FlyBase Allele Report: Dmel\Synd[661T]

General Information

Symbol

Dmel\Synd^661T

Species

D. melanogaster

Name

FlyBase ID

FBal0356490

Feature type

allele

Associated gene

Dmel\Synd

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

antimorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Ogi et al., 2019)

Mutagen

ethyl methanesulfonate

(Ogi et al., 2019)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q329term.

(Ogi et al., 2019)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:20,838,597..20,838,597 [+]

Nucleotide change:

C20838597T

Amino acid change:

Q329term | Synd-PB; Q329term | Synd-PC; Q329term | Synd-PD

Reported amino acid change:

Q329term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change. A point mutation causing a E509K change in GluRIID, which was not associated with the rhabdomere phenotype, was also identified in this strain.

(Ogi et al., 2019)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage

(Ogi et al., 2019)

abnormal neuroanatomy | adult stage | recessive | somatic clone

(Ogi et al., 2019)

abnormal neuroanatomy | pupal stage (with Df(3R)BSC43)

(Ogi et al., 2019)

abnormal neuroanatomy | pupal stage (with Synd^mut1)

(Ogi et al., 2019)

abnormal neuroanatomy | pupal stage | recessive | somatic clone

(Ogi et al., 2019)

viable (with Df(3R)BSC43)

(Ogi et al., 2019)

viable (with Df(3R)BSC124)

(Ogi et al., 2019)

viable (with Df(3R)BSC141)

(Ogi et al., 2019)

viable (with Df(3R)BSC475)

(Ogi et al., 2019)

viable (with Df(3R)BSC488)

(Ogi et al., 2019)

viable (with Df(3R)BSC516)

(Ogi et al., 2019)

viable (with Df(3R)BSC517)

(Ogi et al., 2019)

viable (with Df(3R)BSC518)

(Ogi et al., 2019)

viable (with Df(3R)BSC680)

(Ogi et al., 2019)

viable (with Df(3R)BSC808)

(Ogi et al., 2019)

viable (with Df(3R)BSC809)

(Ogi et al., 2019)

viable (with Df(3R)BSC818)

(Ogi et al., 2019)

viable (with Df(3R)BSC819)

(Ogi et al., 2019)

viable (with Df(3R)ED5942)

(Ogi et al., 2019)

viable (with Df(3R)ED6025)

(Ogi et al., 2019)

viable (with Df(3R)ED6027)

(Ogi et al., 2019)

viable (with Df(3R)ED10811)

(Ogi et al., 2019)

viable (with Df(3R)ED10820)

(Ogi et al., 2019)

viable (with Df(3R)Exel6184)

(Ogi et al., 2019)

viable (with Df(3R)Exel6185)

(Ogi et al., 2019)

viable (with Df(3R)Exel6272)

(Ogi et al., 2019)

Phenotype Manifest In

eye photoreceptor cell stalk | adult stage

(Ogi et al., 2019)

eye photoreceptor cell stalk | pupal stage (with Df(3R)BSC43)

(Ogi et al., 2019)

outer photoreceptor cell | adult stage

(Ogi et al., 2019)

outer photoreceptor cell | adult stage | somatic clone

(Ogi et al., 2019)

outer photoreceptor cell | pupal stage (with Df(3R)BSC43)

(Ogi et al., 2019)

outer photoreceptor cell | pupal stage (with Synd^mut1)

(Ogi et al., 2019)

outer photoreceptor cell | pupal stage | somatic clone

(Ogi et al., 2019)

rhabdomere microvillus | adult stage

(Ogi et al., 2019)

rhabdomere microvillus | pupal stage (with Df(3R)BSC43)

(Ogi et al., 2019)

rhabdomere of eye photoreceptor cell | adult stage

(Ogi et al., 2019)

rhabdomere of eye photoreceptor cell | adult stage | somatic clone

(Ogi et al., 2019)

rhabdomere of eye photoreceptor cell | pupal stage (with Df(3R)BSC43)

(Ogi et al., 2019)

rhabdomere of eye photoreceptor cell | pupal stage (with Synd^mut1)

(Ogi et al., 2019)

rhabdomere of eye photoreceptor cell | pupal stage | somatic clone

(Ogi et al., 2019)

Detailed Description

Statement

Reference

In pupal and adult Synd^661T homozygous mosaic retinas, ommatidia composed of only mutant photoreceptors exhibit C-shaped (fused) peripheral photoreceptor rhabdomeres when compared to controls. In pupal mosaic retinas, all mutant photoreceptors, as well as control photoreceptors neighboring mutant photoreceptors show irregularly rhabdomeres, while most control photoreceptors show the rhabdoemres with the expected round-shape.

