FlyBase Allele Report: Dmel\dx[152]

General Information

Symbol

Dmel\dx¹⁵²

Species

D. melanogaster

Name

FlyBase ID

FBal0217806

Feature type

allele

Associated gene

Dmel\dx

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Fuwa et al., 2006)

Mutagen

Delta2-3 transposase

(Fuwa et al., 2006)

Progenitor genotype

P{EP}dx^Δ64

(Fuwa et al., 2006)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a 2795bp deletion 3' to the original insertion site.

(Fuwa et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:6,534,117..6,536,911 [+]

Comment:

2795 bp deletion resulting from the imprecise excision of P{EP}dx^Delta64.

(Fuwa et al., 2006)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Fuwa et al., 2006)

viable

(Fuwa et al., 2006)

visible

(Kankel et al., 2007)

visible (with Df(1)dx81)

(Fuwa et al., 2006)

visible (with dx¹)

(Fuwa et al., 2006)

visible (with dx²⁴)

(Fuwa et al., 2006)

visible (with dx^ENU)

(Fuwa et al., 2006)

visible | adult stage | male

(Sachan et al., 2013)

visible | recessive

(Fuwa et al., 2006)

Phenotype Manifest In

interocellar bristle

(Fuwa et al., 2006)

ocellus

(Fuwa et al., 2006)

ommatidium

(Fuwa et al., 2006)

photoreceptor cell R3 | ectopic

(Fuwa et al., 2006)

photoreceptor cell R4

(Fuwa et al., 2006)

wing

(Kankel et al., 2007, Fuwa et al., 2006)

wing (with Df(1)dx81)

(Fuwa et al., 2006)

wing (with dx¹)

(Fuwa et al., 2006)

wing (with dx²⁴)

(Fuwa et al., 2006)

wing (with dx^ENU)

(Fuwa et al., 2006)

wing vein

(Kankel et al., 2007, Fuwa et al., 2006)

wing vein (with Df(1)dx81)

(Fuwa et al., 2006)

wing vein (with dx¹)

(Fuwa et al., 2006)

wing vein (with dx²⁴)

(Fuwa et al., 2006)

wing vein (with dx^ENU)

(Fuwa et al., 2006)

wing vein | male

(Sachan et al., 2013)

Detailed Description

Statement

Reference

One copy of dx¹⁵² has no effect on eye size.

(Surabhi et al., 2015)

dx¹⁵² hemizygous adult males (but not heterozygous females) display vein deltas in the wing.

(Sachan et al., 2013)

Hemizygotes show distal wing vein thickening with occasional wing notching.

(Kankel et al., 2007)

Homozygotes and hemizygotes are viable and fertile. They show wing vein thickening in 100% of cases, and a notch at the wing tip in 5% of cases.

dx^ENU/dx¹⁵² and dx²⁴/dx¹⁵² flies show wing vein thickening.

dx¹/dx¹⁵² flies show wing vein thickening and can show wing notching.

Homozygotes show a mild rotation defect in the ommatidia and some symmetrical R3/R3 ommatidia being seen. Photoreceptor cell number is normal.

Interocellar bristles are disorganised in 70% of homozygotes and fusion of the ocelli is seen in 2% of cases.

Mutants have normal legs, macrochaetae and microchaetae.

(Fuwa et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dx¹⁵² has visible | adult stage | male phenotype, enhanceable by Kap-α3^D93

(Sachan et al., 2013)

dx¹⁵² has visible | adult stage | male phenotype, enhanceable by Kap-α3^D165

(Sachan et al., 2013)

dx¹⁵² has visible | adult stage | male phenotype, enhanceable by Kap-α3^S033513

(Sachan et al., 2013)

dx¹⁵² has visible phenotype, enhanceable by sca[+]/sca^d09400

(Kankel et al., 2007)

dx¹⁵² has visible phenotype, enhanceable by klu^d00059/klu[+]

(Kankel et al., 2007)

dx¹⁵² has visible phenotype, enhanceable by GPHR^c06331/CG8090[+]

(Kankel et al., 2007)

dx¹⁵² has visible | recessive phenotype, enhanceable by Delta^RevF10/Dl[+]

(Fuwa et al., 2006)

Suppressed by

Statement

Reference

dx¹⁵² has visible phenotype, suppressible by f06222^f06222/f06222[+]

(Kankel et al., 2007)

dx¹⁵² has visible | recessive phenotype, suppressible by Su(H)[+]/Su(H)^del47

(Fuwa et al., 2006)

dx¹⁵² has visible | recessive phenotype, suppressible by Su(H)[+]/Su(H)^T4

(Fuwa et al., 2006)

Suppressor of

Statement

Reference

dx¹⁵²/dx[+] is a suppressor | partially of visible phenotype of Scer\GAL4^ey.PU, mahe^UAS.Tag:HA

(Surabhi et al., 2015)

dx¹⁵²/dx[+] is a suppressor of visible | dominant phenotype of N^Ax-E2

(Fuwa et al., 2006)

Other

Statement

Reference

Su(H)[+]/Su(H)^T4, dx¹⁵² has partially lethal - majority die phenotype

(Fuwa et al., 2006)

