FB2024_04 , released June 25, 2024
Gene: Dmel\E(spl)mα-BFM
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General Information
Symbol
Dmel\E(spl)mα-BFM
Species
D. melanogaster
Name
Enhancer of split mα, Bearded family member
Annotation Symbol
CG8337
Feature Type
protein_coding_gene
FlyBase ID
FBgn0002732
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Enhancer of split mα, Bearded family member (E(spl)mα-BFM) encodes one of the basic helix-loop-helix (bHLH) transcription factors that are responsive to Notch signaling. It is involved in cellular processes downstream of Notch signaling such as cell fate specification and sensory organ development. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)
All Summaries
Also Known As

mα, E(spl)mα, malpha, E(spl)malpha, E(spl) region transcript mα

Key Links
Genomic Location
Cytogenetic map
96F10-96F10
Sequence location
Recombination map
3-89
RefSeq locus
NT_033777 REGION:26010893..26011568
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables ubiquitin protein ligase binding
inferred from physical interaction with FLYBASE:neur; FB:FBgn0002932
(Fontana and Posakony, 2009, Bardin and Schweisguth, 2006)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in cell fate specification
inferred from mutant phenotype
(Lai et al., 2000)
involved_in negative regulation of Notch signaling pathway
inferred from mutant phenotype
(Fontana and Posakony, 2009, Apidianakis et al., 1999)
involved_in sensory organ development
inferred from mutant phenotype
(Apidianakis et al., 1999)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in Notch signaling pathway
inferred from electronic annotation with InterPro:IPR029686
(InterPro Project Members, 2004-)
involved_in sensory organ development
inferred from electronic annotation with InterPro:IPR029686
(InterPro Project Members, 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the M4-like protein family. (O97178)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Enhancer of split mα, Bearded family member (E(spl)mα-BFM) encodes one of the basic helix-loop-helix (bHLH) transcription factors that are responsive to Notch signaling. It is involved in cellular processes downstream of Notch signaling such as cell fate specification and sensory organ development. [Date last reviewed: 2019-09-26]
Gene Group (FlyBase)
ENHANCER OF SPLIT GENE COMPLEX -
The Enhancer of split complex (E(spl)-C) of D.mel is a well characterized genetic locus on chromosome 3R containing 12 genes - with the exception of Kaz-m1, all are Notch responsive. Seven genes are basic helix-loop-helix (bHLH) transcription factors, four are bearded family genes. Kaz-m1 is unrelated, sharing some sequence similarity to Kazal class protease inhibitors. (Adapted from FBrf0211195).
BEARDED GENE FAMILY -
The Bearded gene family, named from homology with Brd, encode small proteins containing predicted basic amphipathic α-helical domains in their N-terminal regions. They are located in two genomic complexes - the Bearded Complex and the Enhancer of Split Complex. Some members have been implicated in Notch signaling. (Adapted from FBrf0123097).
Pathway (FlyBase)
Negative Regulators of Notch Signaling Pathway -
The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Negative regulators of the pathway down-regulate the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).
Protein Function (UniProtKB)
Part of the Notch signaling pathway.
(UniProt, O97178)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\E(spl)mα-BFM for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O97178)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.42

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
E(spl)mα-BFM-RA
FBtr0084956
NM_079782
676
138
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
E(spl)mα-BFM-PA
FBpp0084330
15.9
138
4.43
O97178
NP_524506
AAF56547
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

138 (aa)

(Lai et al., 2000, Wurmbach et al., 1999)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\E(spl)mα-BFM using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.45

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 6 -- 7
mesectoderm
(Wurmbach et al., 1999)
embryonic stage 8 -- 17
mesoderm
(Wurmbach et al., 1999)
ventral neurectoderm
(Wurmbach et al., 1999)
embryonic stage 9
hindgut proper primordium | posterior
(Chanet and Schweisguth, 2012)
third instar larval stage
proneural cluster
(Wurmbach et al., 1999)
wing cell
(Wurmbach et al., 1999)
wing disc | restricted
(Lai et al., 2000, Wurmbach et al., 1999)
wing vein
(Lai et al., 2000)
wing margin
(Wurmbach et al., 1999)
leg disc
(Wurmbach et al., 1999)
eye disc morphogenetic furrow
(Lai et al., 2000, Wurmbach et al., 1999)
proneural cluster of wing disc
(Lai et al., 2000, Wurmbach et al., 1999)
eye disc
(Lai et al., 2000, Wurmbach et al., 1999)
proneural cluster of leg disc
(Wurmbach et al., 1999)
eye disc posterior to the morphogenetic furrow
(Lai et al., 2000, Wurmbach et al., 1999)
prepupal stage P2
segment of leg | segment boundary
(Lai et al., 2000)
prepupal stage P4
campaniform sensillum of wing