In adult Synd^661T homozygotes the apical membrane domains of photoreceptors (stalks and rhabdomeres) are disrupted, microvilli of each photoreceptor are not united into a single round rhabdomere, and the catacomb-like membrane architecture is absent, while the basolateral membrane, adherens junctions and cytoplasmic organelles (such as Golgi units and mitochondria) exhibit similar structures when compared to controls. In Synd^661T/Df(3R)BSC43 pupae stalk-rhabdomere segregation is also disrupted when compared to controls.

In pupal ommatidia, the heteroallelic combination of Synd^661T with Df(3R)BSC43 or Synd^mut1 leads to C-shaped peripheral photoreceptor rhabdomeres while Synd^661T heterozygosity or the heteroallelic combination of Synd^661T with Df(3R)BSC124, Df(3R)BSC141, Df(3R)BSC475, Df(3R)BSC488, Df(3R)BSC516, Df(3R)BSC517, Df(3R)BSC518, Df(3R)BSC680, Df(3R)BSC808, Df(3R)BSC809, Df(3R)BSC818, Df(3R)BSC819, Df(3R)ED10811, Df(3R)ED10820, Df(3R)ED5942, Df(3R)ED6025, Df(3R)ED6027, Df(3R)Exel6184, Df(3R)Exel6185 or Df(3R)Exel6272 does not lead to any alteration in pupal rhabdomare morphology when compared to controls.

(Ogi et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Synd^661T has abnormal neuroanatomy | pupal stage | somatic clone phenotype, enhanceable by chp²/chp²

(Ogi et al., 2019)

Synd^661T has abnormal neuroanatomy | adult stage | somatic clone phenotype, enhanceable by chp²/chp²

(Ogi et al., 2019)

NOT Enhanced by

Statement

Reference

Synd^661T has abnormal neuroanatomy | pupal stage | somatic clone phenotype, non-enhanceable by Moe^PL54/Moe^PL54

(Ogi et al., 2019)

Synd^661T has abnormal neuroanatomy | adult stage phenotype, non-enhanceable by Moe^PL54/Moe^PL54

(Ogi et al., 2019)

NOT suppressed by

Statement

Reference

Synd^661T has abnormal neuroanatomy | somatic clone | pupal stage phenotype, non-suppressible by Moe^PL54/Moe^PL54

(Ogi et al., 2019)

Synd^661T has abnormal neuroanatomy | adult stage phenotype, non-suppressible by Moe^PL54/Moe^PL54

(Ogi et al., 2019)

NOT Enhancer of

Statement

Reference

Synd^661T is a non-enhancer of abnormal neuroanatomy | pupal stage | somatic clone phenotype of Moe^PL54

(Ogi et al., 2019)

Synd^661T is a non-enhancer of abnormal neuroanatomy | adult stage phenotype of Moe^PL54

(Ogi et al., 2019)

NOT Suppressor of

Statement

Reference

Synd^661T is a non-suppressor of abnormal neuroanatomy | somatic clone | pupal stage phenotype of Moe^PL54

(Ogi et al., 2019)

Synd^661T is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Moe^PL54

(Ogi et al., 2019)

Other

Statement

Reference

Synd^661T, chp² has abnormal neuroanatomy | somatic clone | pupal stage phenotype

(Ogi et al., 2019)

Phenotype Manifest In

Enhanced by

Statement

Reference

Synd^661T has rhabdomere of eye photoreceptor cell | pupal stage | somatic clone phenotype, enhanceable by chp²/chp²

(Ogi et al., 2019)

Synd^661T has outer photoreceptor cell | pupal stage | somatic clone phenotype, enhanceable by chp²/chp²

(Ogi et al., 2019)

Synd^661T has eye photoreceptor cell stalk | pupal stage | somatic clone phenotype, enhanceable by chp²/chp²

(Ogi et al., 2019)

Synd^661T has rhabdomere of eye photoreceptor cell | adult stage | somatic clone phenotype, enhanceable by chp²/chp²

(Ogi et al., 2019)

Synd^661T has outer photoreceptor cell | adult stage | somatic clone phenotype, enhanceable by chp²/chp²

(Ogi et al., 2019)

NOT Enhanced by

Statement

Reference

Synd^661T has rhabdomere of eye photoreceptor cell | pupal stage | somatic clone phenotype, non-enhanceable by Moe^PL54/Moe^PL54

(Ogi et al., 2019)

Synd^661T has eye photoreceptor cell stalk | adult stage phenotype, non-enhanceable by Moe^PL54/Moe^PL54

(Ogi et al., 2019)

Synd^661T has rhabdomere of eye photoreceptor cell | adult stage phenotype, non-enhanceable by Moe^PL54/Moe^PL54

(Ogi et al., 2019)

Synd^661T has eye photoreceptor cell stalk | pupal stage | somatic clone phenotype, non-enhanceable by Moe^PL54/Moe^PL54

(Ogi et al., 2019)

Synd^661T has outer photoreceptor cell | pupal stage | somatic clone phenotype, non-enhanceable by Moe^PL54/Moe^PL54

