symbol.
