FlyBase Allele Report: Dmel\dlp[2]

General Information

Symbol

Dmel\dlp²

Species

D. melanogaster

Name

FlyBase ID

FBal0191142

Feature type

allele

Associated gene

Dmel\dlp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Kirkpatrick et al., 2004)

Mutagen

ethyl methanesulfonate

(Kirkpatrick et al., 2004)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy (with dlp¹)

(Rawson, 2005)

abnormal neuroanatomy | third instar larval stage (with dlp¹)

(Johnson et al., 2006)

abnormal neurophysiology | third instar larval stage (with dlp¹)

(Johnson et al., 2006)

partially lethal - majority die

(Kirkpatrick et al., 2004)

partially lethal - majority die (with Df(3L)fz-D21)

(Kirkpatrick et al., 2004)

segment polarity phenotype (with dlp¹)

(Kirkpatrick et al., 2004)

Phenotype Manifest In

denticle | ectopic | ventral (with dlp¹)

(Kirkpatrick et al., 2004)

embryonic/first instar larval cuticle (with dlp¹)

(Kirkpatrick et al., 2004)

eye photoreceptor cell & axon (with dlp¹)

(Rawson, 2005)

lamina plexus (with dlp¹)

(Rawson, 2005)

medulla (with dlp¹)

(Rawson, 2005)

presynaptic active zone | third instar larval stage (with dlp¹)

(Johnson et al., 2006)

wing margin bristle | ectopic (with dlp¹)

(Kirkpatrick et al., 2004)

Detailed Description

Statement

Reference

dlp¹/dlp² larvae have a normal number of boutons at the neuromuscular junction. Mean active zone area is significantly decreased and the number of active zones per bouton is significantly increased compared to wild type.

The amplitude of the evoked excitatory junctional potential (EJP) is increased compared to wild type at the neuromuscular junction of dlp¹/dlp² larvae. The amplitude and frequency of miniature EJPs is normal. Quantal content is increased.

(Johnson et al., 2006)

:dlp¹/dlp² mutants show axon guidance defects. At the third instar larval stage, ~30% of mutants show thickening of the lamina plexus, and >60% show crossovers between ommatidial axon bundles and abnormal photoreceptor process expansion outside the lamina plexus. At the pupal level, 80% of dlp¹/dlp² mutants have brains with irregularities in the R7 and R8 medulla termini and over 20% show medulla cartridge crossover. The differentiation of dlp¹/dlp² photoreceptors is not defective.

(Rawson, 2005)

Less than 5% of dlp² mutants survive to adulthood. dlp¹/dlp² embryos from dlp¹ germline clone females and dlp² males show a severe segment polarity defect with denticles covering the ventral surface. dlp¹/dlp² escapers show patterning defects at the anterior margin, with ectopic mechanosensory bristles on both dorsal and ventral surfaces, that are positioned further from the wing margin than bristles in wild type. This phenotype is fully penetrant, but the number of ectopic bristles varies.

(Kirkpatrick et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

dlp[+]/dlp² is a suppressor of increased cell number | female | adult stage | heat sensitive phenotype of Mmp2^Y53N/Mmp2^W307stop

(Wang and Page-McCaw, 2014)

dlp[+]/dlp² is a suppressor of increased cell number | female | adult stage | heat sensitive phenotype of Df(2R)BSC132/Mmp2^Y53N

(Wang and Page-McCaw, 2014)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

dlp¹/dlp² has eye photoreceptor cell & axon phenotype, non-suppressible by Sdc^UAS.cSa/Scer\GAL4^da.G32

(Rawson et al., 2005)

Suppressor of

Statement

Reference

dlp[+]/dlp² is a suppressor of stalk follicle cell | increased number | heat sensitive phenotype of Df(2R)BSC132/Mmp2^Y53N

(Wang and Page-McCaw, 2014)

dlp[+]/dlp² is a suppressor of stalk follicle cell | increased number | heat sensitive phenotype of Mmp2^Y53N/Mmp2^W307stop

(Wang and Page-McCaw, 2014)

Other

Statement

Reference

Notum³, dlp² has wing margin bristle | ectopic phenotype

(Kirkpatrick et al., 2004)

Notum³, dlp² has wing margin bristle | increased number phenotype

(Kirkpatrick et al., 2004)

Notum³/Notum[+], dlp² has wing margin bristle | ectopic phenotype

(Kirkpatrick et al., 2004)

Notum³/Notum[+], dlp² has wing margin bristle | increased number phenotype

(Kirkpatrick et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The increase in average cell number in the stalks between egg chambers which is seen in Mmp2^Y53N/Df(2R)BSC132 and Mmp2^Y53N/Mmp2^W307stop females after being shifted to the restrictive temperature is dominantly suppressed if the females also carry a single copy of dlp².

(Wang and Page-McCaw, 2014)

Expression of Sdc^Scer\UAS.cSa, under the control of Scer\GAL4^da.G32, fails to rescue the axon guidance defects of dlp¹/dlp² mutants.

(Rawson et al., 2005)

dlp² +/+ Notum³ transheterozygotes show increased bristle density at the anterior wing margin and ectopic bristles positioned further from the wing margin than in wild type. Neither dlp²/+ or Notum³/+ single mutant flies show this phenotype.

(Kirkpatrick et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

dlp¹

(Kirkpatrick et al., 2004)

Rescued by

dlp² is rescued by dlp^UAS.Tag:HA

(Rawson et al., 2005)

dlp² is rescued by dlp^UAS.Tag:HA/Scer\GAL4^ey.PH

(Rawson et al., 2005)

dlp¹/dlp² is rescued by dlp^UAS.cBa/Scer\GAL4^ap-md544

(Kirkpatrick et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: lethal over Df(3L)dlp^ex15.

(Kirkpatrick et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dlp²

(Wang and Page-McCaw, 2014, Wojcinski et al., 2011, Liu et al., 2010, Ren et al., 2009, Johnson et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

Open Close