Comment: 8 hr APF

(Lai et al., 2000)
prepupal stage P4 -- pupal stage P6
wing | restricted

Comment: 8-30 hr APF

(Lai et al., 2000)
pupal stage P6
wing vein

Comment: 30 hr APF

(Lai et al., 2000)
wing blade

Comment: 30 hr APF

(Lai et al., 2000)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
organism
(Maeder et al., 2009)
prepupal stage
organism
(Maeder et al., 2009)
Additional Descriptive Data

E(spl) genes were found to be differentially expressed during metamorphosis. E(spl)mα-BFM levels are low during wandering third instar stage, show a 1.5 fold increase from early to late third instar, a 3.3 fold increase at pupariation formation, and a 2.3 fold increase 2-3 hours post-puparium formation. E(spl)mα-BFM is one of 4 genes to increase in expression at puparium formation and one of 5 genes that shows an increase at 2-3 hours post-puparium formation.

(Maeder et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\E(spl)mα-BFM in JBrowse
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of E(spl)mα-BFM
Transgenic constructs containing regulatory region of E(spl)mα-BFM
Aberrations (Deficiencies and Duplications) ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | pupal stage, with Scer\GAL4pnr-MD237
partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
Other Phenotypes
Allele
abnormal body color, with Scer\GAL4pnr-MD237
visible, with Scer\GAL469B
visible, with Scer\GAL4455.2
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4ptc-559.1
visible, with Scer\GAL4sca-537.4
visible, with Scer\GAL4sca-T3
Phenotype manifest in
Allele
adult sense organ, with Scer\GAL4sca-537.4
campaniform sensillum, with Scer\GAL4455.2
campaniform sensillum, with Scer\GAL4ap-md544
campaniform sensillum, with Scer\GAL4pnr-MD237
campaniform sensillum, with Scer\GAL4ptc-559.1
campaniform sensillum, with Scer\GAL4sca-T3
dorsal row & sensory mother cell, with Scer\GAL4ap-md544
dorsocentral bristle, with Scer\GAL4pnr-MD237
eo neuron, with Scer\GAL4pnr-MD237
macrochaeta, with Scer\GAL4455.2
macrochaeta, with Scer\GAL4ap-md544
macrochaeta, with Scer\GAL4pnr-MD237
macrochaeta, with Scer\GAL4ptc-559.1
macrochaeta, with Scer\GAL4sca-T3
macrochaeta & scutum, with Scer\GAL4pnr-MD237
macrochaeta | ectopic, with Scer\GAL4sca-537.4
mesothoracic tergum, with Scer\GAL4pnr-MD237
microchaeta, with Scer\GAL4455.2
microchaeta, with Scer\GAL4ap-md544
microchaeta, with Scer\GAL4pnr-MD237
microchaeta, with Scer\GAL4ptc-559.1
microchaeta, with Scer\GAL4sca-T3
microchaeta & scutum, with Scer\GAL4pnr-MD237
scutellar bristle, with Scer\GAL4455.2
sensory mother cell | ectopic, with Scer\GAL4bi-omb-Gal4
thecogen cell, with Scer\GAL4pnr-MD237
tormogen cell, with Scer\GAL4pnr-MD237
trichogen cell, with Scer\GAL4pnr-MD237
wing margin bristle, with Scer\GAL469B
wing margin bristle, with Scer\GAL4Bx-MS1096
wing sensillum & wing vein, with Scer\GAL469B
wing sensillum & wing vein, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (0)
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (0)
Mus musculus (laboratory mouse) (0)
Xenopus tropicalis (Western clawed frog) (0)
Danio rerio (Zebrafish) (0)
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP012341
3 of 12
Yes
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:E(spl)mα-BFM. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (3)
Ocho
4 of 13
Tom
4 of 13
E(spl)m4-BFM
3 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    RNA-RNA
    Physical Interaction
    Assay
    References
    E(spl)mα-BFM - mir-11
    fluorescence technology
    (Lai et al., 2005)
    E(spl)mα-BFM - mir-2a-1
    fluorescence technology
    (Lai et al., 2005)
    E(spl)mα-BFM - mir-2a-2
    fluorescence technology
    (Lai et al., 2005)
    E(spl)mα-BFM - mir-4
    fluorescence technology
    (Lai et al., 2005)
    E(spl)mα-BFM - mir-79
    fluorescence technology
    (Lai et al., 2005)
    protein-protein
    Physical Interaction
    Assay
    References
    E(spl)mα-BFM - neur
    pull down, western blot, two hybrid
    (Fontana and Posakony, 2009, Bardin and Schweisguth, 2006)
    Summary of Genetic Interactions
    esyN Network Diagram
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    esyN Network Key:
    Suppression
    Enhancement
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    E(spl)mα-BFM
    enhanceable
    N
    (Apidianakis et al., 1999)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    E(spl)m4-BFM
    enhanceable
    E(spl)mα-BFM
    (Apidianakis et al., 1999)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Negative Regulators of Notch Signaling Pathway -
    The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Negative regulators of the pathway down-regulate the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-89
    Cytogenetic map
    96F10-96F10
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    96F10-96F10
    Limits computationally determined from genome sequence between P{PZ}l(3)rQ197rQ197 and P{lacW}scribj7B3
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    96F11-96F14
    (Nellesen, 1998.12.18, Wurmbach, 1998.8.16)
    Experimentally Determined Recombination Data
    Location

