UASt regulatory sequences drive expression of an inverted repeat.
Expression of Grx1GD10587 driven in the thoracic midline by Scer\GAL4pnr-MD237 causes a thoracic cleft and reduced scutellum, compared to controls. Expression of Grx1GD10587 driven in the eye by Scer\GAL4GMR.PFa causes a mild disruption to the ommatidial array, compared to controls.
Expression under the control of Scer\GAL41407 results in a reduction in the average size of neuroblasts together with shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.
Adults expressing CG6852GD10587 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) show significantly reduced avoidance of noxious temperature (46[o]C) compared to control flies.
Expression under the control of Scer\GAL4Mef2.PR results in late pupal lethality.
Grx1GD10587, Scer\GAL4pnr-MD237 has visible phenotype, enhanceable by Ctr1AGD16726, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has visible phenotype, enhanceable by Ctr1BGD2859, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4GMR.PFa has visible phenotype, enhanceable by Ctr1AGD16726, Scer\GAL4GMR.PFa
Grx1GD10587, Scer\GAL4pnr-MD237 has visible phenotype, enhanceable by ATP7UAS.Tag:FLAG, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has visible phenotype, non-enhanceable by ATP7GD3322, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has visible phenotype, non-enhanceable by Ctr1BUAS.Tag:FLAG, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has visible phenotype, non-suppressible by ATP7GD3322, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has visible phenotype, non-suppressible by Ctr1BUAS.Tag:FLAG, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4GMR.PFa is an enhancer of visible phenotype of Ctr1AGD16726, Scer\GAL4GMR.PFa
Grx1GD10587, Scer\GAL4pnr-MD237 is a non-enhancer of abnormal body color phenotype of ATP7GD3322, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 is a non-suppressor of abnormal body color phenotype of ATP7GD3322, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has scutellum phenotype, enhanceable by ATP7UAS.Tag:FLAG, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has adult thorax phenotype, enhanceable by Ctr1AGD16726, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has scutellum phenotype, enhanceable by Ctr1AGD16726, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has adult thorax phenotype, enhanceable by Ctr1BGD2859, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has scutellum phenotype, enhanceable by Ctr1BGD2859, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4GMR.PFa has eye phenotype, enhanceable by Ctr1AGD16726, Scer\GAL4GMR.PFa
Grx1GD10587, Scer\GAL4pnr-MD237 has adult thorax phenotype, enhanceable by ATP7UAS.Tag:FLAG, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has adult thorax phenotype, non-enhanceable by Ctr1BUAS.Tag:FLAG, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has scutellum phenotype, non-enhanceable by Ctr1BUAS.Tag:FLAG, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has adult thorax phenotype, non-enhanceable by ATP7GD3322, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has scutellum phenotype, non-enhanceable by ATP7GD3322, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has adult thorax phenotype, non-suppressible by ATP7GD3322, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has scutellum phenotype, non-suppressible by ATP7GD3322, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has adult thorax phenotype, non-suppressible by Ctr1BUAS.Tag:FLAG, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4pnr-MD237 has scutellum phenotype, non-suppressible by Ctr1BUAS.Tag:FLAG, Scer\GAL4pnr-MD237
Grx1GD10587, Scer\GAL4GMR.PFa is an enhancer of eye phenotype of Ctr1AGD16726, Scer\GAL4GMR.PFa
Co-expression of ATP7GD3322 along with Grx1GD10587 driven by Scer\GAL4pnr-MD237 results in an additive phenotype, with both thoracic cleft and hypo-pigmentation visible (seen respectively with single expression of Grx1GD10587 or ATP7GD3322) in the adult.
Co-expression of ATP7Scer\UAS.T:Zzzz\FLAG enhances the thoracic cleft and scutellum loss seen in flies with expression of Grx1GD10587 driven by Scer\GAL4pnr-MD237 (compared to expression of either alone).
Co-expression of Ctr1AGD16726 or Ctr1BGD2859 enhances the thoracic cleft and reduced scutellum seen in flies with expression of Grx1GD10587 driven by Scer\GAL4pnr-MD237. Co-expression of Ctr1BScer\UAS.T:Zzzz\FLAG does not alter Scer\GAL4pnr-MD237>Grx1GD10587 phenotypes.
Co-expression of Grx1GD10587 and Ctr1AGD16726 driven by Scer\GAL4GMR.PFa enhances eye phenotypes seen with expression of either alone, with a smaller glazed eye with patches of necrosis and some loss of pigmentation.