FB2024_03 , released June 25, 2024
Allele: Dmel\bchs17
Open Close
General Information
Symbol
Dmel\bchs17
Species
D. melanogaster
Name
FlyBase ID
FBal0193785
Feature type
allele
Associated gene
Dmel\bchs
Associated Insertion(s)
P{EP}EP2299
Carried in Construct
Also Known As
EP(2L)2299, EP(2)2299
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Khodosh et al., 2006)
Mutagen
ethyl methanesulfonate
(Khodosh et al., 2006)
Progenitor genotype
bchsEP2299
(Khodosh et al., 2006)
Associated Insertion(s)
P{EP}EP2299
Cytology
Description

The progenitor P{EP}EP2299 insertion is still present on the chromosome.

(Khodosh et al., 2006)

Amino acid replacement: W2640term.

(Khodosh et al., 2006)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:5,918,161..5,918,161 [+]
Nucleotide change:

G5918161A

Amino acid change:

W2640term | bchs-PA

Reported amino acid change:

W2640term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Khodosh et al., 2006)
transposable_element_insertion_site
2L:5,907,523..5,907,523 [+]
(Khodosh et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      bchs17 mutants show no defects in the larval visual system or embryonic central nervous system.

      (Khodosh et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      bchs17/bchs12 is a suppressor | partially of abnormal neuroanatomy phenotype of Rab1193Bi/Rab11ex1

      (Khodosh et al., 2006)

      Df(2L)cl7/bchs17 is a suppressor | partially of lethal phenotype of Rab1193Bi/Rab11ex1

      (Khodosh et al., 2006)

      bchs17/bchs12 is a suppressor | partially of lethal phenotype of Rab1193Bi/Rab11ex1

      (Khodosh et al., 2006)

      bchs17/bchs[+] is a suppressor | partially of lethal phenotype of Rab1193Bi/Rab11ex1

      (Khodosh et al., 2006)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The viability of Rab11ex1/Rab1193Bi is increased when flies are also mutant for either Df(2L)cl7/bchs17, bchs17/bchs12 or bchs17/+.

      The microchaeta loss of Rab11ex1/Rab1193Bi flies is significantly suppressed by bchs17/+ and is completely suppressed by Df(2L)cl7/bchs17 or bchs17/bchs12. Further, posterior scutellar bristle length of Rab11ex1/Rab1193Bi flies is restored partially by bchs17/+ and more fully by Df(2L)cl7/bchs17 or bchs17/bchs12.

      The bouton density and branching defects of Rab11ex1/Rab1193Bi larval NMJs at muscle 6/7 are significantly suppressed in bchs17/bchs12; Rab11ex1/Rab1193Bi double mutants.

      (Khodosh et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Bchs17
      (Cunningham et al., 2020)
      P{EP}bchs17
      (FlyBase, 1992-)
      bchs17
      (Hebbar et al., 2015, Khodosh et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)