    3-89

    (FlyBase, 2016)

    3-87.4

    (Comeron et al., 2012)

    3-89.1

    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (7)
    Genomic Clones (14)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (11)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            Overexpression of mα antagonises the N pathway in multiple cell fate decisions during adult sensory organ development.

            (Lai et al., 2000)

            m4 and mα are involved in N mediated lateral inhibition in sensory organ precursor singularization.

            (Apidianakis et al., 1999)

            The distinct expression patterns of genes of the E(spl) complex in imaginal tissues depend to a significant degree on the capacity of their transcriptional cis-regulatory apparatus to respond selectively to direct proneural and Su(H)-mediated activation, often in a subset of the territories and cells in which proneural and Su(H) regulation is occurring.

            (Nellesen et al., 1999)

            The bristle loss phenotype of H mutants can be suppressed by deleting components of the E(spl)-complex. The degree of suppression depends on both the number and identity of E(spl)-complex transcription units removed.

            (Bang et al., 1995)

            One of the Enhancer-of-split complex.

            Relationship to Other Genes
            Source for database merge of
            Additional comments
            Nomenclature History
            Source for database identify of

            Source for identity of: E(spl)mα-BFM mα

            (Artavanis-Tsakonas et al., 2012.8.8)
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (15)
            Reported As
            Symbol Synonym
            CG8337
            (Hosono et al., 2015, Keleman et al., 2009.8.5, Krejcí et al., 2009, Perkins et al., 2009, Bhutkar et al., 2008, Schlatter and Maier, 2005)
            DmelCG8337
            (Duncan and Dearden, 2010)
            E(spl) mα
            (Rice et al., 2020, Zhan et al., 2013)
            E(spl)ma
            (Castro et al., 2001)
            E(spl)malpha
            (Lu and Li, 2015, Li and White, 2003, Nellesen, 1998.12.18, Wurmbach, 1998.8.16)
            E(spl)malpha-BFM
            (Cho et al., 2020)
            E(spl)mmα
            (Johansson et al., 2005)
            E(spl)mα
            (Gagliani et al., 2022, Bonfini et al., 2021, Gomez-Lamarca et al., 2018, Wissel et al., 2018, Duan et al., 2011, Cohen et al., 2010, Fontana and Posakony, 2009, Krejcí et al., 2009, Kaspar et al., 2008, Castro et al., 2005, Lai et al., 2005, Barolo et al., 2004, Castro et al., 2002, Lai, 2002, Rebeiz et al., 2002, Lai et al., 2000, Zaffran and Frasch, 2000, Bodner et al., 1999, Lai et al., 1999)
            E(spl)mα-BFM
            (Josserand et al., 2023, Kuyateh and Obbard, 2023, Ferguson et al., 2021, Michki et al., 2021, Hung et al., 2020, Wurmbach and Preiss, 2014)
            HLHmalpha
            (Southall et al., 2013)
            HLHmα
            (Moshkin et al., 2013, Bhutkar et al., 2008)
            malpha
            (Lu and Li, 2015, Schaaf et al., 2013, Terriente-Felix et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Johnson et al., 2011, Blanco et al., 2010, Cunha et al., 2010, Krejcí et al., 2009, Magalhaes et al., 2007)
            mα
            (Guo et al., 2019, Miller and Posakony, 2018, Perez-Mockus et al., 2017, Horvath et al., 2016, Jin et al., 2013, Moshkin et al., 2013, Schaaf et al., 2013, Liu and Posakony, 2012, Cave et al., 2011, Zhou et al., 2011, Bardin et al., 2010, Duncan and Dearden, 2010, Chanet et al., 2009, Maeder et al., 2009, Schaaf et al., 2009, Goodfellow et al., 2007, Krejci and Bray, 2007, Maeder et al., 2007, Bardin and Schweisguth, 2006, Chan et al., 2005, Liu et al., 2005, Macdonald and Long, 2005, Schlatter and Maier, 2005)
            Name Synonyms
            E(spl) region transcript mα
            (Krejcí et al., 2009, Zhou et al., 2008)
            E(spl)mα
            (Barad et al., 2010)
            Enhancer of split mα, Bearded family member
            Secondary FlyBase IDs
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 237 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Flygut - An atlas of the Drosophila adult midgut
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              References (111)