Ser^CS94/Ser[+], dx¹⁵² has lethal phenotype

(Fuwa et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

dx¹⁵² has wing vein | male phenotype, enhanceable by Kap-α3^D93

(Sachan et al., 2013)

dx¹⁵² has wing vein | male phenotype, enhanceable by Kap-α3^D165

(Sachan et al., 2013)

dx¹⁵² has wing vein | male phenotype, enhanceable by Kap-α3^S033513

(Sachan et al., 2013)

dx¹⁵² has wing vein phenotype, enhanceable by sca[+]/sca^d09400

(Kankel et al., 2007)

dx¹⁵² has wing vein phenotype, enhanceable by klu^d00059/klu[+]

(Kankel et al., 2007)

dx¹⁵² has wing phenotype, enhanceable by klu^d00059/klu[+]

(Kankel et al., 2007)

dx¹⁵² has wing vein phenotype, enhanceable by GPHR^c06331/CG8090[+]

(Kankel et al., 2007)

dx¹⁵² has wing phenotype, enhanceable by Su(H)[+]/Su(H)^T4

(Fuwa et al., 2006)

dx¹⁵² has wing vein phenotype, enhanceable by Delta^RevF10/Dl[+]

(Fuwa et al., 2006)

dx¹⁵² has ocellus phenotype, enhanceable by Delta^RevF10/Dl[+]

(Fuwa et al., 2006)

Suppressed by

Statement

Reference

dx¹⁵² has wing vein phenotype, suppressible by f06222^f06222/f06222[+]

(Kankel et al., 2007)

dx¹⁵² has wing vein phenotype, suppressible by Su(H)[+]/Su(H)^del47

(Fuwa et al., 2006)

Suppressor of

Statement

Reference

dx¹⁵²/dx[+] is a suppressor | partially of eye phenotype of Scer\GAL4^ey.PU, mahe^UAS.Tag:HA

(Surabhi et al., 2015)

dx¹⁵²/dx[+] is a suppressor of wing vein L5 | distal phenotype of N^Ax-E2

(Fuwa et al., 2006)

Other

Statement

Reference

Delta^RevF10/Dl[+], dx¹⁵² has prothoracic tarsal segment 2 phenotype

(Fuwa et al., 2006)

Delta^RevF10/Dl[+], dx¹⁵² has prothoracic tarsal segment 3 phenotype

(Fuwa et al., 2006)

Su(H)[+]/Su(H)^T4, dx¹⁵² has prothoracic tarsal segment 4 phenotype

(Fuwa et al., 2006)

Su(H)[+]/Su(H)^T4, dx¹⁵² has prothoracic tarsal segment 5 phenotype

(Fuwa et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of dx¹⁵² marginally suppresses the reduced eye phenotype seen when mahe^{Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^ey.PU in 32% of eyes examined.

(Surabhi et al., 2015)

The wing vein deltas and extra vein material observed in dx¹⁵² hemizygous adult males is exacerbated by combination with single copy of any of the following alleles: Kap-α3^D93, Kap-α3^D165 or Kap-α3^S033513. No wing defects are observed in adult females double heterozygote for dx¹⁵² and any of the aforementioned Kap-α3 alleles.

(Sachan et al., 2013)

The wing vein defects of dx¹⁵² hemizygotes are enhanced by one copy of sca^d09400, klu^d00059 or CG8090^c06331. For klu^d00059 the degree and penetrance of wing notching is also more severe.

f06222^f06222 completely suppresses the dx¹⁵² wing vein defects.

(Kankel et al., 2007)

The mild wing vein thickening phenotype seen in Df(1)N-54l9/+ flies is enhanced if they are also carrying dx¹⁵²/+.

dx¹⁵²/+ completely suppresses the loss of the distal end of wing vein L5 which is seen in N^Ax-E2/+ flies.

Dl^RevF10/+ enhances the wing vein thickening phenotype of dx¹⁵² hemizygotes. The second and third tarsal segments of the forelegs are fused in 41% of the double mutants, a phenotype that is not seen in either dx¹⁵² hemizygotes or Dl^RevF10/+ animals. The double mutants show fusion of the ocelli in 37% of cases, compared to the 2% penetrance seen in dx¹⁵² hemizygotes.

Su(H)^del47/+ suppresses the wing vein thickening seen in dx¹⁵² hemizygotes.

Su(H)^T4/+ enhances the wing notching defects of dx¹⁵² hemizygotes. The double mutants show semi-lethality. Fusion of the fourth and fifth tarsal segments of the forelegs is seen in 60% of escapers, a phenotype that is not seen in either dx¹⁵² hemizygotes or Su(H)^T4/+ animals.

(Fuwa et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dx¹⁵² is rescued by dx^TX0

(Fuwa et al., 2006)

Comments

dx^TX0 completely rescues the wing, ocellus and ommatidial defects of dx¹⁵² mutants.

(Fuwa et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dx¹⁵²

(Sharma et al., 2022, Baeumers et al., 2020, Shimizu et al., 2017, Surabhi et al., 2015, Sachan et al., 2013, Kankel et al., 2007, Fuwa et al., 2006, Mukherjee et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (8)

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