FB2024_03 , released June 25, 2024
Allele: Dmel\Rab11ex1
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General Information
Symbol
Dmel\Rab11ex1
Species
D. melanogaster
Name
FlyBase ID
FBal0135841
Feature type
allele
Associated gene
Dmel\Rab11
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Dollar et al., 2002)
Progenitor genotype
Rab11j2D1
(Dollar et al., 2002)
Cytology
Description

Imprecise excision of the P{lacW} insertion in Rab11j2D1 has created a deletion that removes the second intron of the Rab11 gene.

(Dollar et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Rab11ex1 heterozygous flies show no significant border cell migration defects.

      (Laflamme et al., 2012)

      Rab11ex1/+ flies show no eye phenotype.

      Rab11ex1/Rab1193Bi transheterozygotes are mostly lethal but a few survive to adulthood.

      The posterior abdomens of Rab11ex1/Rab1193Bi flies have empty sockets that are missing microchaetae. Additionally, posterior scutellar bristles are shortened in these mutants.

      The synapse of muscle 6/7 shows an increase in boutons by about 60% in Rab11ex1/Rab1193Bi mutants compared to controls. The boutons of Rab11ex1/Rab1193Bi mutants are often clustered resulting in a 'bunch of grapes' morphology instead of the wild-type 'beads-on-a-string' morphology. The aberrant morphology may reflect increased branching (by 2.6 fold) of Rab11ex1/Rab1193Bi boutons.

      (Khodosh et al., 2006)

      Oogenesis is arrested before oocyte determination in Rab11ex1 germ-line clones.

      (Dollar et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Rab1193Bi/Rab11ex1 has lethal phenotype, suppressible | partially by Df(2L)cl7/bchs17

      (Khodosh et al., 2006)

      Rab1193Bi/Rab11ex1 has lethal phenotype, suppressible | partially by bchs17/bchs12

      (Khodosh et al., 2006)

      Rab1193Bi/Rab11ex1 has lethal phenotype, suppressible | partially by bchs17/bchs[+]

      (Khodosh et al., 2006)

      Rab1193Bi/Rab11ex1 has abnormal neuroanatomy phenotype, suppressible | partially by bchs17/bchs12

      (Khodosh et al., 2006)

      Rab1193Bi/Rab11ex1 has lethal phenotype, suppressible | partially by Df(2L)cl7/+

      (Khodosh et al., 2006)
      Phenotype Manifest In
      Suppressed by
      Enhancer of
      Statement
      Reference

      Rab11[+]/Rab11ex1 is an enhancer of eye phenotype of Scer\GAL4GMR.PF, bchsEP2299

      (Khodosh et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A Rab11ex1 heterozygous background enhances the restriction on border cell migration seen upon expression of Evi5Scer\UAS.T:Disc\RFP-mCherry in border cells under the control of Scer\GAL4c306. The number of clusters unable to initiate migration is strongly increased.

      (Laflamme et al., 2012)

      Rab11ex1 heterozygotes act as dominant enhancers of the Scer\GAL4GMR.PF>bchsEP2299 eye phenotype, resulting in adults with severely reduced eyes.

      The viability of Rab11ex1/Rab1193Bi is increased when flies are also mutant for either Df(2L)cl7/+, Df(2L)cl7/bchs17, bchs17/bchs12 or bchs17/+.

      The microchaeta loss of Rab11ex1/Rab1193Bi flies is significantly suppressed by Df(2L)cl7/+ or bchs17/+ and is completely suppressed by Df(2L)cl7/bchs17 or bchs17/bchs12. Further, posterior scutellar bristle length of Rab11ex1/Rab1193Bi flies is restored partially by Df(2L)cl7/+ or bchs17/+ and more fully by Df(2L)cl7/bchs17 or bchs17/bchs12.

      The bouton density and branching defects of Rab11ex1/Rab1193Bi larval NMJs at muscle 6/7 are significantly suppressed in bchs17/bchs12; Rab11ex1/Rab1193Bi double mutants.

      (Khodosh et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Rab11j2D1

      (Dollar et al., 2002)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rab11ex1
      (Laflamme et al., 2012, Houalla et al., 2010)
      rab11ex1
      (Assaker et al., 2010, Khodosh et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)