FB2024_03 , released June 25, 2024
Aberration: Dmel\Tp(2;2)Sco
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General Information
Symbol
Tp(2;2)Sco
Species
D. melanogaster
Name
Transposition (2;2) Scutoid
FlyBase ID
FBab0009769
Feature type
intrachromosomal_transposition
Also Known As
Sco
Computed Breakpoints include

35B1;35B3;35C1;35D1-35D2

Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order

2Lt - 35A4 | (35C2 - 35C5) | 35B4 - 35C1 | 35B3 - 35B1 | 35D1 - 2Rt

2Lt - 35A4 | (35C1 - 35C4) | 35B4 - 35B10 | 35B3 - 35B1 | 35D2 - 2Rt

(Ashburner et al., 1983)

2Lt - 35A4 | 35C2 - 35C5 | 35B4 - 35C1 | 35B3 - 35B1 | 35D2 - 2Rt

(Ashburner and Harrington, 1984)

2Lt - 35B | (35D - 35D) | 35B - 35D | 35B - 35B | 35D - 2Rt

(Dubin et al., 1995)
Progenitor
Mutagen
X ray
(Dubin et al., 1995, Grau et al., 1984)
Class of aberration (relative to wild type)
intrachromosomal_transposition
Class of aberration (relative to progenitor)
Breakpoints

35A4-35B1;35B3-35B4;35B10-35C1;35C4-35D2

(Ashburner et al., 1983)

35A4-35B1;35B3-35B4;35C1-35C2;35C5-35D2

(Ashburner and Harrington, 1984)

[];35B1--3;[];35D1--2

(Gubb et al., 1990)

35B;35B;35D;35D

(Dubin et al., 1995)

35A4-35B1;35B3;35B10-35C1;35D1-35D2

(Roote et al., 1996)
Causes alleles
snaSco
(Ashburner et al., 1999.10.12, Fuse et al., 1999, Ashburner et al., 1983)
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 hits noc << Adhr << bk2 << mol << stc << bk3 << wor << bk4 << sna

Genetic mapping information
Comments

Adh-noc region cloned (Chia, Karp, McGill and Ashburner, 1985, J. Mol. Biol 186: 689-706) (coordinate 0 an EcoRI restriction site 1321 bp to the left of the start of transcription of the larval Adh transcript; positive values toward the centromere). The distal breakpoint of the Sco rearrangement is within the noc gene complex between the nocA and nocB components, such that nocB and nocC are brought into juxtaposition with sna. The molecular coordinates are complex, in that the distal break point as judged from the uninverted portion of noc is between coordinates -103.3 and -102.3; as judged from the noc-sna junction, however, it is between coordinates -108.5 and -107.8 kb, very close to the -107.8 position. Both these breakpoints are between nocA and nocB; the noc-Adh transposed segment extends from -107.8 to at least +40 kb (McGill, Chia, Karp and Ashburner, 1988, Genetics 119: 647-61). The proximal-most breakpoint of Tp(2;2)Sco is within 16 kb to the left of sna (Alberga).

Comments on Cytology

noc-Adh region is inverted and inserted next to sna.

(Dubin et al., 1995)

Synapsis disturbed in 35 (FBrf0038047).

(Grau et al., 1984)

Left limit of break 1 from polytene analysis (FBrf0083878) Right limit of break 1 from polytene analysis (FBrf0039455) Left limit of break 2 from polytene analysis (FBrf0039455) Right limit of break 2 from polytene analysis (FBrf0051930) Left limit of break 3 from polytene analysis (FBrf0040522) Right limit of break 3 from polytene analysis (FBrf0039455) Left limit of break 4 from polytene analysis (FBrf0051930) Right limit of break 4 from polytene analysis (FBrf0039455)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
sna
(Fuse et al., 1999)
Partially deleted / disrupted
noc
(Roote et al., 1996)
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Adh
(Roote, 2002.1.15)
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations
    NOT in combination with other aberrations

    Adult flies have dramatically reduced extracellularly recorded olfactory response to short chain but not long chain acetate esters and ketones. Mutation causes a decrease in the maximal response to the odours and not a change in their apparent affinity. Adult visual responses and larval attraction to short chain esters and ketones are not altered. Antenna shows no obvious structural abnormalities.

    (Dubin et al., 1995)

    Chromosome has no effect on the physical interaction between tandemly duplicated copies of w+ and z1, despite having breakpoints within the critical region.

    (Gubb et al., 1990)

    homozygous lethal Sco phenotype enhanced by noc mutations and suppressed by noc+ duplications.

    Stocks (0)
    Notes on Origin
    Discoverer

    Krivshenko, 15th Dec. 1956.

     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
    Other Comments
     
    Synonyms and Secondary IDs (10)
    Reported As
    Symbol Synonym
    Dp(2;2)Sco-1
    (Gubb et al., 1984)
    Sco
    (Birkholz et al., 2003, Minden, 1996, Dubin et al., 1995, Grau et al., 1984, Ashburner et al., 1981, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
    Tp(2)Sco
    (Ashburner, 1982)
    Tp(2;2)Sco
    Tp(2;2)Sco-1
    (Roote, 2002.1.15)
    Tp(2;2)Sco1
    (Gubb et al., 1990)
    Tp(2;2)Sco1 Tp(2;2)Sco2
    Name Synonyms
    Transposition (2;2) Scutoid
    lethal 1 in the black-reduced region
    (Woodruff and Ashburner, 1979)
    lethal 22 in the black-reduced region
    (Woodruff and Ashburner, 1979)
    Secondary FlyBase IDs
      References (25)