(Ogi et al., 2019)

Synd^661T has outer photoreceptor cell | adult stage phenotype, non-enhanceable by Moe^PL54/Moe^PL54

(Ogi et al., 2019)

NOT suppressed by

Statement

Reference

Synd^661T has rhabdomere of eye photoreceptor cell | somatic clone | pupal stage phenotype, non-suppressible by Moe^PL54/Moe^PL54

(Ogi et al., 2019)

Synd^661T has eye photoreceptor cell stalk | adult stage phenotype, non-suppressible by Moe^PL54/Moe^PL54

(Ogi et al., 2019)

Synd^661T has rhabdomere of eye photoreceptor cell | adult stage phenotype, non-suppressible by Moe^PL54/Moe^PL54

(Ogi et al., 2019)

Synd^661T has eye photoreceptor cell stalk | somatic clone | pupal stage phenotype, non-suppressible by Moe^PL54/Moe^PL54

(Ogi et al., 2019)

Synd^661T has outer photoreceptor cell | somatic clone | pupal stage phenotype, non-suppressible by Moe^PL54/Moe^PL54

(Ogi et al., 2019)

Synd^661T has outer photoreceptor cell | adult stage phenotype, non-suppressible by Moe^PL54/Moe^PL54

(Ogi et al., 2019)

NOT Enhancer of

Statement

Reference

Synd^661T is a non-enhancer of rhabdomere of eye photoreceptor cell | pupal stage | somatic clone phenotype of Moe^PL54

(Ogi et al., 2019)

Synd^661T is a non-enhancer of eye photoreceptor cell stalk | adult stage phenotype of Moe^PL54

(Ogi et al., 2019)

Synd^661T is a non-enhancer of rhabdomere of eye photoreceptor cell | adult stage phenotype of Moe^PL54

(Ogi et al., 2019)

Synd^661T is a non-enhancer of eye photoreceptor cell stalk | pupal stage | somatic clone phenotype of Moe^PL54

(Ogi et al., 2019)

Synd^661T is a non-enhancer of outer photoreceptor cell | pupal stage | somatic clone phenotype of Moe^PL54

(Ogi et al., 2019)

Synd^661T is a non-enhancer of outer photoreceptor cell | adult stage phenotype of Moe^PL54

(Ogi et al., 2019)

NOT Suppressor of

Statement

Reference

Synd^661T is a non-suppressor of rhabdomere of eye photoreceptor cell | somatic clone | pupal stage phenotype of Moe^PL54

(Ogi et al., 2019)

Synd^661T is a non-suppressor of eye photoreceptor cell stalk | adult stage phenotype of Moe^PL54

(Ogi et al., 2019)

Synd^661T is a non-suppressor of rhabdomere of eye photoreceptor cell | adult stage phenotype of Moe^PL54

(Ogi et al., 2019)

Synd^661T is a non-suppressor of eye photoreceptor cell stalk | somatic clone | pupal stage phenotype of Moe^PL54

(Ogi et al., 2019)

Synd^661T is a non-suppressor of outer photoreceptor cell | somatic clone | pupal stage phenotype of Moe^PL54

(Ogi et al., 2019)

Synd^661T is a non-suppressor of outer photoreceptor cell | adult stage phenotype of Moe^PL54

(Ogi et al., 2019)

Other

Statement

Reference

Synd^661T, chp² has rhabdomere of eye photoreceptor cell | somatic clone | pupal stage phenotype

(Ogi et al., 2019)

Synd^661T, chp² has eye photoreceptor cell stalk | somatic clone | pupal stage phenotype

(Ogi et al., 2019)

Synd^661T, chp² has outer photoreceptor cell | somatic clone | pupal stage phenotype

(Ogi et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

In pupal and adult Moe^PL54 mosaic retinas on a Synd^661T/Df(3R)BSC43 background the extent of stalk-rhabdomere segregation defect is not different than Synd^661T homozygous mosaic retinas.

In photoreceptor cells of chp² and Synd^661T double homozygous mosaic retinas during pupal stages the stalk-rhabdomere separation is severely and prominently disrupted (even before catacomb-like membrane architecture formation); in adults microvilli show no co-adherence instead spread across the entire apical membrane adult mosaic retina when compared to controls.

(Ogi et al., 2019)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Synd^661T is rescued by Synd^UAS.cUa

(Ogi et al., 2019)

Comments

Expression of Synd^UAS.cUa starting from early pupal development under the control of Scer\GAL4^hs.PU rescues the C-shaped rhabdomere phenoype of Synd^661T homozygous mosaic retinas while its late expression (starting from mid or late pupal development) under the control of Scer\GAL4^hs.PU or Scer\GAL4^ninaE.PU fails to rescue the same phenotype.

(Ogi et al., 2019)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Synd^661T

(Ogi et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (1)

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