FlyBase Allele Report: Dmel\sna[Sco]

General Information

Symbol

Dmel\sna^Sco

Species

D. melanogaster

Name

Scutoid

FlyBase ID

FBal0246852

Feature type

allele

Associated gene

Dmel\sna

Associated Insertion(s)

Carried in Construct

Also Known As

Sco

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Krivshenko, 1959)

Progenitor genotype

Caused by aberration

Tp(2;2)Sco

Cytology

Associated with a pair of reciprocal transpositions that are tentatively postulated to result from a pair of inversions, one included within the other. Based on reversion analysis Sco postulated to result from the juxtaposition of noc⁺ and sna⁺ at the 34A5/35D1 junction.

Description

-24.6 to -107.8. From the molecular map of the wild-type noc-Adh region (McGill, Chia, Karp and Ashburner, 1988); coordinate 0 an EcoRI restriction site 1321 bp to the left of the start of transcription of the larval Adh transcript; '+' values to the right, '-' values to the left.

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Krivshenko, 1959)

visible | dominant

(Fuse et al., 1999, Sur et al., 1995, Krivshenko, 1959)

Phenotype Manifest In

Detailed Description

Statement

Reference

sna^Sco/+ flies lack the anterior scutellar and posterior scutellar bristles. The regular array of ommatidia in the eye is disturbed and the number of ommatidia is reduced by about 8.8%. The number of interommatidial bristles is reduced by 51.2%.

(Fuse et al., 1999)

Heterozygotes show loss of 100-15 bristles on the thorax, the scutellars, notopleurals, upper humerals and anterior postalars being most frequently affected.

(Sur et al., 1995)

sna^Sco/+ flies have 25-27 dorsal head and thoracic bristles.

Enhanced by noc^TE35B; noc^Sco/noc^TE35B flies have only about 16 dorsal head and thoracic bristles, compared to 25-27 bristles in noc^Sco/+ heterozygotes.

(Gubb et al., 1986)

Heterozygotes lack all scutellar bristles. One or both postscutellar bristles are sometimes present, but they are shorter and thinner than normal. The ocellar and humeral bristles are often absent. Heterozygotes have good viability and fertility.

(Krivshenko, 1959)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

sna^Sco has visible | dominant phenotype, enhanceable by z¹

(Fuse et al., 1999)

sna^Sco has visible | dominant phenotype, enhanceable by z^a

(Fuse et al., 1999)

sna^Sco has visible | dominant phenotype, enhanceable by z^ae(bx)

(Fuse et al., 1999)

Enhancer of

Statement

Reference

sna^Sco is an enhancer of visible phenotype of H^UAS.cMa, Scer\GAL4^GMR.PU

(Protzer et al., 2009)

Other

Statement

Reference

smi26D¹/smi26D[+], sna^Sco has abnormal smell perception | dominant | male phenotype

(Anholt et al., 2003)

smi21F[+]/Pino^smi21F, sna^Sco has abnormal smell perception | dominant | male phenotype

(Anholt et al., 2003)

Pino^smi21F, sna^Sco has abnormal smell perception | dominant | male phenotype

(Anholt et al., 2003)

smi26D¹, sna^Sco has abnormal smell perception | dominant | male phenotype

(Anholt et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

sna^Sco has phenotype, enhanceable by elB^EP2039

(Ashburner et al., 1999)

sna^Sco has macrochaeta phenotype, enhanceable by z^ae(bx)

(Fuse et al., 1999)

sna^Sco has macrochaeta phenotype, enhanceable by z¹

(Fuse et al., 1999)

sna^Sco has macrochaeta phenotype, enhanceable by z^a

(Fuse et al., 1999)

sna^Sco has chaeta phenotype, enhanceable by noc^TE35B

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by elA¹²

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by elA²³

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by elA²⁶

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by elA²⁷

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by elB¹²

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by elB²³

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by elB²⁶

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by elB²⁷

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by elB²

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by elB³

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by elB⁴

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by elB⁵

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by elB⁶

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by elB⁷

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by elB⁹

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by noc^GT8

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by noc⁷

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by noc⁴

(Davis et al., 1997)

sna^Sco has chaeta phenotype, enhanceable by noc²

(Davis et al., 1997)

sna^Sco has adult head bristle | dorsal phenotype, enhanceable by noc^TE35B

(Gubb et al., 1986)

NOT Enhanced by

Statement

Reference

sna^Sco has phenotype, non-enhanceable by elA²⁴

(Davis, 2003.5.6)

Enhancer of

Statement

Reference

sna^Sco is an enhancer of eye phenotype of H^UAS.cMa, Scer\GAL4^GMR.PU

(Protzer et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

sna^Sco enhances the small, rough eye phenotype caused by expression of H^Scer\UAS.cMa under the control of Scer\GAL4^GMR.PU.

(Protzer et al., 2009)

The sna^Sco/+ loss of macrochaetae phenotype is significantly enhanced by z^a, z^ae(bx) or z¹.

(Fuse et al., 1999)

The sna^Sco bristle phenotype is unaffected by elA¹, elA⁸, elB⁸, elA¹⁰, elB¹⁰, elA¹¹, elB¹¹, elA¹³, elB¹³, elA²¹, elB²¹, elA²², elB²², elA²⁴, elA²⁵, elB²⁵, elA²⁹, elB²⁹, T(Y;2)GT1 and T(2;3)Mpe.

The noc^Sco bristle phenotype is unaffected by elA¹, elA⁸, elB⁸, elA¹⁰, elB¹⁰, elA¹¹, elB¹¹, elA¹³, elB¹³, elA²¹, elB²¹, elA²², elB²², elA²⁴, elA²⁵, elB²⁵, elA²⁹, elB²⁹, T(Y;2)GT1 and T(2;3)Mpe.

(Davis et al., 1997)

Enhanced by noc^TE35B; the number of dorsal head and thoracic bristles seen in sna^Sco/noc^TE35B flies is reduced to approximately 16, compared to 25-27 in sna^Sco/+ flies.

(Gubb et al., 1986)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (358)

Bloomington

2555

CyO/sna^Sco

2551

CyO/sna^Sco; TM6/MRS

6226

Df(2L)pr76, sna^Sco/CyO

404

sna^Sco Bl¹/CyO

503

sna^Sco/CyO; eyg¹

6311

sna^Sco/CyO, P{sevRas1.V12}FK1

2392

l(2)DTS91¹ sna^Sco/CyO

3786

Df(2L)VA23, sna^Sco pr¹/CyO

Kyoto

107400

CyO/sna^Sco

108687

Df(2L)pr76, sna^Sco/CyO

101837

w¹ ; sna^Sco / CyO

107305

l(2)DTS91¹ sna^Sco/CyO

More stocks available...

Notes on Origin

Discoverer

Krivshenko, 15th Dec. 1956.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Sco

(Birkholz et al., 2004, Davis, 2003.5.6, Ashburner et al., 1999, Fuse et al., 1999, Davis et al., 1997, Hekmat-Scafe and Carlson, 1996, Sur et al., 1995, Gubb et al., 1986, Krivshenko, 1959)

Sco¹

(Protzer et al., 2009)

noc^Sco

(Cook and Cook, 2010.2.17, Elsaesser et al., 2010)

sna^Sco

(Arbouzova et al., 2019, Park et al., 2014, Richter et al., 2011)

sna^sco

(Titus et al., 2023)

Name Synonyms

Scutoid

(Park et al., 2014, Sur et al., 1995)

Secondary FlyBase IDs

FBal0013044
FBal0102398

References (25)

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