FlyBase Allele Report: Dmel\Pino[smi21F]

General Information

Symbol

Dmel\Pino^smi21F

Species

D. melanogaster

Name

FlyBase ID

FBal0050507

Feature type

allele

Associated gene

Dmel\Pino

Associated Insertion(s)

P{lArB}Pino^smi21F

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Rollmann et al., 2005)

Mutagen

Delta2-3 transposase

(Anholt et al., 1996)

Progenitor genotype

Associated Insertion(s)

P{lArB}Pino^smi21F

Cytology

Description

P{lArB} insertion within Pino, within intron 2 of isoform I and upstream of the transcription initiation site of isoform II.

(Rollmann et al., 2005)

P{lArB} insertion in the second intron.

(Anholt et al., 2003)

Allele components

Component

Use(s)

Inserted element

P{lArB}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | recessive

(Anholt et al., 1996)

abnormal neurophysiology

(Rollmann et al., 2005)

abnormal smell perception

(Fedorowicz et al., 1998)

abnormal smell perception (with Df(2L)ast2)

(Rollmann et al., 2005)

abnormal smell perception | female

(Rollmann et al., 2005)

abnormal smell perception | male

(Rollmann et al., 2005)

Phenotype Manifest In

antenna

(Rollmann et al., 2005)

Detailed Description

Statement

Reference

Mutant flies show no statistically difference in their attractant response to ethyl propionate, acetaldehyde or acetal in an olfactory trap assay compared to wild-type flies.

The attractant response to acetic acid is reduced in mutant females in an olfactory trap assay compared to wild-type flies.

The attractant response to propionic acid is reduced in mutant males in an olfactory trap assay compared to wild-type flies.

Electroantennogram peak amplitudes in response to ethyl acetate, benzaldehyde or ethyl propionate are greater for both males and females in mutant flies than in controls.

(Rollmann et al., 2005)

Olfaction defective as measured in a dipstick assay using 1% benzaldehyde.

(Fedorowicz et al., 1998)

Shows normal olfactory behavior when tested with 2-n-propylpyrazine, but females respond poorly to 2-isobutylthiazole and low concentrations of benzaldehyde.

(Anholt et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Hk¹, smi21F[+]/Pino^smi21F has abnormal smell perception | dominant | male phenotype

(Anholt et al., 2003)

smi21F[+]/Pino^smi21F, amos^Roi-1 has abnormal smell perception | dominant | female phenotype

(Anholt et al., 2003)

smi21F[+]/Pino^smi21F, sna^Sco has abnormal smell perception | dominant | male phenotype

(Anholt et al., 2003)

PPO1^UAS.cTa, Pino^smi21F, Scer\GAL4^unspecified has abnormal smell perception | dominant | female phenotype

(Anholt et al., 2003)

Pino^smi21F, amos^Roi-1 has abnormal smell perception | dominant | female phenotype

(Anholt et al., 2003)

Hk¹, Pino^smi21F has abnormal smell perception | dominant | male phenotype

(Anholt et al., 2003)

Pino^smi21F, fax^BG00833 has abnormal smell perception | dominant | male phenotype

(Anholt et al., 2003)

Pino^smi21F, sna^Sco has abnormal smell perception | dominant | male phenotype

(Anholt et al., 2003)

smi21F[+]/Pino^smi21F, fax^BG00833 has abnormal smell perception | dominant | male phenotype

(Anholt et al., 2003)

PPO1^UAS.cTa, smi21F[+]/Pino^smi21F, Scer\GAL4^unspecified has abnormal smell perception | dominant | female phenotype

(Anholt et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

Pino^smi21F has phenotype, enhanceable by smi26D¹

(Fedorowicz et al., 1998)

Pino^smi21F has phenotype, enhanceable by smi27E¹

(Fedorowicz et al., 1998)

Suppressed by

Statement

Reference

Pino^smi21F has phenotype, suppressible by smi45E¹

(Fedorowicz et al., 1998)

Pino^smi21F has phenotype, suppressible by scrib^smi97B

(Fedorowicz et al., 1998)

Enhancer of

Statement

Reference

Pino^smi21F is an enhancer of phenotype of smi26D¹

(Fedorowicz et al., 1998)

Pino^smi21F is an enhancer of phenotype of smi27E¹

(Fedorowicz et al., 1998)

Suppressor of

Statement

Reference

Pino^smi21F is a suppressor of phenotype of scrib^smi97B

(Fedorowicz et al., 1998)

Pino^smi21F is a suppressor of phenotype of smi45E¹

(Fedorowicz et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Precise excision of the P{lArB} element restores a wild-type olfactory avoidance response to 0.3% benzaldehyde.

(Rollmann et al., 2005)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Pino^smi21F

(Rollmann et al., 2005)

smi21F

(Anholt et al., 2003)

smi21F¹

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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